A5022356274- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- CAR-T cell therapy research
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Hematological disorders and diagnostics
- Sleep and related disorders
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
- Soft tissue tumor case studies
- Parvovirus B19 Infection Studies
- Infant Health and Development
- Peptidase Inhibition and Analysis
- Renal and related cancers
- Cytomegalovirus and herpesvirus research
- Inflammatory Biomarkers in Disease Prognosis
- Management of metastatic bone disease
- Testicular diseases and treatments
- Cancer Mechanisms and Therapy
Ludwig-Maximilians-Universität München
2022-2025
LMU Klinikum
2022-2025
Background: The prognosis of patients with advanced soft tissue sarcoma (STS) remains dismal. Trofosfamide (TRO) has been proposed as a well-tolerated oral maintenance therapy. This retrospective analysis aims to determine the value this Methods: Fifty-nine STS who received TRO therapy between 2016 and 2022 were reviewed analysed regarding clinical parameters outcomes. Results: median age was 48 years; most common histological subtype synovial (n = 22, 37%), 71% 42) presented metastatic...
Abstract Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course disease. Suspicious lymph nodes (LN) staging imaging are a frequent topic discussion multidisciplinary tumor boards. Predictive markers needed to facilitate stratification improve treatment STS patients. In this study, 56 with radiologically suspicious subsequently histologically examined LN were reviewed. Patients benign (n = 26) metastatic 30) analyzed regard...
Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards lacking. This study aimed to assess the impact of LAT on survival STS and identify prognostic factors.
ABSTRACT Background Dacarbazine is currently considered the better combination partner for doxorubicin compared to ifosfamide treatment of leiomyosarcoma (LMS). Regional hyperthermia (RHT) combined with neoadjuvant chemotherapy has been shown improve survival in patients locally advanced high‐risk STS. We sought evaluate role and dacarbazine (AD) versus (AI) RHT LMS. Methods Patients high‐grade LMS, including limited metastases, eligible first‐line either AI + or AD between 2014 2022 were...
Abstract Background The current understanding of the prognostic value routine pre-treatment laboratory parameters in patients with high-risk soft tissue sarcoma (HR-STS) is limited. We sought to analyze several inflammatory biomarkers a large cohort HR-STS undergoing neoadjuvant therapy followed by curative surgical resection. Methods 123 locally advanced undifferentiated pleomorphic (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), and synovial (SS) who underwent preoperative chemotherapy...
Abstract Background The prognostic and predictive value of obesity sarcopenia remains poorly defined in patients with high-risk soft tissue sarcoma (HR-STS). We sought to correlate clinical outcomes CT-based body composition parameters HR-STS undergoing a multimodal preoperative therapy. impact radiologic histopathologic response treatment was correlated individual fat muscle distribution. Methods Patients locally advanced non-abdominal chemotherapy + regional hyperthermia (RHT) +/-...
Abstract We report a long-lasting response to the immune checkpoint inhibitor nivolumab in combination with regional hyperthermia (RHT) patient recurrent metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) negative programmed death ligand 1 (PD-L1) expression. Treatment was well tolerated no local side effects. Tumor-related symptoms orbital masticator area gradually decreased under treatment RHT. Over course of treatment, magnetic resonance imaging (MRI) showed tumor control heated...
Abstract Purpose Diarrhea is an important cause of morbidity and mortality in immunocompromised patients. After including sapovirus to the viral gastroenteritis screening our institution’s laboratory, we noticed increase infections among kidney transplant recipients. Therefore, assumed former gastrointestinal tract with unidentified pathogens could have been caused by sapovirus. To better understand characteristics a infection high-risk group initiated this study. Methods Over period 6...
Due to poor outcomes and limited treatment options, patients with advanced bone soft tissue sarcomas (BS/STS) may undergo comprehensive molecular profiling of tumor samples identify possible therapeutic targets. The aim this study was determine the impact routine in setting a dedicated precision oncology program BS/STS German large-volume sarcoma center.92 who received genomic (CGP) were subsequently discussed our board (MTB) between 2016 2022 included. Patient records retrospectively...
