A5045384350- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Atrial Fibrillation Management and Outcomes
- Single-cell and spatial transcriptomics
- Eosinophilic Disorders and Syndromes
- Genetic factors in colorectal cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Global Cancer Incidence and Screening
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic and Hepatic Oncology Research
- Palliative Care and End-of-Life Issues
- Ethics in medical practice
- Frailty in Older Adults
- Mycobacterium research and diagnosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Multiple and Secondary Primary Cancers
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Economic and Financial Impacts of Cancer
- Renal cell carcinoma treatment
- Photodynamic Therapy Research Studies
- Cancer survivorship and care
- Multiple Myeloma Research and Treatments
Asklepios Klinikum Harburg
2024-2025
University of Rostock
2018-2025
Universitätsmedizin Rostock
2019-2022
University Medical Center
2020
Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections Pneumocystis jirovecii pneumonia (PcP). As resistances increasing worldwide new research reshapes our understanding of the interactions between human host commensals, administration antibacterial prophylaxis has become a matter discussion. This guideline constitutes an update 2013 published Infectious Diseases Working Party (AGIHO) German Society...
Clinical reactivations of herpes simplex virus or varicella zoster occur frequently among patients with malignancies and manifest particularly as stomatitis in acute leukaemia treated intensive chemotherapy lymphoma multiple myeloma. In recent years, knowledge on reactivation rates clinical manifestations has increased for conventional chemotherapeutics well many new antineoplastic agents. This guideline summarizes current evidence herpesvirus solid tumours hematological not undergoing...
Tumors arising in the context of Lynch Syndrome or constitutional mismatch repair deficiency are hypermutated and have a good response towards immune-checkpoint inhibitors (ICIs), including α-PD-L1 antibodies. However, most cases, resistance mechanisms evolve. To improve outcomes prevent development, combination approaches warranted. Herein, we applied combined regimen with an antibody gemcitabine preclinical tumor model to activate endogenous antitumor immune responses. Mlh1−/− mice...
Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution BCT implementation departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. estimated numbers annually treated patients, imaging timepoints techniques, IPA rates, follow-up assessed. In total, 142 physicians from 43 countries participated. specialties...
Abstract Purpose In patients with metastatic pancreatic cancer, after failure of gemcitabine/nab-paclitaxel, this trial compares the efficacy second-line therapy FOLFIRI vs. OFF (1:1 randomisation) cross-over to vice-versa regimen as third-line therapy. Patients and Methods The primary endpoint was PFS (progression-free survival: time from randomization until progression or death) aimed demonstrate non-inferiority vs (non-inferiority margin a hazard ratio (HR) 1.5, power 80% significance...
Abstract Purpose: Confocal laser scanning microscopy (CLSM) is a non-invasive technique for cellular in vivo imaging of the human cornea. CLSM screening was evaluated early detection corneal nerve morphology changes and neuropathogenic events different stage multiple myeloma (MM) patients. As MM patients show disease as well therapy-related neuropathological symptoms, potentially provides tool events. findings were compared with severity peripheral neuropathic (PNP) symptoms. Methods: The...
Introduction Ageing-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co)morbidity, including cancer, thromboembolism and stroke. Interfering with these may delay, stop or reverse morbidity. The aim this study is investigate link between (co)morbidity ageing by exploring biomarkers molecular mechanisms disease-triggered deterioration patients pancreatic ductal adenocarcinoma (PDAC) (thromboembolic) ischaemic stroke (IS)....
Objective The aims of this cross-sectional study were to investigate the knowledge about and experience with exercise as well motivation preferences (e.g. availability) cancer patients participate in training groups. Methods From 11/2017-06/2018, 181 undergoing or completing treatment responded a compiled questionnaire. stage (transtheoretical model behavioural change), exercise-related knowledge, evaluated. Results Knowledge positive effects was not associated higher stages. Higher stages...
Abstract Active cancer by itself but also chemotherapy is associated with an increased risk of cardiovascular disease (CVD) and especially coronary artery (CAD) atrial fibrillation (AF). The frequency CVD, CAD, AF varies depending on comorbidities (particularly in older patients), type, stage, as well the anticancer therapeutic being taken. Many reports exist for drugs AF, robust data are often lacking. Because this, each patient needs individual structured approach concerning thromboembolic...
Objectives To validate and test the generalisability of SASKit-ML pipeline, a prepublished feature selection machine learning pipeline for prediction health deterioration after stroke or pancreatic adenocarcinoma event, by using it to identify biomarkers in chronic disease. Design This is validation study predefined protocol applied multiple publicly available datasets, including longitudinal data from cohorts with type 2 diabetes (T2D), inflammatory bowel disease (IBD), rheumatoid arthritis...
Castrate resistant prostate cancer in men shares several characteristics with canine (PCa). Due to current insufficient therapies, evaluating novel therapeutic agents for late-stage PCa is of considerable interest both species. PDA indolylmaleimides showed anticancer effects neoplastic cell lines. Herein, a comparative characterization PDA-66 and PDA-377 mediated was performed human lines, which also the first detailed these on cells derived from solid tumors general. While only weak growth...
Abdominal venous thromboses are rare thrombotic events with heterogeneous etiologies. They related to myeloproliferative neoplasms (MPNs) in some patients and can occur as first signs of the disease. MPNs characterized by mutations genes Janus kinase 2 (JAK2), leukemia virus oncogene (MPL), calreticulin (CALR).
Abstract Colorectal cancer (CRC) is rare in young patients without a confirmed family history of cancer. Reports an increased prevalence POLD1/POLE mutations with colorectal have raised awareness and support routine genetic testing for early-onset tumors. In cases CRC proven MMR-germline mutation, molecular analyses are warranted to confirm or rule out other familial syndromes. This article describes the two male patients, who presented locally advanced metastatic CRC, reports results...
Abstract Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly diagnostics previous studies mainly sequencing common PCR techniques under conventional detection limits used. Splanchnic vein thromboses rare, but often appear associated with myeloproliferative represent serious complications. Herein, blood from patients abdominal Mecklenburg-West Pomerania (federal district of northern Germany), included an ongoing prospective prevalence study, was...
<br>Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening episodes. There no established recommendation for the perioperative management of patients scheduled cardiac surgery. We have described patient FVII treated aortic valve stenosis, coronary artery disease, and atrial fibrillation. Balancing risk risks thrombotic events thereafter in such difficult requires multidisciplinary approach.<br>