A5077803679- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- IgG4-Related and Inflammatory Diseases
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Innovations in Medical Education
- Advances in Oncology and Radiotherapy
- Health and Medical Research Impacts
- Colorectal Cancer Screening and Detection
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Neuroblastoma Research and Treatments
- AI in cancer detection
- Enhanced Recovery After Surgery
- Opioid Use Disorder Treatment
- Diversity and Career in Medicine
- Biliary and Gastrointestinal Fistulas
- Diabetes Management and Research
- Appendicitis Diagnosis and Management
Massachusetts General Hospital
2018-2025
Harvard University
2019-2025
MGH Institute of Health Professions
2019-2024
Center for Cancer Research
2020-2022
Cambridge University Hospitals NHS Foundation Trust
2022
Addenbrooke's Hospital
2022
Abstract Objective To evaluate the CT and MRI features of pancreatic acinar cell carcinoma (pACC) their association with patient outcome survival. Methods This retrospective single-center study included 49 patients pathology-proven who underwent diagnostic imaging between August 1998 - September 2019. Two radiologists reviewed independently. Survival was estimated using Kaplan-Meier method, Cox proportional-hazards regression model used to identify factors associated Results pACC tended...
Background and aims: Intraductal papillary mucinous neoplasms (IPMNs) are preneoplastic pancreatic lesions that present on a spectrum of histologic phenotypes with variable risk in progressing to invasive cancer. Aberrant repetitive element expression has been shown be functionally linked cell state changes This study utilized spatial transcriptomics customized repeat probes better understand the relationship subtypes, dysregulation, molecular profiles different populations IPMN. Methods: A...
Objective: To examine the impact of hospital volume on mortality and healthcare utilization in patients admitted with necrotizing pancreatitis (NP). Background: Over 20% acute develop NP, which has been associated higher rates procedural intervention, morbidity, mortality. Methods: Adult NP were identified 2016-2019 Nationwide Readmissions Database 2016-2019. Hospital cutoffs defined by tertiles total admissions per year (low-volume [<9 admissions/year]; medium-volume [9-25 high-volume...
Objective: To describe the long-term natural history of Branch duct intraductal papillary mucinous neoplasm (BD-IPMN). Background: The BD-IPMN is a known precursor pancreatic cancer, yet its largely unknown. Methods: We retrospectively reviewed patients with who were followed at Massachusetts General Hospital for least ten years without surgical intervention. Patient and cyst characteristics, development worrisome features (WF), need surgery, malignancy recorded. risk cancer in this cohort...
Objectives We aimed to evaluate the prevalence, impact, and predictors of opioid use disorder (OUD) in hospitalized chronic pancreatitis (CP) patients. Methods A retrospective cohort study was performed using National Inpatient Sample database from 2005 2014. Patients with a primary diagnosis CP OUD were included. The outcome evaluating prevalence trend patients CP. Secondary outcomes (1) assess impact on health care resource utilization (2) identify Results total 176,857 included, present...
We aimed to build a machine learning tool help predict low-grade intraductal papillary mucinous neoplasms (IPMNs) in order avoid unnecessary surgical resection. IPMNs are precursors pancreatic cancer. Surgical resection remains the only recognized treatment for yet carries some risks of morbidity and potential mortality. Existing clinical guidelines imperfect distinguishing low-risk cysts from high-risk that warrant resection.We built linear support vector (SVM) model using prospectively...
Introduction. Low colorectal cancer (CRC) screening rates among Hispanic and Latino patients result in advanced disease at the time of diagnosis decreased survival chances. Methods. We performed a prospective study an academic endoscopy center Boston, Massachusetts from May 1, 2019 to January 31, 2020. identified 887 Spanishspeaking as controls enrolled 412 (59%) Spanish-speaking short message service (SMS) program for pre-procedure instructions. Results. Intervention control group...
Cholecystectomy is the gold standard for most gallbladder-related disease. However, many patients with gallbladder disease are poor surgical candidates. Current nonsurgical drainage (GBD) methods include percutaneous cholecystostomy and endoscopic ultrasound-guided transluminal GBD (EUS-GBD). Outcomes EUS-GBD treatment of noncholecystitis (NC) have not been defined.Cases were identified using procedural data from a quaternary academic hospital procedures 2015 to 2020. Patients who underwent...
Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus pancreatic ductal adenocarcinoma (PDA). To determine interplay between nuclear GSK-3β PDA development, we generated Lox-STOP-Lox (LSL) nuclear-targeted animals crossed them with LSL-KRas G12D mice under control Pdx1-cre transgene—referred to as KNGC. Interestingly, 4-week-old KNGC show profound loss acinar cells, expansion rapid development cystic-like lesions reminiscent...