(1) Background: The expression of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), an immune checkpoint receptor on cells, has been associated with dismal outcomes advanced tumor stages in various solid tumors. blockade TIM-3 is currently under examination several clinical trials. This study examines high-risk soft tissue sarcomas (HR-STS). (2) Methods: Tumor level was analyzed pre-treatment biopsies patients HR-STS. correlated clinicopathological parameters including...
Alveolar soft part sarcoma (ASPS) is a rare malignancy with low sensitivity to chemotherapy. While localized ASPS has very good prognosis after resection, the 5-year overall survival rate drops substantially in metastatic disease. We report case of an 80-year-old male patient left elbow and metastasis lung, lymph nodes peritoneum. After weighing benefits risks, systemic treatment anti-PD-1 checkpoint inhibitor pembrolizumab combined vascular endothelial growth factor receptor tyrosinkinase...
Abstract Purpose After including sapovirus to the viral GI-screening routine of our institution's laboratory, we noticed an increasing number diagnosis among kidney transplant recipients. Therefore, assumed former GI-tract infections with unidentified pathogens could have been caused by as well. In order better understand characteristics a infection in high-risk group initiated this study. Methods 13 renal recipients symptoms and later identified viral/unknown were included. Four patients...
Was ist neu? Lokalisierte Stadien Die kurative Resektion +/– prä- oder postoperative Strahlentherapie die Therapiebasis im lokalisierten Stadium. Bei hohem Rezidivrisiko eine neoadjuvante anthrazyklinbasierte Kombinationstherapie, ggf. in Kombination mit regionaler Hyperthermie, zu erwägen. Metastasiertes Stadium Anthrazykline gelten auch metastasierten weiterhin als Standard für Erstlinientherapie. Anthrazyklinbasierte Kombinationen können je nach Subtyp und Remissionsdruck Betracht gezogen...
Abstract Introduction: Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course disease. Suspicious lymph nodes staging imaging are a frequent matter discussion multidisciplinary tumor boards. Predictive markers needed to enable stratification improve treatment STS patients. Materials Methods In this study, 56 with radiologically suspicious subsequently histologically examined (LN) were reviewed. Patients benign (n = 26)...
Zusammenfassung Die medizinische Verwendung von Cannabis hat in den letzten Jahren Europa und Nordamerika an Popularität gewonnen. Cannabinoide sind sowohl als Fertigarzneimittel auch Blüten- Extraktform verfügbar. Der vorliegende Artikel legt Fokus auf die supportive Therapie onkologischer Patienten. Mögliche Indikationen Schmerzen, Chemotherapie-bedingte Übelkeit Erbrechen, Appetitlosigkeit Geschmacksveränderungen. Trotz des enormen Hypes um Medizin ist Evidenz für dessen Anwendung bei...
Zusammenfassung Die medizinische Verwendung von Cannabis hat in den letzten Jahren Europa und Nordamerika an Popularität gewonnen. Cannabinoide sind sowohl als Fertigarzneimittel auch Blüten- Extraktform verfügbar. Der vorliegende Artikel legt Fokus auf die supportive Therapie onkologischer Patienten. Mögliche Indikationen Schmerzen, Chemotherapie-bedingte Übelkeit Erbrechen, Appetitlosigkeit Geschmacksveränderungen. Trotz des enormen Hypes um Medizin ist Evidenz für dessen Anwendung bei...
Zusammenfassung Die medizinische Verwendung von Cannabis hat in den letzten Jahren Europa und Nordamerika an Popularität gewonnen. Cannabinoide sind sowohl als Fertigarzneimittel auch Blüten- Extraktform verfügbar. Der vorliegende Artikel legt Fokus auf die supportive Therapie onkologischer Patienten. Mögliche Indikationen Schmerzen, Chemotherapie-bedingte Übelkeit Erbrechen, Appetitlosigkeit Geschmacksveränderungen. Trotz des enormen Hypes um Medizin ist Evidenz für dessen Anwendung bei...