A5010820385- Mobile Health and mHealth Applications
- Scientific Computing and Data Management
- Cancer survivorship and care
- Business Process Modeling and Analysis
- Medication Adherence and Compliance
- Palliative Care and End-of-Life Issues
- Bioinformatics and Genomic Networks
- Machine Learning in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Health and Medical Studies
- Research Data Management Practices
- Ethics in Clinical Research
- Digital Mental Health Interventions
- Data Quality and Management
- Privacy-Preserving Technologies in Data
- Biomedical Text Mining and Ontologies
- Electronic Health Records Systems
- Health Literacy and Information Accessibility
- Pharmaceutical studies and practices
- Bacterial biofilms and quorum sensing
- Cloud Data Security Solutions
- Behavioral Health and Interventions
- Interdisciplinary Research and Collaboration
- Delphi Technique in Research
- Radiation Dose and Imaging
Heilbronn University
2013-2024
The nares represent an important bacterial reservoir for endogenous infections. This study aimed to assess the prevalence of nasal colonization by different pathogens, associated antimicrobial susceptibility and risk factors. We performed a prospective cohort among 1878 nonhospitalized volunteers recruited from general population in Germany. Participants provided swabs at three time points (each separated 4-6 months). Staphylococcus aureus, Enterobacteriaceae nonfermenters were cultured...
COVID-19 has challenged the healthcare systems worldwide. To quickly identify successful diagnostic and therapeutic approaches large data sharing are inevitable. Though organizational clinical abundant, many of them available only in isolated silos largely inaccessible to external researchers. overcome tackle this challenge university medicine network (comprising all 36 German hospitals) been founded April 2020 coordinate action plans, strategies collaborative research activities. 13...
Common syntax and data semantics are core components of healthcare interoperability standards. However, interoperable exchange processes also needed to enable the integration existing systems between organizations. While solutions for delivery available have been widely adopted, support targeting bio-medical research is limited. Our Data Sharing Framework creates a platform implement like cohort size estimation, reviews approvals proposals, consent checks, record linkage, pseudonymization...
The majority of radiological reports are lacking a standard structure. Even within specialized area radiology, each report has its individual structure with regards to details and order, often containing too much non-relevant information the referring physician is not interested in. For gathering relevant clinical key parameters in an efficient way or support long-term therapy monitoring, structured reporting might be advantageous.Despite new technologies medical systems, still dynamic. To...
The treatment for cancer can have a negative impact not only on physical well-being but also mental health and the quality of life (QoL). Health apps enable monitoring different parameters, to date, there are few that support patients with none focuses assessment QoL. Furthermore, as stakeholders often integrated at late stage development process, if all.The aim this research was develop evaluate smartphone app (Lion-App) autonomously measure QoL an iterative, user-centered approach.Patients...
Goal: Knowledge about sex/gender aspects in medicine is often lacking, even though this serves as base for individualized patient-centered care. Thus we developed an online exchange platform on sex and gender medicine: "GenderMed-Wiki" [www.gendermed-wiki.de]. This was funded by the German Federal Ministry of Education Research (BMBF; FKZ: 01FP1506). Our goal to facilitate integration all areas medicine. Therefore evaluated if suitable provide knowledge adequately. Methods: Qualitative...
Medication is the most common intervention in health care, and number of online consumer information systems within pharmaceutical sector increasing. However, can be a barrier for users, imposing asymmetries between stakeholders.The objective this study was to quantify compare usability an medication system (OCMIS) against reference implementation based on interoperable model patients, physicians, pharmacists.Quantitative qualitative data were acquired from pharmacists study. We administered...
For calculated initial antifungal therapy, knowledge on parallel and cross-resistances are vitally important particularly in the case of multiresistant isolates. Based a strain collection 1,062 yeast isolates from German/Austrian multicentre study, susceptibility pattern analysis (SPA) was used to determine proportion eight agents (AFAs) encompassing flucytosine, amphotericin B, azoles (fluconazole, voriconazole posaconazole) echinocandins (caspofungin, micafungin anidulafungin). A total 414...
