A5075628861- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Renal function and acid-base balance
- Antibiotics Pharmacokinetics and Efficacy
- Family and Patient Care in Intensive Care Units
- Atrial Fibrillation Management and Outcomes
- Cancer survivorship and care
- Ultrasound in Clinical Applications
- Anesthesia and Pain Management
- Respiratory Support and Mechanisms
- Vascular Procedures and Complications
- Nosocomial Infections in ICU
- Blood Pressure and Hypertension Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrhythmias and Treatments
- Sulfur Compounds in Biology
University of Brescia
2023-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2023
Azienda Ospedaliero-Universitaria Careggi
2011-2022
University of Florence
2011-2021
Endothelial cells line the inner portion of heart, blood vessels, and lymphatic vessels; a basal membrane extracellular matrix lines extraluminal side endothelial cells. The apical is site for glycocalyx, which complex network macromolecules, including cell-bound proteoglycans sialoproteins. Sepsis-associated alterations this structure may compromise permeability with associated interstitial fluid shift generalized edema. Indeed, in sepsis, glycocalyx acts as target inflammatory mediators...
Postoperative atrial fibrillation (POAF) is common among surgical patients and associated with a worse outcome. Pathophysiology of POAF not fully disclosed, several perioperative factors could be involved. Direct cardiac stimulation from use catecholamines or increased sympathetic outflow volume loss/anaemia/pain may play role. Metabolic alterations, such as hypo-/hyperglycaemia electrolyte disturbances, also contribute to POAF. Moreover, inflammation, both systemic local, role in its...
Sedation is standard practice in the ICU [1]. The aim of this study was to investigate efficiency and safety MIRUS™ system (Pall Medical), a new device for sedation patients [2]. delivers volatile anesthetics mechanically ventilated patients. An open reservoir scavenger dedicated gas filter avoid residual anesthetic halogenate escaping into room air.
Background Continuous veno-venous hemodialysis with high cut-off membranes (HCO-CVVHD) removes inflammatory mediators involved in organ dysfunction during sepsis. The aim of the present study was to assess variations SOFA score and identify early predictors short-term mortality a cohort patients septic shock, treated HCO-CVVHD for acute kidney injury (AKI). Methods An observational prospective multicenter conducted four mixed medical-surgical ICUs. Thirty-eight shock AKI (KDIGO stage≥1) have...
Gram-negative bacteria are increasingly responsible for nosocomial infections, including ICU-acquired infections. Due to high virulence, rate of multi-drug resistance and limited availability new agents, these infections create cumbersome clinical burdens, making it important reduce the risk their occurrence. The aim study was assess epidemiology-related factors outcomes Gram-negative, in a cohort medical-surgical patients. A retrospective survey conducted on all patients admitted mixed ICU...
To evaluate the feasibility and safety of MIRUS system (Pall International, Sarl, Fribourg, Switzerland) for sedation with sevoflurane postsurgical ICU patients to atmospheric pollution during sedation.Prospective interventional study.Surgical ICU. February 2016 December 2016.Postsurgical requiring admission, mechanical ventilation, sedation.Sevoflurane was administered targeted a Richmond Agitation Sedation Scale from -3 -5 by adaptation minimum alveolar concentration.Data collected...
Abstract Palliative care, with its focus on comprehensive patient assessment encompassing physical, social, emotional, and spiritual pain, plays a crucial role in modern medicine. Despite significance, integration oncology other healthcare specialties often occurs late the disease trajectory. Strategies to bridge this gap include considering “rebranding” of palliative care “supportive care.” Early initiation although challenging define precisely, aims improve quality life for patients their...
The cardiorenal syndrome is a clinical and pathophysiological entity defined as the concomitant presence of renal cardiovascular dysfunction. In patients with severe sepsis septic shock, acute cardiovascular, derangements are common, that is, syndrome. aim this paper to describe pathophysiology features in light actual experimental evidence. particular, importance systemic intrarenal endothelial dysfunction, alterations kidney perfusion, myocardial function, organ “crosstalk” ubiquitous...
Worldwide, the widespread use of extracorporeal blood purification therapies (EBPTs) is progressively increasing in everyday clinical practice, particularly critical care settings. The efficacy EBPTs on removal inflammatory mediators already well established literature. Nonetheless, research cumbersome this setting, and many trials aiming at exploring effect outcomes have failed demonstrating consistent results regarding 28-day- or hospital-mortality rates. In recent years, data emerging...
Abstract An accurate assessment of preoperative risk may improve use hospital resources and reduce morbidity mortality in high-risk surgical patients. This study aims at implementing an automated calculator based on Artificial Neural Network technology to identify patients for postoperative complications. We developed the new SUMPOT factors previously used other scoring systems tested it a cohort 560 undergoing elective or emergency procedures subsequently admitted intensive care units,...