A5100381412- Ion Channels and Receptors
- Connexins and lens biology
- Cancer-related gene regulation
- Mycotoxins in Agriculture and Food
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- CRISPR and Genetic Engineering
- Wheat and Barley Genetics and Pathology
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Pharmacological Receptor Mechanisms and Effects
- Fatty Acid Research and Health
- Plant-based Medicinal Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Meat and Animal Product Quality
- Renal and related cancers
- Nicotinic Acetylcholine Receptors Study
- HIV-related health complications and treatments
- Sirtuins and Resveratrol in Medicine
- Marine and coastal plant biology
- Neonatal Respiratory Health Research
Nanjing Medical University
2013-2024
Sichuan Center for Disease Control and Prevention
2024
Qingdao University
2024
Jiangsu Province Hospital
2023
University Hospital Southampton NHS Foundation Trust
2022
Beijing Meteorological Bureau
2021
Huaian First People’s Hospital
2018-2020
Xuzhou Medical College
2018-2020
Second People’s Hospital of Huai’an
2018-2020
Shanghai Ninth People's Hospital
2020
This study investigated the influence of sigma-1 receptor (σ1 R) deficiency on adult neurogenesis.We employed 8-week-old male σ1 R knockout R(-/-) ) mice to examine proliferation and differentiation progenitor cells, survival neurite growth newborn neurons in hippocampal dentate gyrus (DG).In comparison with wild-type (WT) littermates, numbers 24-h-old BrdU(+) cells Ki67(+) increased, while number 28-day-old decreased without changes proportion /NeuN(+) /GFAP(+) cells. The density was...
The aim of this research was to evaluate the potential protective mechanism astaxanthin (ASTA) against oxidative damage and inflammation caused by ochratoxin (OTA) in mouse lung. We divided mice into a control group (CG), an OTA (PG), (AG), OTA+ASTA (JG). Oxidative indices (malondialdehyde (MDA), total superoxide dismutase (T-SOD), reduced glutathione (GSH)) inflammatory markers (interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α)) were assayed lung,...
UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and pharmacodynamic effects of irinotecan patients resistant solid tumors.Patients received (75-125 mg/m(2) IV on days 1, 8, 15, 22) (50-90 day 2 25-45 23 subsequent doses) every 42 days. Blood for pharmacokinetics...
ABSTRACT Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated disease To establish an improved large animal model familial hypercholesterolemia atherosclerosis, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) was used disrupt ApoE gene Bama miniature pigs. Biallelic-modified...
A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function seipin gene mental retardation. Here, we show deficiency in hippocampal CA1 pyramidal cells the reduction peroxisome proliferator-activated receptor gamma (PPARγ). Twelve-week-old systemic knock-out mice and neuronal ( -nKO) mice, but not adipose exhibited spatial cognitive deficits as assessed Morris water maze Y-maze, which were ameliorated treatment with PPARγ agonist...
In this study, we employed 1α-hydroxylase knockout (1α-(OH)ase(-/-) ) mice to investigate the influence of 1,25-dihydroxy vitamin D(3) (1,25-(OH)(2) deficiency on adult neurogenesis in hippocampal dentate gyrus (DG). The numbers both 24-hr-old BrdU(+) cells and proliferating cell nuclear antigen positive 8-week-old 1α-(OH)ase(-/-) increased approximately twofold compared with wild-type littermates. contrast, 7- 28-day-old decreased by 50% mice, while proportion /NeuN(+) population showed no...
Noncoding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs, are involved in the development of neuropathic pain. Currently, we investigated that lncRNA X inactive-specific transcript (XIST) toll-like receptor 5 (TLR5) were greatly upregulated chronic constriction injury rat models, whereas miR-154-5p (microRNA-154-5p) was significantly downregulated. Bioinformatics analysis used to predict as a target gene XIST, dual-luciferase reporter tests proved correlation between them. We...
Abstract Background Recessive mutations in GJB2 is the most common cause of genetic hearing loss worldwide. The aim this study to determine spectrum and frequency variants Chinese Han deaf patients investigate underlying causative genes with mono-allelic mutations. Methods We analyzed mutation screening results 1852 probands apparently autosomal-recessive our laboratory. Targeted next-generation sequencing 139 known deafness-related were performed 44 Results Bi-allelic was identified 25.65%...
