A5062084535- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Curcumin's Biomedical Applications
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Nutritional Studies and Diet
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Garlic and Onion Studies
- Cancer-related Molecular Pathways
- Vitamin C and Antioxidants Research
- Wnt/β-catenin signaling in development and cancer
- Breastfeeding Practices and Influences
- Aluminum toxicity and tolerance in plants and animals
- FOXO transcription factor regulation
- HIV-related health complications and treatments
- Nuclear Receptors and Signaling
- Phytoestrogen effects and research
- Human Health and Disease
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
Nanjing Medical University
2016-2025
National University Health System
2020
Breast cancer is the most common in women. Bisphenol A (BPA), as a known endocrine disrupter, closely related to development of breast cancer. Curcumin has been clinically used chemopreventation and treatment cancer; however, it remains unknown whether microRNAs are involved curcumin‐mediated protection from BPA‐associated promotive effects on In present study, we showed that BPA exhibited estrogenic activity by increasing proliferation estrogen‐receptor‐positive MCF‐7 human cells triggering...
Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus, targeting CSCs may be a promising strategy for cancer therapy. Wnt/β-catenin and Sonic Hedgehog pathways play an important regulatory role maintaining CSC characteristics. Natural compounds, such as curcumin, possess chemopreventive properties. However, interventional effect curcumin on lung has not been clarified. In present study, tumorsphere formation assay was used to enrich from A549 H1299 cells....
The beneficial effects of tea consumption on cancer prevention have been generally reported, while (-)-Epigallocatechin-3-gallate (EGCG) is the major active component from green tea. Cancer stem cells (CSCs) play a crucial role in process development. Targeting CSCs may be an effective way for intervention. However, EGCG colorectal and underlying mechanisms remain unclear. Spheroid formation assay was used to enrich cell lines. Immunoblotting analysis quantitative real-time polymerase chain...
Cancer stem cells (CSCs) play an essential role in the progression of many tumors. Sonic hedgehog (Shh) and Wnt/β-catenin pathways are crucial maintaining stemness CSCs. Curcumin has been shown to possess anticancer activity. However, interventional effect curcumin on breast CSCs not elucidated. In present study, we investigated Shh pathway inhibition We showed that levels markers were significantly elevated SUM159 MCF7 sphere-forming cells. further illustrated effectively decreased activity...
Abstract Curcumin is a phytochemical which exhibits significant inhibitory effect in multiple cancers including prostate cancer. MicroRNA‐34a (miR‐34a) was found to be master tumor suppressor miRNA and regulated the growth of cancer cells. To date, however, role miR‐34a anticancer action curcumin against has been rarely reported. In present study, we showed that altered expression cell cycle‐related genes (cyclin D1, PCNA, p21) inhibited proliferation Furthermore, significantly upregulated...
Abstract Cancer stem cells (CSCs) play a central role in the development of breast cancer. The canonical Wnt/β‐catenin signal pathway is critical for maintaining CSCs characteristics. Diallyl trisulfide (DATS), natural organosulfur compound from garlic, exhibits effective antitumor properties. However, DATS regulating activity and underlying molecular mechanisms remain obscure. In present study, we reported that efficiently inhibited viability as evidenced by reducing turmorspheres...
Abstract The aim of the present study was to investigate role endoplasmic reticulum (ER) stress in bisphenol A (BPA) – induced hepatic lipid accumulation as well protective effects Sulforaphane (SFN) this process. Human hepatocyte cell line (LO2) and C57/BL6J mice were used examine BPA-triggered underlying mechanism. Hepatic accumulation, triglycerides (TGs) levels, expression levels lipogenesis-related genes proteins ER pathway measured. It revealed that BPA treatment increased number...
The omnipresence of human phthalate (PAE) exposure is linked to various adverse health issues, including breast cancer. However, the effects low-dose PAE on cancer stem cells (BCSCs) and underlying mechanism remain unexplored.BCSCs from cell lines (MDA-MB-231 MCF-7) were enriched using a tumorsphere formation assay. Gene protein expression was detected by measurement quantitative real-time reverse transcription PCR, western blot, immunofluorescence assays. Transient transfection assays used...
Polyamines in human milk are essential for the rapid growth and development of neonates infants. However, concentrations polyamines have not been well characterized special methods detecting milk, formula or other dairy products remain largely unavailable to date. In this study, an accurate sensitive method based on trifluoroacetic acid anhydride (TFAA) derivatization, double solid-phase extraction (SPE) purification, gas chromatography-triple quadrupole mass spectrometry (GC-QqQ MS) was...
Background: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, underlying molecular mechanisms remain unclear.The induction cancer stem cells (CSCs) by TS represents an early event in tumor initiation.The cancer-related gene ΔNp63α is highly expressed epithelial tissues and drives formation cell properties.This study investigated role long-term acquisition TS-induced CSC-like properties. Methods:The expression levels ΔNp63α, CSC markers, interleukin (IL)-6...
Ambient fine particulate matter (PM2.5) is capable of inducing pulmonary oxidative injury. Autophagy maintains basal cellular homeostasis and plays a critical role in the pathogenesis lung diseases. Resveratrol, natural polyphenol, an effective antioxidant agent against (PM)-induced injuries. The current study was designed to investigate whether resveratrol can regulate autophagy process PM2.5-mediated In mice model PM2.5 exposure, we found that increased contents malondialdehyde (MDA)...