Stefanie Castell
A5048320425- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Team Dynamics and Performance
- SARS-CoV-2 and COVID-19 Research
- Health and Medical Studies
- Vector-borne infectious diseases
- Conferences and Exhibitions Management
- Vaccine Coverage and Hesitancy
- Health disparities and outcomes
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Migration, Health and Trauma
- Diagnosis and treatment of tuberculosis
- Data-Driven Disease Surveillance
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Mosquito-borne diseases and control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacterial Identification and Susceptibility Testing
- Zoonotic diseases and public health
- Mobile Health and mHealth Applications
Helmholtz Centre for Infection Research
2015-2025
German Center for Infection Research
2015-2024
Medizinische Hochschule Hannover
2012-2023
Center for Experimental and Clinical Infection Research
2017-2023
Ludwig-Maximilians-Universität München
2021
German Central Institute for Social Issues
2010-2016
Gemeinsamer Bundesausschuss
2012
Humboldt-Universität zu Berlin
2000-2002
Charité - Universitätsmedizin Berlin
2000-2002
Reliability of measurements is a prerequisite medical research. For nominal data, Fleiss' kappa (in the following labelled as K) and Krippendorff's alpha provide highest flexibility available reliability measures with respect to number raters categories. Our aim was investigate which confidence intervals best statistical properties for assessment inter-rater in different situations.We performed large simulation study precision estimates K determine empirical coverage probability...
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection prevention disease. Specifically, NAKO designed novel better characterize established protection for development cardiovascular cancer, diabetes, neurodegenerative psychiatric musculoskeletal respiratory infectious diseases in random sample general population. Between 2014 2019, total...
We applied serial analysis of gene expression (SAGE) to study differentially expressed genes in mouse brain 14 hr after the induction focal cerebral ischemia. Analysis >60,000 transcripts revealed 83 upregulated and 94 downregulated (more than or equal eightfold). Reproducibility was demonstrated by performing SAGE duplicate on same starting material. Metallothionein-II (MT-II) most significantly transcript ischemic hemisphere. MT-I MT-II are assumed be induced metals, glucocorticoids,...
The aim of this study was to identify the occupational risk for a SARS-CoV-2 infection in nationwide sample German workers during first wave COVID-19 pandemic (1 February-31 August 2020).We used data 108 960 who participated COVID follow-up survey National Cohort (NAKO). Occupational characteristics were derived from Classification Occupations 2010 (Klassifikation der Berufe 2010). PCR-confirmed infections assessed self-reports. Incidence rates (IR) and incidence rate ratios (IRR) estimated...
Seit der Veröffentlichung Empfehlungen des DZK zur medikamentösen Therapie Tuberkulose (TB) 2001 sowie Chemoprävention latenten tuberkulösen Infektion (LTBI) 2004 sind verschiedene neue internationale erschienen. Diese in die jetzigen Empfehlungen, welche sowohl aktiven als auch präventive Behandlung darstellen, integriert, wobei Deutschland-spezifische Adaptationen betont werden. Jeweils gesondert wird das aktuelle Vorgehen bei Mono-, Poly- und Multiresistenzen oder...
Corrected by: Neue Empfehlungen für die Umgebungsuntersuchungen bei TuberkulosePneumologie 2011; 65(06): e50-e50DOI: 10.1055/s-0030-1256509
4,444 new cases of tuberculosis (TB) were reported in Germany 2009; those, the proportion multidrug-resistant (MDR)-TB increased to 2.1% (63 cases). On basis therapy guidelines German Central Committee against Tuberculosis and World Health Organization guidelines, this study estimates mean direct outpatient combined in- costs TB, together with other attributable disease on most recent official health statistics scientific literature. According this, (rounded) per case €1,197 (adults) €1,006...
Studies measuring contact networks have helped to improve our understanding of infectious disease transmission. However, several methodological issues are still unresolved, such as which method measurement is the most valid. Further, complete network analysis requires data from most, ideally all, members a and, achieve this, acceptance method. We aimed at investigating error by comparing two methods – paper diaries vs. wearable proximity sensors that were applied concurrently same...
The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides overview of design, methods, participation in the examinations, quality assurance based on midterm baseline dataset (MBD) recruitment.More than 200,000 women men aged 20-69 years derived from random samples general population were recruited 18 centers (2014-2019). data collection comprised physical...
Abstract SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number amino acid alterations in Spike protein date. Thus, they may efficiently recognition by neutralizing antibodies, allowing breakthrough infections convalescent vaccinated individuals particular those who only received primary immunization scheme. We analyzed...
Abstract Background The COVID-19 pandemic restrictions posed challenges to maintaining healthy lifestyles and physical well-being. During the first mobility from March mid-July 2020, German population was advised stay home, except for work, exercise, essential shopping. Our objective comprehensively assess impact of these on changes in activity sedentary behavior identify most affected groups. Methods Between April 30, May 12, we distributed a COVID-19-specific questionnaire participants...
Ebola virus disease (EVD) outbreaks have occurred during the past 5 decades, but none has affected European countries like 2014 epidemic in West Africa. We used an online questionnaire to investigate risk perceptions Germany this peak. Our covered perceptions, knowledge about transmission routes, media use, reactions outbreak, attitudes toward measures prevent spread of EVD and vaccination against EVD, willingness volunteer for aid missions. Of 974 participants, 29% indicated that they...
