A5047990263- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Food Security and Health in Diverse Populations
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Homelessness and Social Issues
- Economic and Financial Impacts of Cancer
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound Imaging and Elastography
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
Yale University
2018-2025
Mayo Clinic
2025
WinnMed
2025
Mayo Clinic in Florida
2025
Beth Israel Deaconess Medical Center
2023-2024
Harvard University
2023-2024
Hadassah Medical Center
2024
Health First
2024
Harvard University Press
2023
Yale Cancer Center
2022
To report pancreas surveillance outcomes of high-risk individuals within the multicenter Cancer Pancreas Screening-5 (CAPS5) study and to update patients enrolled in prior CAPS studies.
Abstract Surveillance of individuals at high‐risk pancreatic cancer using CAPS criteria and other expert consensus guidelines may result in earlier detection some cases; therefore, clinicians are responsible for appropriately identifying referring these to appropriate pancreas screening programs. This study aimed assessing the perspective, knowledge, clinical practices genetic counselors surveyed nationwide towards identification utilization One hundred eighty‐nine who listed “Cancer” as...
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery mechanistic understanding of the genetic epigenetic drivers PDAC therefore critical importance. Here, we uncover serine protease inhibitor Kazal type 1 (SPINK1) as putative determinant clinical progression demonstrate that it can have non-canonical function regulator epigenomic states cells associated extensive changes in gene expression. We show SPINK1...
The potential of DNA methylation alterations in early pancreatic cancer (PC) detection among tissue cell-free seems promising. This study investigates the diagnostic capacity 4-gene biomarker panel, which included ADAMTS1, BNC1, LRFN5, and PXDN genes, a case-control study.A genome-wide pharmacoepigenetic approach identified genes as putative targets. Tissue samples including stage I-IV PC (n = 44), intraepithelial neoplasia 15), intraductal papillary mucinous neoplasms 24), normal pancreas...
Identifying branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) at lowest risk of progression may allow for a reduced intensity surveillance.We aimed to externally validate the previously developed Dutch-American Risk stratification Tool (DART-1; https://rtools.mayo.edu/DART/), which identifies cysts low developing worrisome features (WFs) or high-risk stigmata (HRS).Three prospective cohorts individuals under surveillance BD-IPMNs were combined, independent from original...
Gastric outlet obstruction, afferent or efferent limb and biliary obstruction among patients with altered anatomy often require surgical intervention which is associated significant morbidity mortality. Endoscopic dilation for benign etiologies requires multiple sessions, whereas self-expandable metal stents used malignant fail due to tumor in-growth. Lumen apposing stents, placed endoscopically the intent of creating a de-novo gastrointestinal anastomosis bypassing site can potentially...
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present significant diagnostic challenge. While surgical resection IPMN-related advanced neoplasia, i.e., high-grade dysplasia or PC, is an essential early PC detection strategy, not recommended for IPMN-low-grade (LGD) due to minimal risk carcinogenesis, procedural risks. Based their promising results in prior...