A5073184134- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Gut microbiota and health
- Probiotics and Fermented Foods
- Streptococcal Infections and Treatments
- Parasitic Diseases Research and Treatment
- Infections and bacterial resistance
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Parasite Biology and Host Interactions
- Escherichia coli research studies
- Antibiotic Use and Resistance
- Bacteriophages and microbial interactions
- Health and Medical Studies
- Salmonella and Campylobacter epidemiology
- Listeria monocytogenes in Food Safety
- Anorectal Disease Treatments and Outcomes
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Amoebic Infections and Treatments
- Nosocomial Infections in ICU
- Mollusks and Parasites Studies
- Microbial Inactivation Methods
Justus-Liebig-Universität Gießen
2016-2025
German Center for Infection Research
2014-2025
Centro de Investigação em Biodiversidade e Recursos Genéticos
2022
Universidade do Porto
2022
Universitätsklinikum Gießen und Marburg
2022
University of Freiburg
2022
German Center for Lung Research
2018
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
University Children's Hospital Tübingen
2017
Whole genome sequencing of bacteria has become daily routine in many fields. Advances DNA technologies and continuously dropping costs have resulted a tremendous increase the amounts available sequence data. However, comprehensive in-depth analysis resulting data remains an arduous time-consuming task. In order to keep pace with these promising but challenging developments transform raw into valuable information, standardized analyses scalable software tools are needed. Here, we introduce...
Angiostrongylus chabaudi (arrows) on the endothelium of right ventricle a wildcat in Northern Greece
Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens considered an emerging pathogen occurring with high prevalence Mediterranean areas and many parts of tropical Asia. In Hong Kong, second species, Candidatus hongkongensis, has been reported. The present study aimed to compare mitochondrial genomes from these parasites obtain population genetic information.Complete were obtained by PCR Sanger sequencing or ILLUMINA...
We examined extended-spectrum β-lactamase-producing isolates from livestock, humans, companion animals, food, and the environment during 2009-2016 in Germany for presence of CTX-M-27 allele within Escherichia coli sequence type (ST) 131. E. ST131 C1-M27 was exclusively present humans; its incidence increased 0% 2009 to 45% 2016.
To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany.
Abstract Purpose We designed and tested a point of care test panel to detect E.coli antibiotic susceptibility in urine samples from patients at the urological department. The aim this approach is facilitate choosing an appropriate for urinary tract infections (UTI) first presentation context increasing resistance uropathogens worldwide. Methods analyzed 162 isolates university department determine phenotypic genotypic data. With data we created customized LAMP (loop-mediated isothermal...
Abstract Background The use of antibiotic therapy in acute pancreatitis remains controversial and is currently recommended only for confirmed infections peripancreatic necrosis. However, reliable early predictors septic complications unfavorable outcomes are substantially lacking. Methods Patients with were retrospectively reviewed divided into two groups: one a course defined by pathogen detection [GERM(+)] without [GERM(-)]. After propensity score matching, both groups compared regarding...
Proteus mirabilis is a well-known opportunistic pathogen predominantly associated with urinary tract infections. It exhibits natural resistance to multiple antibiotics, including last-resort options like colistin. The emergence and spread of multidrug-resistant P. isolates, those producing ESBLs, AmpC cephalosporinases, carbapenemases, are now more frequently reported. most common carbapenemase types found in KPC-2, IMP, VIM, NDM, OXA-48. We sequenced the genomes three carbapenem-resistant...
Whole-genome sequencing analysis of Vancomycin-resistant Enterococcus faecium isolates from the Frankfurt metropolitan region revealed that 78/94 were MLST type ST117, cgMLST complex CT71 with a common vanB chromosomal insertion site. This indicates circulation single VRE clone in catchment area 5,000-km2 3 million inhabitants.
ABSTRACT Here, we report the complete and annotated genome sequence of probiotic Enterococcus faecalis Symbioflor 1 clone DSM 16431, included in a commercial product used for more than 50 years without any reports infection. This will provide new insights into biology this nonpathogenic microorganism.
To analyse the rectal carriage rate and molecular epidemiology of vancomycin-resistant Enterococcus faecium (VREfm) recovered from patients upon hospital admission.Adult were screened at six German university hospitals five different federal states admission for colonization with VREfm between 2014 2018. Molecular characterization was performed by WGS followed MLST core-genome analysis.Of 16350 recruited, 263 colonized VREfm, increasing prevalence rates during 5 year study period (from 0.8%...
Multi-drug resistant Klebsiella pneumoniae strains are a common cause of health care associated infections worldwide. Clonal spread isolates carrying plasmid mediated CTX-M-15 have been commonly reported. Limited data is available regarding dissemination chromosomally encoded in worldwide.We examined 23 non-repetitive ESBL-producing isolated from clinical specimens over period 4 months German University Hospital. All were characterized to determine their genetic relatedness using...
A nonconjugative and nontypable plasmid of a clinical Escherichia coli isolate expressing resistance to extended-spectrum cephalosporins (ESCs) was isolated sequenced. The pECOH89 contains CTX-M-15 cassette comprises 111,741 bp, with strong homology bacteriophage-like plasmids the Salmonella-specific bacteriophage SSU5.
Strain E19T described as Hartmannibacter diazotrophicus gen. nov. sp. was isolated from the rhizosphere of Plantago winteri a natural salt meadow in nature protection area. is plant growth-promoting rhizobacterium able to colonize barley and promote its growth only under stress conditions. To gain insights into genetic bases promotion lifestyle at salty conditions, we determined complete genome sequence using two complementary sequencing platforms (Ilumina MiSeq PacBio RSII). The comprises...
Abstract Perianal abscesses are frequent diseases in general surgery. Principles of standard patient care surgical drainage with exploration and concomitant treatment fistula. Antiinfective therapy is frequently applied cases severe local disease perianal sepsis. However, the role microbiologic testing purulence from disputed knowledge concerning bacteriology bacterial resistances very limited. A retrospective cohort study was performed consecutive patients (≥ 12 years age) a tertiary...