A5021504466- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Nosocomial Infections in ICU
- Otolaryngology and Infectious Diseases
- Bacterial Genetics and Biotechnology
- Microscopic Colitis
- Genomics and Phylogenetic Studies
- Botulinum Toxin and Related Neurological Disorders
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Osteomyelitis and Bone Disorders Research
- Escherichia coli research studies
- Cardiac, Anesthesia and Surgical Outcomes
- Food Safety and Hygiene
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Vasculitis and related conditions
- Planetary Science and Exploration
- Infection Control in Healthcare
- Phytochemical Studies and Bioactivities
- Enterobacteriaceae and Cronobacter Research
German Center for Infection Research
2020-2024
University Hospital Cologne
2019-2024
University of Cologne
2019-2024
Centrum für Integrierte Onkologie
2024
Institute of Medical Microbiology and Hygiene
2024
Klinikum Ludwigsburg
2023
Oxford University Hospitals NHS Trust
2023
Species within the Enterobacter cloacae complex (ECC) include globally important nosocomial pathogens. A three-year study of ECC in Germany identified xiangfangensis as most common species (65.5%) detected, a result replicated by examining global pool 3246 isolates. Antibiotic resistance profiling revealed widespread and heteroresistance to antibiotic colistin detected mobile (mcr)-9 gene 19.2% all We show that properties depend on chromosomal arnBCADTEF cassette whose products catalyze...
Background. The Wessex Renal Unit serves a large stable population (2.5 million). Pauci‐immune rapidly progressive glomerulonephritis (RPGN) is frequent cause of acute renal failure requiring admission to our unit (∼8%). At level, little known the epidemiology and outcome RPGN. Methods. Between 1 April 1986 31 March 1996, 141 cases biopsy proven pauci‐immune RPGN were seen in region. records 128 patients reviewed. Median (range) follow‐up was 1.8 (0.9–9.64) years from diagnosis. Results....
To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany.
Escherichia coli can cause infections in the urinary tract and normally sterile body sites leading to invasive E. disease (IED), including bacteraemia sepsis, with older populations at increased risk. We aimed estimate theoretical coverage rate by ExPEC4V 9V vaccine candidates. In addition, we better understanding diversity of isolates, their genetic phenotypic antimicrobial resistance (AMR), sequence types (STs), O-serotypes bacterial population structure.
To analyse the rectal carriage rate and molecular epidemiology of vancomycin-resistant Enterococcus faecium (VREfm) recovered from patients upon hospital admission.Adult were screened at six German university hospitals five different federal states admission for colonization with VREfm between 2014 2018. Molecular characterization was performed by WGS followed MLST core-genome analysis.Of 16350 recruited, 263 colonized VREfm, increasing prevalence rates during 5 year study period (from 0.8%...
To analyse the epidemiology and population structure of third-generation cephalosporin-resistant (3GCR) carbapenem-resistant (CR) Klebsiella pneumoniae complex isolates, patients were screened for rectal colonisation with 3GCR/CR K. on admission to six German university hospitals (2016-2019). Also collected susceptible isolates from bloodstream infections (2016-2018). Whole-genome sequencing was performed followed by multilocus typing (MLST), core-genome MLST, resistome virulome analysis....
Five commercially available selective agar were evaluated regarding sensitivity and specificity to detect vancomycin-resistant Enterococcus (E.) faecium. Altogether 187 E. faecium strains included, comprising 119 van-carrying (phenotypically n = 105; phenotypically vancomycin-susceptible VVE-B 14) 68 isolates. Limit of detection was calculated for each pure cultures, stool suspensions artificial rectal swabs. After 24-h incubation ranged between 91.6% 95.0%. It increased in 2 out 5 after...
Abstract Purpose Bone and joint infections are an important increasing problem. Whether intraoperatively detected bacteria should be considered relevant or not is often difficult to assess. This retrospective cohort study analyzes the relevance of C. acnes cultured from deep intraoperative specimens. Methods All tissue samples collected between 2015 2020 a quartiary care provider were evaluated for detection its therapeutical consequences. Infection rates determined according standardized...
Abstract Vancomycin-resistant Enterococcus faecium (VRE) presents significant challenges in healthcare, particularly for hospitalized and immunocompromised patients, including astronauts with dysregulated immune function. We investigated 42 clinical E. isolates simulated microgravity (sim. µ g ) using a 2-D Clinostat, standard gravity conditions (1 as control. Isolates were tested against 22 antibiotics characterized biofilm formation desiccation tolerance. Results showed varied responses...
