A5048532016- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Biochemical and Structural Characterization
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Yersinia bacterium, plague, ectoparasites research
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Pneumonia and Respiratory Infections
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Salmonella and Campylobacter epidemiology
- Microbial Metabolism and Applications
- Travel-related health issues
- Viral Infections and Vectors
- Infectious Diseases and Tuberculosis
- Vibrio bacteria research studies
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
University Hospital Münster
2016-2025
Sierra Leone Agricultural Research Institute
2022-2025
University of Münster
2011-2024
Centre de Recherche Médicales de Lambaréné
2012-2024
Namazi Hospital
2024
University of Tübingen
2012-2024
Chang Gung Memorial Hospital
2018
Linkou Chang Gung Memorial Hospital
2018
Institute of Medical Microbiology and Hygiene
2016-2017
Albert Schweitzer Hospital
2011-2015
Pigs, cattle and poultry are colonized with MRSA the zoonotic transmission of such to humans via direct animal contact, environmental contaminations or meat a matter concern. Livestock-associated (LA) mostly belonging clonal complex (CC) 398 as defined by multilocus sequence typing. However, other lineages including CC5, CC9 CC97 have also been detected in livestock animals Germany. Within framework Dutch-German network project (EUREGIO), 14,036 isolated from clinical screening specimens...
We define two novel species of the genus Staphylococcus that are phenotypically similar to and have near identical 16S rRNA gene sequences aureus. However, compared S. aureus each other, species, argenteus sp. nov. (type strain MSHR1132(T) = DSM 28299(T) SSI 89.005(T)) schweitzeri FSA084(T) 28300(T) 89.004(T)), demonstrate: 1) at a whole-genome level considerable phylogenetic distance, lack admixture, average nucleotide identity <95 %, inferred DNA-DNA hybridization <70 %; 2) different...
The anterior nares are an important reservoir for opportunistic pathogens and commensal microorganisms. A barcoded Illumina paired-end sequencing method targeting the 16S ribosomal RNA V1-2 hypervariable region was developed to compare bacterial diversity of across distinct human populations (volunteers from Germany vs a Babongo Pygmy tribe, Africa). Of 251 phylotypes detected, 231 could be classified genus level 109 species level, including unambiguous identification ubiquitous...
ABSTRACT The role of antibiotics in treatment enterohemorrhagic Escherichia coli (EHEC) infections is controversial because concerns about triggering hemolytic-uremic syndrome (HUS) by increasing Shiga toxin (Stx) production. During the recent large EHEC O104:H4 outbreak, antibiotic therapy was indicated for some patients. We tested a diverse panel to which outbreak strain susceptible interrogate effects subinhibitory concentrations on induction stx 2 -harboring bacteriophages,...
Significance USA300 is a hypervirulent, community-acquired, multidrug-resistant Staphylococcus aureus clone that started to spread in the United States around 17 years ago. Many studies detected it also South America, Europe, and Asia-Pacific region. In this study, we show circulating sub-Saharan Africa. Locating temporal spatial origin of clonal lineages important with respect epidemiology molecular evolution pathogens. We evolved from less virulent resistant ancestor Central Europe 160...
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without contact (CA-MRSA) or livestock (LA-MRSA). The impact on whole MRSA population was assessed a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 isolates infection carriage during two sampling periods 2004 2005 and 2010 2011. Patient-related data were using standardized questionnaire. Methicillin resistance...
ABSTRACT Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was recognized in Europe and worldwide the late 1990s. Within a decade, several genetically geographically distinct CA-MRSA lineages carrying small SCC mec type IV V genetic elements Panton-Valentine leukocidin (PVL) emerged around world. In Europe, predominant strain belongs to clonal complex 80 (CC80) is resistant kanamycin/amikacin fusidic acid. CC80 first reported 1993 but relatively rare until It has since...
ObjectivesCo-trimoxazole (trimethoprim/sulfamethoxazole) is clinically valuable in treating skin and soft tissue infections (SSTIs) caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA). The genetic basis of emerging trimethoprim/sulfamethoxazole resistance S. from Africa unknown. Such knowledge essential to anticipate its further spread. We investigated the molecular epidemiology trimethoprim collected imported Africa.
Reintroduction of sanctuary apes to natural habitat is considered an important tool for conservation; however, reintroduction has the potential endanger resident wild through introduction human pathogens. We found a high prevalence drug‐resistant, human‐associated lineages S taphylococcus aureus in chimpanzees ( P troglodytes ) from Zambia and Uganda. This pathogen associated with skin soft tissue diseases severe invasive infections (i.e. pneumonia septicemia). Colonization by this bacterium...
Abstract Background Physicians depend on reliable information the local epidemiology of infection and antibiotic resistance rates to guide empiric treatment in critically ill patients. As these data are scarce for Central Africa, we performed a retrospective analysis microbiological findings from secondary care hospital Gabon. Methods Microbiological reports 2009 2012 were used assess non-susceptibility three most common isolates six major types infections (bloodstream, ear-eye-nose-throat,...
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are sporadically reported from infections in sub-Saharan Africa. Travellers returning the tropics have a high risk of ESBL-E colonization, which suggests prevalence Our objective was to assess burden rectal colonization and associated factors Gabon, Central Africa We performed cross-sectional study on 200 hospitalized children Africa, applied standardized questionnaire factors. The antimicrobial resistance type β-lactamase...
The disinfection of drinking water by chlorination has in recent years come under closer scrutiny because the potential hazards associated with production stable chlorinated organic chemicals. Organic chemical contaminants are common to all supplies and it is now well-established that by-products obtained conditions disinfection, or during tertiary treatment sewage whose products can ultimately find their way into supplies. Naturally occurring humic substances which invariably present waters...
Staphylococcus aureus is a bacterium that colonizes and infects both humans animals. As little known about the phenotypic molecular characteristics of S. from wild animals in sub-Saharan Africa, objective study was to characterize isolates wildlife analyse if they differed those found among humans. The resistance penicillin low non-human primates (2.9%). Phylogenetic analysis based on concatenated sequences multilocus sequence typing revealed two highly divergent groups isolates. One group...
Background GMZ2 is a fusion protein of Plasmodium falciparum merozoite surface 3 (MSP3) and glutamate rich (GLURP) that mediates an immune response against the blood stage parasite. Two previous phase I clinical trials, one in naïve European adults malaria-exposed Gabonese showed was well tolerated immunogenic. Here, we present data on safety immunogenicity to five year old children, target population for future malaria vaccine efficacy trials. Methodology/Principal Findings Thirty children...