A5028076675- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Mycobacterium research and diagnosis
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Evolution and Genetic Dynamics
- Cardiac, Anesthesia and Surgical Outcomes
- Nursing education and management
- Sepsis Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Colorectal Cancer Treatments and Studies
- Neuroblastoma Research and Treatments
- Body Contouring and Surgery
- Myasthenia Gravis and Thymoma
- Obesity and Health Practices
- Surgical site infection prevention
Barnes-Jewish Hospital
2023
Queen Mary University of London
2021-2022
ORCID
2021
Klinikum rechts der Isar
2019-2020
Laboratoire Cognitions Humaine et Artificielle
2020
University Hospital Heidelberg
2015-2019
Heidelberg University
2015-2019
VA Portland Health Care System
2016-2019
Technical University of Munich
2019
The University of Texas MD Anderson Cancer Center
2015
The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters. However, because high interobserver variation some criteria, more reliable prognostic markers are required. Here, we assessed TERT promoter for mutations in hotspot regions C228T C250T meningioma samples from 252 patients. Mutations were detected 16 (6.4% across cohort, 1.7%, 5.7%, 20.0% WHO grade I, II, III cases, respectively). Data...
Abstract Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity 1 . The interplay of these biological processes their respective contributions tumour evolution remain unknown. Here we show that genetic ancestry only infrequently affects gene expression traits subclonal in colorectal cancer (CRC). Using spatially resolved paired whole-genome transcriptome sequencing, find the majority variation is not strongly heritable but rather...
Abstract Colorectal malignancies are a leading cause of cancer-related death 1 and have undergone extensive genomic study 2,3 . However, DNA mutations alone do not fully explain malignant transformation 4–7 Here we investigate the co-evolution genome epigenome colorectal tumours at single-clone resolution using spatial multi-omic profiling individual glands. We collected 1,370 samples from 30 primary cancers 8 concomitant adenomas generated 1,207 chromatin accessibility profiles, 527 whole...
Meningiomas are frequent central nervous system tumors. Although most meningiomas benign (WHO grade I) and curable by surgery, WHO II III tumors remain therapeutically challenging due to recurrence. Interestingly, relapse also occurs in some I meningiomas. Hence, we investigated the transcriptional features defining aggressive (recurrent, malignantly progressing or III) 144 cases. were categorized into non-recurrent (NR), recurrent (R), undergoing malignant progression (M) addition their...
Purpose: To replicate research about confidence level in receiving health teaching from either an overweight or a weight‐appropriate RN. Methods: A quasi‐experimental post‐test only design was used. Participants were randomly assigned to be shown images of nurse, weight‐appropriate, then asked rate their received that nurse. Descriptive statistics, t test for independent samples, and covariate analyses performed. Results: significant difference p=0.000 noted between participants who viewed...
Abstract Purpose: Clinically aggressive meningiomas (MGMs) are rare but treatment-resistant tumors in need for more effective therapies. Because tumor-infiltrating T lymphocytes (TILs) essential successful immunotherapy, we assessed TIL numbers and their activation status primary (p-) recurrent (r-) impact on survival. Experimental Design: Presence of TILs was analyzed 202 clinically well-annotated cases (n = 123 pMGMs n 79 rMGMs) focusing higher-grade [n 97 World Health Organization (WHO)...
Abstract Endoscopic screening for Barrett's esophagus as the major precursor lesion esophageal adenocarcinoma is mostly offered to patients with symptoms of gastroesophageal reflux disease (GERD). However, other epidemiologic risk factors might affect development and adenocarcinoma. Therefore, efforts improve efficiency find population “at risk” compared normal are needed. In a cross-sectional analysis, we 587 from multicenter German BarrettNET registry 1976 healthy subjects population-based...
SUMMARY Risk stratification in patients with Barrett's esophagus (BE) to prevent the development of esophageal adenocarcinoma (EAC) is an unsolved task. The incidence EAC and BE increasing are still at unknown risk. BarrettNET ongoing multicenter prospective cohort study initiated identify validate molecular clinical biomarkers that allow a more personalized surveillance strategy for BE. For participants recruited 20 centers throughout Germany, be followed progression dysplasia (low-grade or...
4635 Background: Our recent meta-analysis of 1st-line GEM when combined with CIS or analogs indicated a significant benefit compared to alone in advanced pancreatic cancer (ASCO 2007: 4515). Based on chemosensitization by RHT we performed prospective single-center phase II trial GEM+CIS under the guidance ESHO (European Society Hyperthermic Oncology). Methods: 22 pts metastatic (n=19) locally (n=3) and disease progression after GEM- based chemotherapy were eligible. Primary endpoint: TTP2...
Abstract Colorectal malignancies are a leading cause of cancer death. Despite large-scale genomic efforts, DNA mutations do not fully explain malignant evolution. Here we study the co-evolution genome and epigenome colorectal tumours at single-clone resolution using spatial multi-omic profiling individual glands. We collected 1,373 samples from 30 primary cancers 9 concomitant adenomas generated 1,212 chromatin accessibility profiles, 527 whole-genomes 297 whole-transcriptomes. found...
Abstract Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which variation within a tumour consequence of intra-tumour genetic heterogeneity remains undetermined. Here we show that colorectal cancer cells frequently have highly plastic traits in vivo patient tumours. We measured degree reflects ancestry quantifying phylogenetic signal gene expression across 297 samples with multi-region paired whole genome and transcriptome...
<p>Fig. S1: Workflow; Fig. S2: Representative gating strategy for TissueFAXS analysis; S3: Analysis of helper, cytotoxic and regulatory T cell infiltration the proportion PD-1-expressing cells; S4: Association between cells survival; S5: Levels tumor-infiltrating lymphocytes (TILs) in meningiomas, separated by their localization.</p>
<p>Supplementary Figure Legends</p>
<div>AbstractPurpose:<p>Clinically aggressive meningiomas (MGMs) are rare but treatment-resistant tumors in need for more effective therapies. Because tumor-infiltrating T lymphocytes (TILs) essential successful immunotherapy, we assessed TIL numbers and their activation status primary (p-) recurrent (r-) impact on survival.</p>Experimental Design:<p>Presence of TILs was analyzed 202 clinically well-annotated cases (<i>n</i> = 123 pMGMs...
<div>AbstractPurpose:<p>Clinically aggressive meningiomas (MGMs) are rare but treatment-resistant tumors in need for more effective therapies. Because tumor-infiltrating T lymphocytes (TILs) essential successful immunotherapy, we assessed TIL numbers and their activation status primary (p-) recurrent (r-) impact on survival.</p>Experimental Design:<p>Presence of TILs was analyzed 202 clinically well-annotated cases (<i>n</i> = 123 pMGMs...
<p>Fig. S1: Workflow; Fig. S2: Representative gating strategy for TissueFAXS analysis; S3: Analysis of helper, cytotoxic and regulatory T cell infiltration the proportion PD-1-expressing cells; S4: Association between cells survival; S5: Levels tumor-infiltrating lymphocytes (TILs) in meningiomas, separated by their localization.</p>
<p>Supplementary Figure Legends</p>