A5009043645- Pleural and Pulmonary Diseases
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Lung Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Abdominal Surgery and Complications
- Pneumothorax, Barotrauma, Emphysema
- Hernia repair and management
- Vascular Tumors and Angiosarcomas
- Pelvic and Acetabular Injuries
- Pancreatic and Hepatic Oncology Research
- Trauma and Emergency Care Studies
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Appendicitis Diagnosis and Management
- Biomedical and Chemical Research
- Ultrasound in Clinical Applications
- Patient Safety and Medication Errors
- Intraperitoneal and Appendiceal Malignancies
- Surgical site infection prevention
- Gastrointestinal Tumor Research and Treatment
- Abdominal Trauma and Injuries
- Palliative Care and End-of-Life Issues
Heinrich Heine University Düsseldorf
2014-2025
Düsseldorf University Hospital
2014-2025
Alexandria University
2025
Surgical site infections frequently occur after open abdominal surgery. Intraoperative wound irrigation as a preventive measure is common practice worldwide, although evidence supporting this lacking.
Abstract Background Circulating tumour cells (CTCs) and tumour-derived extracellular vesicles (tdEVs) have great potential for monitoring therapy response early detection of relapse, facilitating personalized adjuvant therapeutic strategies. However, their low abundance in peripheral blood limits informative value. In this study, we explored the presence CTCs tdEVs collected intraoperatively from a tumour-draining vein (DV) via central venous catheter (CVC) prior to resection. Methods...
Background: Coronavirus disease 19 (COVID-19) substantially affects cancer patients due to adverse outcomes and disruptions in care. Recent studies have indicated the additional stress anxiety burden arising from pandemic impairing quality of life this vulnerable group patients. However, with represent a heterogenous group. Therefore, we conducted study on pancreatic cancer, requiring demanding surgical interventions chemotherapy regimens its aggressive tumor biology, explore pandemic’s...
Sarcomas represent a heterogeneous group of mesenchymal malignancies that most commonly occur in the extremities, retroperitoneum, and head neck. Intra-abdominal manifestations are rare prove particularly difficult to treat when peritoneal sarcomatosis is present. Because overall poor prognosis disease, tailored approach surgical management essential achieve satisfactory outcomes with limited morbidity. We present perioperative long-term 19 cases sarcoma treated surgically at our hospital....
<b><i>Background:</i></b> Data on institutional structures of sarcoma care in Germany are scarce. The utilization an interdisciplinary tumor board (IDTB) is essential part modern cancer care. We investigated to which extent and when IDTB used hypothesized that before treatment initiation were more often at certified centers high-volume increased over time. <b><i>Methods:</i></b> From 2017 2020 we conducted a prospective cohort study,...
Abstract Purpose One of the major challenges in management patients with septic and non-septic open abdomen (OA) is to control abdominal wall retraction. The aim this study was evaluate impact a novel vertical traction device (VTD) on primary fascial closure (PFC) prevention Methods Twenty treated OA were included retrospective multicenter study. All initially stabilized laparostomy temporarily sealed either Bogotá bag or negative pressure wound therapy system (NPWT). Results mean duration...
Objective The aim of the study was to assess feasibility and potential Global Trigger Tool (GTT) for identifying adverse events (AEs) in different specialties German hospitals. Methods A total 120 patient records were randomly selected from two surgical one neurosurgery departments three university hospitals Germany a period 2 months per department between January July 2017. reviewed using an adaptation version Institute Healthcare Improvement GTT. Results Thirty-nine (32.5%) contained at...
Abstract Objective Fibroblast growth factor receptor (FGFR) 2 regulates the development of adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and enhance proliferation adrenocortical precursor cells. The activation Wingless/Int-1 (WNT)/beta catenin pathway as a key mechanism tumourigenesis linked FGFR2 other cell types. Therefore we hypothesised that expression may also play role carcinoma (ACC). We conducted pilot study analysed protein 26 ACCs...
