A5007288012- Advanced Breast Cancer Therapies
- Cardiac electrophysiology and arrhythmias
- Immune cells in cancer
- Advanced Biosensing Techniques and Applications
- Nanofabrication and Lithography Techniques
- Cardiomyopathy and Myosin Studies
- Advanced machining processes and optimization
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Breast Cancer Treatment Studies
- Cancer-related cognitive impairment studies
Universitätsmedizin Greifswald
2022-2024
German Centre for Cardiovascular Research
2024
By a classical approach, the invasive margins of colorectal carcinomas can be typed as expansive or infiltrative, latter portending poor prognosis. Colorectal with infiltrative-type have long been known for their peculiar stroma and relative absence lymphohistiocytic host response, but they not studied contemporary gene expression techniques. Therefore, we submitted 18 microsatellite-stable that could having infiltrative (N = 7) type 11) confidence to nanoString nCounter® analysis (Tumor...
Mismatch repair-deficient (dMMR) tumors show a good response toward immune checkpoint inhibitors (ICI), but developing resistance impairs patients' outcomes. Here, we compared the therapeutic potential of an α-PD-L1 antibody with CDK4/6 inhibitor abemaciclib in two preclinical mouse models dMMR cancer, focusing on immune-modulatory effects either treatment. Abemaciclib monotherapy significantly prolonged overall survival Mlh1-/- and Msh2loxP/loxP;TgTg(Vil1-cre) mice (Mlh1-/-: 14.5 wks vs....
The 5-year survival rate for head and neck squamous cell carcinoma (HNSCC) is approximately 65%. In addition to radio-chemotherapy, immunotherapy an approach in the treatment of advanced HNSCC. A better understanding immune context would allow personalized by identifying patients who are best suited different options. our discovery cohort, we evaluated expression profiles CMTM6, PD-L1, CTLA-4, FOXP3 177 HNSCCs from Caucasian all tumor stages regimens, correlating marker cells with outcomes....
A better understanding of the underlying pathomechanisms diastolic dysfunction is crucial for development targeted therapeutic options with aim to increase patients' quality life. In order shed light on processes involved, suitable models are required. Here, effects endothelin-1 (ET-1) treatment cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) were investigated. While it well established, that ET-1 induces hypertrophy in cardiomyocytes, resulting changes cell...