Abstract Objectives The increasing prevalence of VRE necessitates their reliable detection, especially for low-level resistance mediated by vanB in Enterococcus faecium. In this prospective study we analysed if vanB-mediated vancomycin can be reliably detected Vitek2. Methods One thousand, three hundred and forty-four enterococcal isolates from routine clinical specimens were tested Vitek2 (bioMérieux, Nürtingen, Germany). Additionally, a bacterial suspension (with turbidity equivalent to...
A Wetsch 3,4 Coffee is an easily available stimulant that sustains the workforce.Healthcare workers in particular are renowned for their coffee dependence, and machines found break rooms or at employees' home well used-and regularly touched by bare hands.Fig 1 | Sampling re-enactment.A: drip tray; B: outlet; C: buttons; D:
Background: Bloodstream infections increase morbidity and mortality in hospitalized patients pose a significant burden for health care systems worldwide. Optimal blood culture diagnostics are essential early detection specific treatment. After assessing the quality parameters at surgical intensive unit six months, we implemented diagnostic stewardship bundle (DSB) to optimize then reevaluated its effects after months. Material Methods: All ≥18 years old on ward were included: pre-DSB 137...
Abstract Objectives To analyse the influence of antibiotic consumption on healthcare-associated healthcare onset (HAHO) Clostridioides difficile infection (CDI) in a German university hospital setting. Methods Monthly ward-level measured DDD/100 patient days (pd) and CDI surveillance data from five hospitals period 2017 through 2019 were analysed. Uni- multivariable analyses performed with generalized estimating equation models. Results A total 225 wards 7347 months 4 036 602 pd...
<title>Abstract</title> Objectives To analyse recent epidemiological trends of bloodstream infections (BSI) caused by <italic>Enterococcus</italic> spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study was analysed. Patients presenting with <italic>E. faecium</italic> or faecalis</italic> blood cultures six German university hospitals between October 2016 and June 2020 were prospectively evaluated....
Abstract Objectives To assess incidence rates of surgical site infections (SSI) by MRSA and to determine related factors clinical outcome compared MSSA, including country-specific, institutional patient determinants. Patients methods We performed a subgroup analysis the Europe-wide SALT (NCT03353532) study population with SSI from 14 centres in France, Germany, Italy, Spain UK. Results An overall 0.06% (n = 104) was found 178 903 patients undergoing invasive surgery 2016. Frequently observed...
A parotid abscess (PA) is a complication of an acute bacterial parotitis with potentially life-threatening course. Data on the diagnosis and therapy PA sparse. We aimed at comprehensively analyzing microbiological spectrum therapeutic management. retrospectively identified all patients surgically treated for two tertiary care centers in Germany. demographics, clinical management microbiology were analyzed their statistical association complications recurrence. Overall, 85 included. Most...
Als Komplikation einer akuten bakteriellen Parotitis hat der Parotisabszess (PA) einen potenziell lebensbedrohlichen Verlauf. Abgesehen von Fallserien ist die Datenlage knapp. Ziel dieser Studie war umfassende Analyse des mikrobiologischen Spektrums und therapeutischen Managements bei PA.. In zwei Zentren tertiären Versorgungsstufe in Deutschland wurden retrospektiv alle Patienten mit PA identifiziert. Klinische, demographische mikrobiologische Daten extrahiert Rate an Komplikationen...
<title>Abstract</title> <bold>Background.</bold> A parotid abscess (PA) is a complication of an acute bacterial parotitis with potentially life-threatening course. To date, data on the diagnosis and therapy PA sparse mostly consists case reports or series. Therefore, this study aimed at comprehensively analyzing microbiological spectrum therapeutic management in bi-institutional setting. <bold>Methods.</bold> retrospective clinical chart review was performed to identify all patients...
Abstract Background A parotid abscess (PA) is a complication of an acute bacterial parotitis with potentially life-threatening course. To date, data on the diagnosis and therapy PA sparse mostly consists case reports or series. Therefore, this study aimed at comprehensively analyzing microbiological spectrum therapeutic management in bi-institutional setting. Methods retrospective clinical chart review was performed to identify all patients surgically treated for two tertiary care centers...