The Global Trigger Tool (GTT) has become a worldwide used method for estimating adverse events through retrospective patient record review. However, little is known about the facilitators and challenges in GTT-implementation process. Thus, this study followed two aims: First, to apply comprehensive set of feasibility criteria qualitatively systematically assess process three departments German university hospitals. Second, identify obstacles met derive recommendations supporting other...
Background: Current guidelines recommend video-assisted thoracoscopic surgery (VATS) for recurrent primary spontaneous pneumothorax (PSP) and cases with persistent air leak after chest tube treatment. The socioeconomic impact of PSP on the healthcare system is insufficiently reported. Methods: Ninety-six patients treated between 01/2010 01/2020 were included. Forty-eight underwent VATS, while second group received (CT) treatment only. Length hospital stay (LOS), duration tube, prolonged...
Approximately 50-70 % of patients with retroperitoneal or intraabdominal sarcoma develop a relapse after surgical therapy, including peritoneal sarcomatosis, an extremely rare site metastatic disease which is associated poor prognosis. Accordingly, the establishment permanent cell line derived from sarcomatosis might provide helpful tool to understand biological behavior and new therapeutic strategies. Thus, we established characterized liposarcoma (Lipo-DUE1) that was permanently cultured...
Right extended liver resection is frequently required to achieve tumor-free margins. Portal venous embolization (PVE) of the prospective resected hepatic segments for conditioning II/III does not always induce adequate hypertrophy in II and III (future remnant volume (FLRV)) right-resection. Here, we present technique situ split dissection along plus portal disruption IV-VIII (ISLT) as a salvage procedure overcome inadequate gain FLRV after PVE.In eight patients, was further pre-conditioned...
Background: Video-assisted thoracoscopic surgery (VATS) with bullectomy and partial pleurectomy (VBPP) is an increasingly used well-established surgical treatment for primary spontaneous pneumothorax (PSP). However, reports on its effectiveness long-term outcomes are limited. The aim of this study was to assess compare recurrence rates following VBPP chest tube (CT) identify potential risk factors disease in patients PSP. Methods: A total 116 treated either by or CT were included study....
Das stumpfe Abdominaltrauma stellt im Bereich der Notfallversorgung trotz modernster diagnostischer Mittel weiterhin eine Herausforderung dar. Einige möglichen Verletzungen sind unmittelbar nach dem Trauma klinisch inapparent und bildgebend kaum nachweisbar oder treten zweizeitig auf.
Background: Video-assisted thoracoscopic surgery (VATS) with partial pleurectomy is an established treatment for primary spontaneous pneumothorax (PSP). However, postoperative pulmonary function and health-related quality of life (HR-QoL) after VATS–bullectomy (VBPP) have not been elucidated. Methods: Eligible patients were assessed HR-QoL using the Short-Form 36 (SF-36) health survey. Pulmonary (PF) was evaluated by spirometry. We compared results VBPP cohort German national norms, a...
Abstract Background Two-port VATS (2-P-VATS) and three-port (3-P-VATS) are well-established techniques for surgical therapy of primary spontaneous pneumothorax (PSP). However, comparisons both in terms postoperative outcome recurrence limited. Methods From January 2010 to March 2020, we retrospectively reviewed data 58 PSP patients who underwent our institution. For statistical analysis, categorical continuous variables were compared by chi-square test or Fisher’s exact the Student´s t-test,...
Trotz erheblicher medizinischer und chirurgisch technischer Fortschritte ist die Morbidität nach Pankreaseingriffen noch immer vergleichsweise hoch. Die Komplikationsrate liegt weiterhin je Literaturquelle bei 30–50 %. Einen erheblichen Einfluss auf das Outcome haben perioperative Komplikationen wie Pankreasfistel sowie Anastomoseninsuffizienzen, Ausprägung unterschiedliche Therapiemodalitäten erfordern. Diese schließen sowohl konservative als auch interventionelle chirurgische...