Summary Aim and methods Changes in cerebrospinal fluid osmotic pressure modulate brain excitability. Transient receptor potential vanilloid 4 ( TRPV 4), which is sensitive to hypotonic stimulation, expressed hippocampus. The present study investigated the effect of stimulation on hippocampal synaptic transmission role hypotonicity‐action using electrophysiological recording pharmacological technique. Results Accompanied with decrease paired pulse facilitation, field excitatory postsynaptic...
Despite extensive research on muscle loss in people living with HIV (PLWH), the prevalence and contributing factors specifically among middle-aged men remain unclear. This study aimed to determine of low mass within this demographic identify associated factors.
Dietary meats play a crucial role in human health. The objective of this survey was to determine the fatty acid content and omega-6/omega-3 polyunsaturated acids (n-6/n-3 PUFA) ratio fresh red meat (beef pork) from four cities (Shanghai, Nanjing, Yinchuan Hohhot) China. results showed that n-6/n-3 PUFA all samples ranged 6 23. total n-6 concentrations 290.54 mg/100 g beef Nanjing 1601.48 pork Hohhot, whereas n-3 46.34 96.03 Nanjing. indicated regions is unbalanced much higher than (< 5:1)...
A novel Gram-stain-negative, flagellated, rod-shaped, yellow-pigmented aerobic bacterium, strain SA925T, that is capable of degrading 1-methylphenanthrene was isolated from oil-polluted soil collected a refinery located in Guangzhou, China. Phylogenetic analysis based on the 16S rRNA gene sequence demonstrated SA925T belongs to genus Novosphingobium and evolutionarily close type strains gossypii (98.5 % similarity), panipatense (98.2 %), mathurense (98.0 %) pentaromativorans (96.5 %). The...
Voltage-gated sodium channels (VGSCs) play an important role in the control of membrane excitability. We previously reported that excitability nociceptor was increased by hypotonic stimulation. The present study tested effect hypotonicity on tetrodotoxin-sensitive current (TTX-S current) cultured trigeminal ganglion (TG) neurons. Our data show after treatment, TTX-S increased. In presence hypotonicity, voltage-dependent activation curve shifted to hyperpolarizing direction, while...
Ovarian cancer is the fourth leading cause of death in women and most fatal gynecologic malignancy. Placenta growth factor (PGF), a member vascular endothelial factor, plays an important role angiogenesis. The overexpression PGF was observed several types cancers, but clinical significance epithelial ovarian (EOC) still unknown. To explore prognostic value among patients with serous EOC, we analyzed expression 89 EOC specimens by immunohistochemistry. scoring system immunohistochemistry...
Relationship advice: Studying the structure–activity relationships of gentisides revealed that length alkyl chain, number and position hydroxy groups on benzene ring, type linker between ring chain have significant effects their neuritogenic activities. Tetradecyl 2,3-dihydroxybenzoate (ABG-001) was most promising lead compound, inducing neurite outgrowth via activation ERK signaling pathway. Detailed facts importance to specialist readers are published as "Supporting Information". Such...
Excessive presynaptic glutamate release after cerebral ischaemia leads to neuronal death mainly through excessive calcium entry of N-methyl-d-aspartate receptors (NMDARs). Our recent study reported that cerebroside can open large-conductance Ca2+-activated K+ (BKCa) channels. The present evaluated the effects cerebroside-A (CS-A), a single molecule isolated from an edible mushroom, on brain injury focal or global in adult male mice and rats. We herein report treatment with CS-A 60-min middle...
Tetradecyl 2,3-dihydroxybenzoate, termed ABG001, has been reported to enhance neurite outgrowth of PC12 cells. Herein, we report that oral administration ABG001 for five days adult male mice could dose-dependently survival and growth newborn cells in hippocampal dentate gyrus (DG) without changes cell proliferation differentiation progenitor The (0.5 mg/kg) enhanced the phosphorylation tyrosine kinase A (TrkA) receptor, which induced increases levels ERK, Akt mTOR hippocampus....
SAV1 is a human homolog of salvador that contains two protein-protein interaction modules known as WW domains and acts scaffolding protein for Hpo Warts. to be tumor suppressor, but its clinical prognostic implications remain elusive. This study aimed at evaluating the significance associated expression in pancreatic ductal adenocarcinoma (PDAC) patients. The tissue specimens PDAC patients were assayed with immunohistochemistry on microarray. correlations between clinicopathological...