The integration of routine medical care data into research endeavors promises great value. However, access to this extra-domain is constrained by numerous technical and legal requirements. German Medical Informatics Initiative (MII) - initiated the Federal Ministry Research Education (BMBF) making progress in setting up Data Integration Centers consolidate stored clinical primary information systems. Unfortunately, for many questions cross-organizational sources are required, as one...
Availability and accessibility are important preconditions for using real-world patient data across organizations. To facilitate enable the analysis of collected at a large number independent healthcare providers, syntactic- semantic uniformity need to be achieved verified. With this paper, we present transfer process implemented Data Sharing Framework ensure only valid pseudonymized is transferred central research repository feedback on success or failure provided. Our implementation used...
Personalized medicine enables precise tumor treatment for a patient’s molecular genetic profile. To devise optimal targeted plans patients in board, physicians must consider alterations on gene- and proteins levels but also cancer cell phenotypes. Machine learning can uncover buried patterns, extract pivotal information, unveil corresponding insights from available data. Publicly datasets provide the amounts of data necessary. This work outlines efficacy various machine algorithms which...
Advanced cancer treatments increase survival rates and with that the importance of Quality Life (QoL). QoL is well studied in trials, but transition to standard care little. For this reason, we identified challenges for a regular integration conceptualize an applicable solution together patients health professionals (HP). We conducted two meetings based on design thinking method. Two Physicians, one employee counseling centers, psycho-oncologists, five were included. Based discussions system...
Introduction: Trial recruitment is a crucial factor for precision oncology, potentially improving patient outcomes and generating new scientific evidence. To identify suitable, biomarker-based trials patients’ clinicians need to screen multiple clinical trial registries which lack support modern designs offer only limited options filter in- exclusion criteria. Several provide information but are regarding factors like timeliness, quality of capability semantic, terminology enhanced searching...
Introduction: With the establishment of Data Sharing Framework (DSF) as a distributed business process engine in German research networks, it is becoming increasingly important to coordinate authentication, authorization, and role information between peer-to-peer network components. This provided form an allowlist. paper presents concept implementation Allowlist Management Application. State Art: In networks using DSF, allowlists were initially generated manually. Concept: The Application...
In this paper we present a method for processing EHR data into longitudinal model and examples using to identify patients cross-sectionally longitudinally as well testing study designs retrospectively. Our describes measurements on four dimensions: the associated patient, observed feature, source time of survey. The transformation structured our is defined by rules written in XML. To showcase flexibility proposed model, an evolution retrospective design example interpreting biomarkers...
Quality of life (QoL) is affected by environmental influences and varies between patients. A combined measurement through Patient Reported Outcomes (PROs) Generated Data (PGD) may enhance the detection QoL impairments a longitudinal survey. Leveraging different approaches techniques, challenge to combine data in standardized, interoperable way. We developed an app (Lion-App) semantically annotate from sensor systems as well PROs be merged overall analysis QoL. FHIR implementation guide was...
Abstract BackgroundThe Federal Ministry of Research and Education funded the Network University Medicine for establishing an infrastructure pandemic research. This includes development a COVID-19 Data Exchange Platform (CODEX) that provides standardised harmonised data sets Nearly all university hospitals in Germany are part project transmit medical from local integration centres to CODEX platform. The on person has been collected at several sites is be made available platform merged form....
<sec> <title>BACKGROUND</title> The treatment for cancer can have a negative impact not only on physical well-being but also mental health and the quality of life (QoL). Health apps enable monitoring different parameters, to date, there are few that support patients with none focuses assessment QoL. Furthermore, as stakeholders often integrated at late stage development process, if all. </sec> <title>OBJECTIVE</title> aim this research was develop evaluate smartphone app (Lion-App)...