A5079586033- Global Health and Surgery
- Global Health Workforce Issues
- Diversity and Career in Medicine
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Global Maternal and Child Health
- Pancreatic and Hepatic Oncology Research
- Congenital Anomalies and Fetal Surgery
- Dental Education, Practice, Research
- Trauma and Emergency Care Studies
- Pluripotent Stem Cells Research
- Child and Adolescent Health
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Patient-Provider Communication in Healthcare
- Histone Deacetylase Inhibitors Research
- Global Cancer Incidence and Screening
- Retinopathy of Prematurity Studies
- Radiation Dose and Imaging
- Scoliosis diagnosis and treatment
- Angiogenesis and VEGF in Cancer
- Social Media in Health Education
- Infectious Diseases and Mycology
Beth Israel Deaconess Medical Center
2024-2025
Yale University
2019-2023
Yale New Haven Hospital
2023
San Juan Bautista School of Medicine
2022
Cornell University
2022
Weill Cornell Medicine
2022
University of Toronto
2022
University of Virginia
2022
Tulane University
2022
Johns Hopkins Medicine
2019-2020
The potential of DNA methylation alterations in early pancreatic cancer (PC) detection among tissue cell-free seems promising. This study investigates the diagnostic capacity 4-gene biomarker panel, which included ADAMTS1, BNC1, LRFN5, and PXDN genes, a case-control study.A genome-wide pharmacoepigenetic approach identified genes as putative targets. Tissue samples including stage I-IV PC (n = 44), intraepithelial neoplasia 15), intraductal papillary mucinous neoplasms 24), normal pancreas...
3046 Background: Prior work has shown that detection of circulating tumor DNA (ctDNA) at time diagnosis leiomyosarcoma (LMS) is associated with lower likelihood objective response and patients detectable ctDNA after two cycles chemotherapy have worse survival. However, because exists much concentrations in plasma compared to cell-free non-tumor origin, the sensitivity these prognostic measures signals remains unclear. With increasing evidence fragments being shorter than background DNA, we...
Abstract Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated naïve epiblast-like state. Naïve diabetic (N-DVP) differentiated patient-specific hiPSC (N-DhiPSC) possessed higher functionality, maintained greater genomic stability, harbored decreased lineage-primed gene expression, were more efficient in...
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present significant diagnostic challenge. While surgical resection IPMN-related advanced neoplasia, i.e., high-grade dysplasia or PC, is an essential early PC detection strategy, not recommended for IPMN-low-grade (LGD) due to minimal risk carcinogenesis, procedural risks. Based their promising results in prior...
Leiomyosarcomas (LMS) are diverse, rare, and aggressive mesenchymal soft tissue sarcomas. Epigenetic alterations influence multiple aspects of cancer, however epigenetic profiling LMS has been limited. The goal this study was to delineate the molecular landscape for subtype-specific differences (uterine (ULMS) vs (STLMS)) based on integrated analysis DNA methylation gene expression identify potential targets therapeutic intervention diagnosis. We identified differentially methylated...
Historically, the US has been largest contributor to development assistance for health (DAH), although its allocation shifted in response outside forces. This included, example, establishment of Millennium Development Goals (MDGs) 2000, which emphasised child mortality, maternal health, HIV/AIDS, and malaria. led funds being earmarked disease-specific interventions rather than system strengthening (HSS). In 2007, World Health Organization (WHO) published six building blocks, representing...
The medical community has increasingly embraced social media for a variety of purposes, including trainee education, research dissemination, professional networking, and recruitment trainees faculty. Platform choice usage patterns appear to vary by specialty purpose, but few studies comprehensively assess programs' presence. Prior assessed general surgery departments' Twitter use omitted additional platforms residency-specific accounts.This study sought broadly characterize the footprint...
A sense of community benefits medical trainees by preserving mental well-being, nurturing collegiality and mentorship, grounding ties with partnering organizations services. Within school, building these support relationships often begins shortly after matriculation. In the current pandemic accompanying shift to a virtual class format, we believe that dedicated effort foster this is crucial for students who otherwise may feel untethered their new learning environment. Here, detail tips...
Growth assessment, which relies on a combination of radiographic and clinical markers, is an integral part decision-making in pediatric orthopaedics. The aim this study to evaluate the accuracy reliability Diméglio skeletal age system using modern cohort patients.A retrospective review was undertaken all patients at large tertiary hospital who had lateral forearm radiographs (before 14 y for females before 16 males). In addition, these height measurements within 60 days their x-ray final...
Purpose: The disparities in pediatric surgical disease burden and the operative backlog resource-limited settings are not well-studied but have been used to evaluate capacity-building needs using Three Delays Model. We evaluated three delays –in care-seeking, accessing care-facilities, receiving adequate care– for patients presenting Pediatric Surgery Outpatient Clinic (PSOPC) at one of two hospitals with a dedicated surgery unit Uganda. Methods: An interviewer-facilitated survey was...
189 Background: Appendiceal Neoplasms are diverse entities which have a variety of clinical presentations, histologic subtypes, biologic behavior, and patient outcomes. Advanced disease at initial diagnosis is not uncommon therapeutic options limited. This study aims to identify potential targets develop epigenetics-based therapeutics/biomarkers. Methods: Archival (FFPE) specimens were collected from 25 patients with histologically confirmed subtyped appendiceal neoplasia 16 age-matched...
ABSTRACT Vascular regenerative therapies with conventional human induced pluripotent stem cells (hiPSC) currently remain limited by high interline variability of differentiation and poor efficiency for generating functionally transplantable vascular progenitors (VP). Here, we report the advantage tankyrase inhibitor-regulated naïve hiPSC (N-hiPSC) significantly improving cell therapies. Conventional reprogrammed from type-1 diabetic donor fibroblasts (DhiPSC) were stably reverted to...
Background: Low-and-middle-income countries(LMICs) like Uganda, where four pediatric surgeons serve a population of 20 million children, face severe shortage surgeons. Most children with surgical emergency are treated by non-specialist rural providers and will never meet surgeon. Here we describe the design implementation locally driven, pilot care course for to address this disparity. Program Report: The was conducted in February December 2018 at two sites Uganda. Modules included...