A5065529064- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Transgenic Plants and Applications
- SARS-CoV-2 detection and testing
Helmholtz Centre for Infection Research
2022-2025
Centre for Individualised Infection Medicine
2024
Medizinische Hochschule Hannover
2024
The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, inhibitors being developed therapy. However, Omicron variant, which currently dominates pandemic, prefers endo/lysosomal cysteine cathepsin L over cell entry, raising doubts as to whether would be suitable treatment of patients infected with variant. Nevertheless, contribution spread in host is largely...
Abstract SARS-CoV-2 variants accumulating immune escape mutations provide a significant risk to vaccine-induced protection against infection. The novel variant of concern (VoC) Omicron BA.1 and its sub-lineages have the largest number amino acid alterations in Spike protein date. Thus, they may efficiently recognition by neutralizing antibodies, allowing breakthrough infections convalescent vaccinated individuals particular those who only received primary immunization scheme. We analyzed...
ABSTRACT The recently detected Omicron BA.2.86 lineage contains more than 30 amino acid mutations relative to BA.2. and its JN.1 derivative evade neutralization by serum antibodies of fully vaccinated individuals. In this study, we elucidate epitopes driving the immune escape via pseudovirus neutralization. Thus, have generated 33 mutants, each reverting a single mutation back We use library in an approach that call reverse mutational scanning define distinct titers against epitope....
The recently detected Omicron BA.2.86 lineage contains more than 30 amino acid mutations relative to BA.2. and its JN.1 derivative evade neutralization by serum antibodies of fully vaccinated individuals. In this study, we elucidate epitopes driving the immune escape via pseudovirus neutralization. Here generate 33 mutants, each reverting a single mutation back We use library in an approach that call reverse mutational scanning define distinct titers against epitope. Mutations within...
Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, would provide lasting protection needed, still unavailable. Cytomegaloviruses (CMVs) and uniquely responses. Used as vectors, they may be attractive tools obviate need for boosters. Therefore, we tested murine CMV (MCMV) vector in relevant preclinical models of immunization challenge. We previously...
Abstract The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells inhibitors being developed therapy. However, Omicron variant, which currently dominates pandemic, prefers endo/lysosomal cysteine cathepsin L over cell entry, raising doubts whether would be suitable treatment of patients infected with variant. Nevertheless, contribution to spread in host is largely...
Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have led to vaccine fatigue. Hence, would provide lasting protection needed, still unavailable. Cytomegaloviruses (CMV) and uniquely responses. Used as vectors, they may be attractive tools obviate need for boosters. Therefore, we tested murine CMV (MCMV) vector in relevant preclinical models of immunization challenge. We previously developed...