Increasing availability of the Internet allows using only online data collection for more epidemiological studies. We compare response patterns in a population-based health survey two designs: mixed-mode (choice between paper-and-pencil and questionnaires) online-only design (without choice).We used from longitudinal panel, Hygiene Behaviour Infectious Diseases Study (HaBIDS), conducted 2014/2015 four regions Lower Saxony, Germany. Individuals were recruited address-based probability...
Knowing about predictors of attrition in a panel is important to initiate early measures against loss participants. We investigated both and late phase an online with special focus on preferences regarding mode participation.We used data from the HaBIDS that was designed investigate knowledge, attitudes, practice infections German general population. divided into two phases: initial when some participants could choose their preferred participation (paper-and-pencil or online) extended were...
Objectives The present study introduces the assessment of depression and depressive symptoms in German National Cohort (NAKO), a population-based mega cohort. Distribution core measures, associations with sociodemographic factors are examined.Methods current analysis includes data from first 101,667 participants (NAKO freeze 100,000). Depression were assessed using modified version section Mini-International Neuropsychiatric Interview (MINI), self-reported physician's diagnosis depression,...
Objectives Childhood maltreatment affects 20–30% of the German population and is an important risk factor for physical mental diseases in adult life. This study reports first results distribution childhood population-based mega cohort National Cohort (NAKO) estimates associations with affective symptoms adulthood.Methods The Trauma Screener (CTS), a short version Questionnaire, was used 83,995 adults (age: 20–72 years; 47.3% men) NAKO. five-item CTS assesses severity three types abuse two...
Abstract Background The European Working Group on Sarcopenia in Older People (EWGSOP) updated 2018 the cut-off points for low grip strength to assess sarcopenia based pooled data from 12 British studies. Objective Comparison of EWGSOP2 those derived a large German sample. Methods We assessed distribution across age and men women (peak mean -2.5 × SD) 200,389 National Cohort (NAKO) participants aged 19–75 years. In 1,012 Cooperative Health Research Region Augsburg (KORA)-Age 65–93 years, we...
In den letzten Jahren hat sich die epidemiologische Situation der Tuberkulose (TB) in Deutschland deutlich verbessert. Dennoch ist das Risiko für eine Tuberkuloseinfektion weiterhin Personen erhöht, häufig und/oder über längere Zeit intensiv ungeschützten Kontakt mit ansteckungsfähigen Tuberkulosekranken haben. Für Infektionsprävention von besonderer Bedeutung sind schnelle Diagnose, frühe Einleitung einer effektiven Therapie und adäquate Hygienemaßnahmen. Die vorliegenden Empfehlungen...
Early during the pandemic and following protective countermeasures, an interest in consequences of enacted restriction social contacts for mental health population arose. Loneliness describes perceived quality one's own relationships with other individuals. Several prior studies reported associations loneliness different somatic psychiatric disorders.To analyse frequency its association depression anxiety symptoms first wave Germany May 2020.The German National Cohort (NAKO) had recruited...
Childhood trauma is associated with somatic and mental illness in adulthood. The strength of the association varies as a function age, sex, type trauma. Pertinent studies to date have mainly focused on individual diseases. In this study, we investigate between childhood multiplicity illnesses
Background Using data from the largest German cohort study, we aimed to investigate sex differences in relationship of socioeconomic position (SEP) with cardiovascular disease (CVD), CVD risk factors, and estimated risk. Methods Results A total 204 780 (50.5% women) participants baseline examination population‐based NAKO (German National Cohort) were included. Logistic, multinomial, linear regression models used estimate sex‐specific odds ratios (ORs) β coefficients 95% CIs CVD, very...
Abstract Background The educational gradient in depressive symptoms is well documented. Gender and history of migration have also been found to be associated with symptoms. Intersectional approaches enable the analysis interplay different social factors at a time gain deeper understanding inequalities In this study, intersectional according education, gender are analysed. Methods German National Cohort (NAKO, N = 204,783) collected information on (PHQ-9), which was used as an outcome...
Abstract The German National Cohort (NAKO) is the largest population-based epidemiologic cohort study in Germany and investigates causes of most common chronic diseases. Between 2014 2019, a total 1.3 million residents aged 20–69 years from 16 regions were randomly selected general population invited to participate following highly standardized recruitment protocol. overall response was 15.6% differed considerably across centers (7.6–30.7%). Females more likely than males (17.5% vs. 14.1%)...
Die nichttuberkulösen Mykobakteriosen umfassen eine Gruppe von Erkrankungen, die Mykobakterien verursacht werden, nicht dem <i>Mycobacterium (M</i>.)<i> tuberculosis-</i>Komplex und <i>M. leprae</i> zugerechnet werden durch breite Vielfalt in Hinsicht auf ihr Vorkommen ihre Anpassungen an spezifische Umweltbedingungen charakterisiert sind. Einige Spezies können definierte Krankheitsbilder insbesondere bei Patienten mit systemischer Immunsuppression, vorbestehenden Lungenerkrankungen oder...