A5048251137- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- Oral and Maxillofacial Pathology
- Virus-based gene therapy research
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Prostate Cancer Treatment and Research
- Genital Health and Disease
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Microscopic Colitis
University of Rostock
2022-2025
Universitätsmedizin Rostock
2024-2025
University Medical Center
2022
Nuremberg Hospital
2019
Abstract Objectives The World Health Organization's definition of oral epithelial dysplasia includes differentiated dysplasia, which is defined by purely architectural abnormalities mucosa without cytological changes. We analysed dysplasia's frequency, progression risk and correlation with brush cytology. Materials Methods Cytoarchitectural criteria expression patterns keratin 13/17 ki67 were studied in biopsies clinically diagnosed leukoplakia. Biopsies assessed for its grade. Available...
Upper tract urothelial carcinoma (UTUC) accounts for 5-10% of all UCs. Immune checkpoint inhibitors (ICIs) have been established The prognostic and predictive potential programmed cell death ligand 1 (PD-L1) expression to stratify patients benefiting from ICIs is not fully understood, additional markers influencing the impact PD-L1-mediated ICI response are needed. Previously, chemokine-like MARVEL transmembrane domain-containing protein 6 (CMTM6) was identified as a positive regulator...
Abstract Here, we show that combined use of the EZH2 inhibitor GSK126 and CDK4/6 abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation CalR translocation, accompanied by massive impairment mitochondrial function. Basal oxygen consumption rate, ATP synthesis, maximal respiration decreased, confirming disrupted endoplasmic reticulum-mitochondrial homeostasis. This was paralleled depolarization UPR sensors PERK, ATF6α, IRE1α....
Neuroendocrine carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide-based chemotherapy regimens (PE) commonly applied in first-line for advanced disease, evidence second-line therapy beyond is very limited.Retrospective analysis all patients NEPCs including mixed differentiation adenocarcinoma component well differentiated neuroendocrine (NETs, carcinoids) at two high-volume oncological centers between 12/2000 11/2017.Of 46 identified 39.1 %...
The 5-year survival rate for head and neck squamous cell carcinoma (HNSCC) is approximately 65%. In addition to radio-chemotherapy, immunotherapy an approach in the treatment of advanced HNSCC. A better understanding immune context would allow personalized by identifying patients who are best suited different options. our discovery cohort, we evaluated expression profiles CMTM6, PD-L1, CTLA-4, FOXP3 177 HNSCCs from Caucasian all tumor stages regimens, correlating marker cells with outcomes....
This study aimed to refine combined targeted approaches on well-characterized, low-passage tumor models. Upon in vivo xenografting immunodeficient mice, three cell lines from locally advanced or metastatic HNSCC were established. Following quality control and basic characterization, drug response was examined after therapy with 5-FU, Cisplatin, cyclin-dependent kinase inhibitors (abemaciclib, THZ1). Our showed different vitro growth kinetics, morphology, invasive potential, radiosensitivity....
Abstract High hydrostatic pressure specifically devitalizes cells and tissues without major changes in their molecular structure. Hence, high may enhance the development of whole-cell anti-tumor vaccines, representing tumor heterogeneity thus (neo-) antigen diversity. Moreover, safe devitalization tumor-infiltrated supporting tissue facilitate reimplantation for functional reconstruction. However, precise thresholds cancer cell killing are unknown. Here, we show that at least 315 MPa is...
The “Cellular Dissociation Grade” (CDG) is based on tumor cell budding and nest size. Many studies have examined the CDG in squamous carcinomas of other organs such as lungs, oral cavity, pharynx, larynx, cervix esophagus. In this study, was 109 cases invasive penile carcinoma that were treated at University Medicine Rostock between 2014 2022. Furthermore, its correlation with pathologic status regional lymph nodes (pN) main prognostic factor verified. Finally, cellular dissociation grading...
Abstract Background Human papillomavirus (HPV) is an increasing risk factor for cancer. HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC) associated with a favorable outcome. Blockstaining p16 surrogate marker HPV+ OPSCC. In oral and laryngeal (OSCC/LSCC), the relevance of immunohistochemistry, alone or in combination other cycle‐related proteins, to identify HPV‐driven non‐OPSCC less well understood. Methods We stained p16, pRb, cyclin D1, p53 327 HNSCC. 310 OPSCC, HPV‐status was...
Introduction Patient-derived xenografts preserve the histomorphology and molecular pathology of patient tumors. Thus, PDX better represent therapy response than conventional cell line-derived models. Despite these advantages, have not gained widespread acceptance in preclinical research. Reasons are limited material availability, low growth rates mouse models, need to limit animal testing. Therefore, aim this study was generate from head neck tumors CAM assay.
Einleitung Patienten-abgeleitete Xenografts erhalten die Histomorphologie und Molekularpathologie der Patiententumoren. Dadurch repräsentieren PDX das Therapieansprechen besser als herkömmliche Zelllinien-abgeleitete Modelle. Trotz dieser Vorteile haben sich nicht in präklinischen Forschung durchgesetzt. Gründe sind eingeschränkte Materialverfügbarkeit, geringes Anwachsen im Mausmodell Notwendigkeit Tierversuche zu beschränken. Ziel Studie war daher, von Kopf-Hals-Tumoren CAM Assay generieren.
Abstract The current standard of care for the definitive surgical treatment complicative ulcerative colitis is a continence-preserving proctocolectomy with creation an ileal pouch anal anastomosis. In addition to structural and functional disorders, pouchitis J-pouch common phenomenon, typically well responsive antimicrobial therapy. However, sometimes chronic antibiotic-refractory occurs, most often due not completely understood multifactorial pathomechanisms. While high-quality evidence...
Abstract We retrospectively analyzed 129 treatment-naïve head and neck squamous cell carcinomas (HNSCCs) for the expression of programmed death ligand 1 (PD-L1), CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6), tumor-infiltrating leukocytes (TILs), tumor-associated macrophages (TAMs). evaluated relationships among these markers, human papilloma virus (HPV) status, overall survival (OS). PD-L1 CMTM6 (combined positive score (CPS) ≥ 5) were detected in ~ 70% HNSCCs. HPV status had...
Abstract The predictive potential of immunological markers are not fully understood in head and neck squamous cell carcinomas (HNSCC). We retrospectively analyzed 129 treatment-naive HNSCCs for programmed death ligand 1 (PD-L1) CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) expression, tumor-infiltrating leukocytes (TILs), tumor-associated macrophages (TAMs). evaluated mutual relationships among these markers, HPV-status, overall survival (OS). PD-L1 CMTM6 expression (combined...