A5086136709- Palliative Care and End-of-Life Issues
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Medical and Health Sciences Research
- Epilepsy research and treatment
- Pain Management and Opioid Use
- Healthcare Decision-Making and Restraints
- Intensive Care Unit Cognitive Disorders
- Pharmaceutical Practices and Patient Outcomes
- Health and Medical Studies
- Biomedical and Chemical Research
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Placebo Effect
- Complementary and Alternative Medicine Studies
- Pharmacovigilance and Adverse Drug Reactions
- Family and Patient Care in Intensive Care Units
- Pain Mechanisms and Treatments
- Clinical practice guidelines implementation
- Medical Practices and Rehabilitation
- Psychosomatic Disorders and Their Treatments
- Anesthesia and Sedative Agents
- Childhood Cancer Survivors' Quality of Life
- Medication Adherence and Compliance
- Pediatric Pain Management Techniques
- German Literature and Culture Studies
LMU Klinikum
2016-2025
Ludwig-Maximilians-Universität München
2016-2025
München Klinik
2016-2024
Bayer (Germany)
2020
University Hospital Bonn
2016
Hospices Civils de Lyon
2000
Background Nausea and vomiting significantly impact the quality of life in palliative care. Due to various underlying causes, treatment approaches vary. However, scientific evidence on pharmacotherapeutic management is limited, complicating decisions. Objective assess current antiemetic approach care Germany. Methods A retrospective observational study (15 months) was conducted, evaluating clinical records adult patients admitted a German hospital. Symptom burden (Integrated Palliative...
Background: Off-label use of drugs is an integral part everyday clinical practice in palliative medicine. However, it associated with many uncertainties, that is, drug therapy safety or legal issues including cost coverage. Healthcare professionals often lack time and resources for comprehensive literature search patient-specific risk-benefit analyses. Aim: The aim this project to develop, evaluate rate agreement/disagreement on treatment recommendations off-label adult Design: Online Delphi...
The COVID-19 pandemic impacts on working routines and workload of palliative care (PC) teams but information is lacking how resource use associated hospital costs for PC changed at patient-level during the pandemic. We aim to describe differences in patient characteristics, processes specialist (PC unit advisory team) a university before first year.
Abstract Background Intranasal (i.n.) drug application is a widely known and low-invasive route of administration that may be able to achieve rapid symptom control in terminally ill patients. According the German S3 guideline “Palliative care for patients with incurable cancer”, benzodiazepines, such as midazolam, are recommended treatment terminal agitation. To best our knowledge there no evidence i.n. midazolam We aim assess use an alternative subcutaneous drug. Methods In this...
Background: Off-label-use is an indispensable element of palliative medicine. Up to one third all drugs are prescribed beyond their licence. It challenging find the right balance between potential risks and benefits in context limited therapeutic options. To date, little known how physicians deal with this challenge daily practice.Objectives: evaluate (1) awareness German medicine off-label-use, (2) basis for decision-making (3) existence guidelines off-label prescribing (4) practical...
ObjectivesThere is scarce information about sedation in nursing homes at the end of life. We aimed to assess (1) use sedatives generally and "sedatives with continuous effect," based on objective operational criteria, within last week life (2) factors associated this treatment.DesignRetrospective cohort study, using homes' medical records.Setting ParticipantsResidents who died 4 German from January 2015 December 2017 whose records were available (n = 512).MethodsSedatives analyzed those...
Off-label drug use is common practice in palliative care. It may pose a risk to the patient and benefit should outweigh harm. A decision documentation aid for off-label was developed support practitioners clinical use. Using example of rectal administration levetiracetam three cases, utilisation benefits are presented discussed. The clearly an experimental treatment approach with little underlying evidence. To document decision-making process or against such practice, it helpful have...
Pharmacotherapy is essential in palliative medicine. Besides potential benefits, pharmacotherapy also poses risks that need to be minimized for patient safety. Pharmacists can play an important role identifying, solving, and avoiding drug-related problems (DRPs). The aim of this study was evaluate pharmaceutical interventions on safety drug therapy patients inpatient care unit. All admitted a unit over 12-month period were screened eligibility (ie, life expectancy >4 weeks). To identify...
<h3>Objective</h3> Off-label drug use seems to be integral adult palliative care pharmacotherapy. Balancing potential risks and benefits in the context of limited therapeutic options is challenging. To provide specific support for clinicians dealing with off-label use, it essential understand everyday clinical practice. The aim this pilot study was quantify describe an unit. <h3>Methods</h3> Retrospective chart review all patients treated on a unit October 2017. All data (eg, indication,...
Pharmacotherapy plays a crucial role in symptom management palliative care and is associated with risks potentially leading to drug-related problems (DRP). Pharmacists can identify DRPs advise prescribers on optimizing drug therapy. The aim of this study was DRP unit (PCU) evaluate corresponding pharmaceutical interventions. A non-randomized before-and-after PCU starts control phase, an interphase, intervention phase. Primary endpoint: DRP, including interventions their acceptance....
Sedatives are frequently used at the end of life in specialist palliative care. There is scarce information about their use nursing homes. Therefore, we aimed to assess (1) sedatives generally and (2) 'sedatives with continuous effect', based on objective operational criteria, within last week a home. This was retrospective cohort study residents who died German home between 1/2015 12/2017, using home's medical records, which contained drug sheets nurses' notes. analysed were those...