A5043389795- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Bariatric Surgery and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Gastrointestinal Tumor Research and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Foreign Body Medical Cases
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Body Contouring and Surgery
- Neuroendocrine regulation and behavior
- Organ Transplantation Techniques and Outcomes
University of Minnesota Medical Center
2015-2025
University of Minnesota System
2025
University of Minnesota
2015-2024
Borland Groover Clinic
2019
University of Utah
2019
Thomas Jefferson University
2019
Johns Hopkins University
2010-2018
University of Colorado Anschutz Medical Campus
2013-2018
Johns Hopkins Medicine
2010-2018
University of Colorado Denver
2013-2015
Cholangiocarcinoma (CCA) presents significant diagnostic challenges, resulting in late patient diagnosis and poor survival rates. Primary sclerosing cholangitis (PSC) patients pose a particularly difficult clinical dilemma because they harbor chronic biliary strictures that are to distinguish from CCA. MicroRNAs (miRs) have recently emerged as valuable class of markers; however, thus far, neither extracellular vesicles (EVs) nor miRs within EVs been investigated human bile. We aimed...
Accurate assessment of gonadal steroid levels in the developing brain is critical for understanding naturally occurring steroid-mediated sexual differentiation as well determining physiological relevance exogenous treatments commonly used study this phenomenon. Using RIA, we measured estradiol (E(2)) content six regions immediately post partum, 1 d and after injection benzoate, testosterone propionate, or aromatase inhibitor formestane. We found sexually dimorphic E(2) several newborn brain....
The mechanisms establishing and maintaining dendritic spines in the mammalian CNS remain primarily unknown. We report a novel mechanism of neuronal spine plasticity developing preoptic area which estradiol induces prostaglandin-E2 (PGE2) synthesis that turn increases density spine-like processes. Estradiol requires PGE2 synthesis, vivo vitro, upregulates protein spinophilin, an effect attenuated by antagonism AMPA-kainate receptor. This signaling pathway may involve cross talk between...
To evaluate the performance characteristics of endoscopic ultrasonography (EUS) compared with computed tomography (CT) and magnetic resonance imaging (MRI) determine incremental diagnostic yield accuracy EUS or without fine needle aspiration (FNA) over CT MRI for prediction neoplastic pancreatic cysts.The database was queried procedures performed cysts between March 2006 January 2010. Cystic ductal adenocarcinoma, cystic neuroendocrine tumor, mucinous neoplasm, intraductal papillary solid...
Our objective was to analyze factors predicting outcomes after a total pancreatectomy and islet autotransplantation (TP-IAT).Chronic pancreatitis (CP) is increasingly treated by TP-IAT. Postoperative are generally favorable, but minority of patients fare poorly.In our single-centered study, we analyzed the records 581 with CP who underwent Endpoints included persistent postoperative "pancreatic pain" similar preoperative levels, narcotic use for any reason, graft failure at 1 year.In...
Observational data on the impact of on-site cytopathology evaluation (OCE) during endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) pancreatic masses have reported conflicting results. We aimed to compare diagnostic yield malignancy and proportion inadequate specimens between patients undergoing EUS-FNA with without OCE.In this multicenter randomized controlled trial, consecutive solid mass underwent randomization for or OCE. The number FNA passes in OCE+ arm was dictated by...
The majority of pancreatic serous cystic neoplasms (SCNs) are benign. However, these can cause symptoms and rarely be aggressive. Identification factors associated with symptomatic or aggressive SCNs may aid management decisions. aim this study was to identify variables that predict SCNs.Prospective pathology database queried for were surgically resected at Johns Hopkins Hospital. Tumors considered if they invaded surrounding structures and/or vessels metastasized lymph nodes distant organs....
Current guidelines for necrotizing pancreatitis (NP) recommend delay in drainage ± necrosectomy until 4 or more weeks after initial presentation to allow collections wall off. However, evidence of infection with clinical deterioration despite maximum support may mandate earlier (<4 weeks) intervention. There are concerns, but scant data regarding risk complications and outcomes early endoscopic Our aim was compare the results an centered step-up approach NP when initiated before versus...
This clinical practice guideline from the American Society for Gastrointestinal Endoscopy provides an evidence-based approach diagnosis of malignancy in patients with biliary strictures undetermined etiology. document was developed using Grading Recommendations Assessment, Development and Evaluation framework addresses role fluoroscopic-guided biopsy sampling, brush cytology, cholangioscopy, EUS strictures. In endoscopic workup these patients, we suggest use sampling addition to cytology...
A feature of the telencephalic vocal control system in budgerigar (Melopsittacus undulatus) that has been hypothesized to represent a profound difference organization from oscine is its reported lack an inherent circuit through anterior forebrain. The present study reports anatomical connections indicate existence forebrain comparable important ways "recursive" pathway songbirds. Results anterograde and retrograde tracing experiments with biocytin fluorescently labeled dextran amines central...
Diagnosis of non-calcific chronic pancreatitis (NCCP) in patients presenting with abdominal pain is challenging and controversial. Contrast-enhanced magnetic resonance imaging (MRI) secretin-stimulated MRCP (sMRCP) offers a safe noninvasive modality to diagnose mild CP, but its findings have not been correlated histopathology. We aimed assess the correlation spectrum MRI/sMRCP surgical histopathology cohort NCCP undergoing total pancreatectomy islet autotransplantation (TPIAT).Adult TPIAT...