A5072132914- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lymphatic Disorders and Treatments
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Vascular Malformations and Hemangiomas
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Surgical Simulation and Training
- Pain Management and Opioid Use
- Liver Disease and Transplantation
- Phagocytosis and Immune Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
Ludwig-Maximilians-Universität München
2015-2024
German Cancer Research Center
2020-2024
Heidelberg University
2020-2024
LMU Klinikum
2015-2024
München Klinik
2015-2023
Massachusetts General Hospital
2018-2020
Harvard University
2018-2020
University of Alabama at Birmingham
2016
University Hospital Ulm
2004
In patients with pancreatic ductal adenocarcinoma (PDAC), the tumor microenvironment consists of cellular and stromal components that influence prognosis. Hence, tumor-infiltrating lymphocytes (TILs) may predict prognosis more precisely than conventional staging systems. Studies on impact TILs are heterogeneous further research is needed. Therefore, this study aims to point out importance peritumoral TILs, neutrophils (TINs), immune subtype classification in PDAC. Material from 57 was...
In the past decade, use of neoadjuvant therapy (NAT) has increased for patients with borderline and locally advanced pancreatic ductal adenocarcinoma (PDAC). Data on fistula related overall survival (OS) in this setting are limited.To compare postoperative complications undergoing either upfront resection or pancreatectomy following NAT, focusing clinically relevant (CR-POPF) potential associations OS.This retrospective cohort study was conducted data from who underwent PDAC at Massachusetts...
Abstract Background An increasing body of evidence suggests that microbiota may promote progression pancreatic ductal adenocarcinoma (PDAC). It was hypothesized gammaproteobacteria (such as Klebsiella pneumoniae) influence survival in PDAC, and quinolone treatment attenuate this effect. Methods This a retrospective study patients from the Massachusetts General Hospital (USA) Ludwig-Maximilians-University (Germany) who underwent preoperative pancreatoduodenectomy for locally advanced or...
Abstract Purpose The short-stitch technique for midline laparotomy closure has been shown to reduce hernia rates, but long stitches remain the standard of care and effect on short-term results is not well known. aim this study was compare two techniques, using an ultra-long-term absorbable elastic suture material. Methods Following elective laparotomy, 425 patients in 9 centres were randomised receive wound (USP 2-0 single thread, n = 215) or long-stitch 1 double loop, 210) with a...
The tumor microenvironment plays an important role in the biology. Overall survival of patients after resection is influenced by tumor-infiltrating lymphocytes (TILs) as a component stroma. However, it not clear how to assess TILs stroma due heterogeneous methods different cancer types. Therefore, we present novel Quantification Tumor immune Stroma (QTiS) Algorithm reliably and accurately quantify cells Immunohistochemical staining CD3 CD8 sections metastatic colorectal (mCRC), ovarian...
Zusammenfassung Einleitung Die neue, vermehrt kompetenzbasierte Weiterbildungsordnung für die chirurgische Weiterbildung (WBO) trat in Bayern im August 2022 Kraft. Methoden Von Mai bis Juli führten wir eine anonymisierte Onlineumfrage unter den bayerischen Allgemein- und Viszeralchirurginnen -cChirurgen sowie Ärzt*innen (ÄiW) durch. Ziel war Erfragung der Erwartungen an Effekte neuen WBO. Ergebnisse Rücklaufquote betrug 35 %; insgesamt konnten Daten von 80 Personen erhoben werden: 36 ÄiW (45...
Abstract Background Non-resectability is common in patients with pancreatic ductal adenocarcinoma (PDAC) due to local invasion or distant metastases. Then, biliary gastroenteric bypasses both are often established despite associated morbidity and mortality. The current study explores outcomes after palliative bypass surgery non-resectable PDAC. Methods From the prospectively maintained German StuDoQ|Pancreas registry, all histopathologically confirmed PDAC who underwent non-resective between...
Background: Our retrospective single-center study aims to evaluate the impact of structured reporting (SR) using a CEUS LI-RADS template on report quality compared conventional free-text (FTR) in contrast-enhanced ultrasound (CEUS) for diagnosis hepatocellular carcinoma (HCC). Methods: We included 50 patients who underwent HCC staging. FTR created after these examinations were SR retrospectively generated by template-based online software with clickable decision trees. The reports evaluated...