A5037801579- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Animal Behavior and Welfare Studies
- Insect-Plant Interactions and Control
- Prostate Cancer Treatment and Research
- Angiogenesis and VEGF in Cancer
- Meat and Animal Product Quality
- Infectious Diseases and Mycology
- Cancer, Stress, Anesthesia, and Immune Response
- Effects of Environmental Stressors on Livestock
- Phytoestrogen effects and research
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Fatty Acid Research and Health
- Agricultural pest management studies
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Stress Responses and Cortisol
- HER2/EGFR in Cancer Research
- Insect and Pesticide Research
- Birth, Development, and Health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Agronomic Practices and Intercropping Systems
- Lung Cancer Diagnosis and Treatment
Universidad Complutense de Madrid
2016-2025
Hospital San Pedro de Alcántara
2018-2024
SUNY Downstate Health Sciences University
2024
Revista Conamed
2022
Complejo Hospitalario de Cáceres
2021
Fundación Santa Fe de Bogotá
2021
University of Michigan–Ann Arbor
2018-2020
MD Anderson Cancer Center Madrid
2017
National University of Jujuy
2014
AmeriCorps
2013
Angiostrongylus chabaudi (arrows) on the endothelium of right ventricle a wildcat in Northern Greece
Mounting evidence suggests that malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) are valuable biomarkers of lipid nucleic acid oxidation in numerous canine diseases. However, their application clinical settings is limited due to the absence reference intervals (RI) analytical inconsistencies. Therefore, this study aimed characterize serum MDA 8-OHdG concentrations dogs, establish assay-specific RI, identify biological, haematological biochemical factors influencing these...
Abstract A phylogeographic analysis inferred from the partial mitochondrial cytochrome oxidase subunit I gene (433 bp) was performed with 22 populations of Diaphorina citri Kuwayama collected in Americas and one Pacific. Eight four countries South America, 14 North Hawaii were analyzed. Twenty-three haplotypes (hp) identified they fell into two groups: hp1–8 America (group 1) hp9–23 2). Hp1 nine present highest frequencies within each population their group, 81 85% for group 1 2,...
Canine inflammatory mammary cancer (IMC) shares epidemiologic, histopathological and clinical characteristics with the disease in humans has been proposed as a natural model for human breast (IBC). The aim of this study was to characterize new cell line from IMC (IPC-366) comparative both IBC. Tumors cells female dog were collected. grown under adherent conditions. growth, cytological, ultrastructural immunohistochemical (IHC) IPC-366 evaluated. Ten Balb/SCID mice inoculated assess their...
Abstract Identifying better predictive and prognostic biomarkers for the diagnosis treatment of triple negative breast cancer (TNBC) is complicated by tumor heterogeneity ranging from responses to therapy, mutational burden, clonal evolution. To overcome gap in our understanding heterogeneity, we hypothesized that isolating studying gene expression profile invasive cell subpopulations would be a crucial step towards achieving this goal. In report, utilized fluidic device previously reported...
Journal Article Biology and Life Tables of Galendromus helveolus (Acari: Phytoseiidae) on Florida Citrus Get access Sara Caceres, Caceres 1 University Florida, Institute Food Agricultural Sciences, Research Education Center, Lake Alfred, 33850 Instituto Nacional de Tecnologia Agropecuaria (INTA) C.C. 5 (3432) Bella Vista, Corrientes (Argentina). Search for other works by this author on: Oxford Academic PubMed Google Scholar Carl C. Childers Environmental Entomology, Volume 20, Issue 1,...
Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that naturally present in diet. There are no previous studies on its effects human inflammatory breast cancer or canine mammary the most aggressive type of cancer.The aim this study was to analyze effect indole-3-carbinol SCID mice xenograft model cancer, using equivalent oral dose as therapy humans for 3 weeks.Indole-3-carbinol treatment decreased tumor proliferation and...
Salivary samples were collected over a 24-hr period from one group of six juvenile (7-12 years) and three adult (24-25 African elephant females, Loxodonta africana, the cortisol concentration was measured in unextracted by EIA. Samples during May, June, November 2012 (n = 147) using cotton swabs at 4-hr intervals 20:00 to next day (seven per animal each trial). The animals are kept under standard zoo management: herd is maintained their indoor enclosures until 10:00 then released into...
Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human breast (IBC) has been proposed as a good model for studying the disease. The aim of this study was to evaluate capacity female male mice reproduce IMC IBC tumors identify hormonal tumor environment. To perform sixty 6–8-week-old were inoculated subcutaneously suspension 10 6 IPC-366 SUM149 cells. Tumors serum collected used analysis. Results revealed that reproduced in 90% males after 2...
The consumption of isoflavones is gaining popularity worldwide due to their beneficial effects on health. However, are considered be endocrine disruptors and cause deleterious hormone-sensitive organs, especially in males. Therefore, this study aimed determine if a continuous prolonged exposure adult males altered the axis effect testicular function. For purpose, seventy-five male rats were administered with low high mixtures (genistein daidzein) for 5 months. determination steroid hormones...
Monitoring ovarian cycles through hormonal analysis is important in order to improve breeding management of captive elephants, and non-invasive collection techniques are particularly interesting for this purpose. However, there some practical difficulties collecting proper samples, easier more methods may be an advantage institutions and/or animals. This study describes the development validation enzymeimmunoassay (EIA) progestins salivary samples African Loxodonta africana. Weekly urinary...
Isoflavones are the most common phytoestrogens found in human diets. However, it is still not clear whether isoflavones have effects on reproductive and endocrine systems under normal dietary intake overdose. The aim of this study was to determine how important isoflavones, genistein daidzein, affect androgen glucorticoid levels male prepuberal rats. A hundred seventy-five 30-day-old Wistar rats were dosed orally by stomach tube every day for 35 days, with saline solution, low high doses...
The triple-negative breast cancer (TNBC) subtype is characterized by the lack of expression ERα (estrogen receptor α), PR (progesterone receptor) and no overexpression HER-2. However, TNBC can express androgen (AR) or estrogen β (ERβ). Also, secretes steroid hormones influenced hormonal fluctuations, so inhibition could exert a beneficial effect in treatment. aim this study was to evaluate dutasteride, anastrozole ASP9521 vitro processes using human cell lines. For this, immunofluorescence,...
Abstract Background Total antioxidant status (TAS) is one of the most widely used oxidative stress biomarkers, but lack canine RI and influence analytical factors hinder its application in clinical practice. Objectives The aims this study were to establish assay‐specific for TAS evaluate sources biological variation association between multiple hematologic biochemical variables. Methods Blood samples from 190 clinically healthy dogs collected, encompassing pet (82), police (56), shelter...
This study was performed to determine how two of the most important isoflavones, genistein and daidzein, affect gonadal axis in male prepuberal rats. One hundred seventy-five Wistar rats were allocated into seven groups: one control group six experimental groups that orally administered a high or low dose genistein, daidzein mixture both. Testosterone determination assayed by EIA. The testes body weights measured, histology epididymis with sperm content epididymal count evaluated. In group,...
Abstract Inflammatory breast carcinoma (IBC) is a special type of cancer with poor survival rate. Though several IBC cell lines have been established, recently first IMC line was established. The aims this study were: (1) to validate highly sensitive, reliable, accurate and direct amplified enzyme immunoassay (EIA) measure cell-secreted steroid hormones: progesterone (P4), androstenedione (A4), testosterone (T), 17β-estradiol (E2) estrone sulfate (SO4E1) in the culture medium. (2) To assess...
Human inflammatory breast cancer (IBC) and canine mammary (IMC) are the most lethal cancers. An exacerbated angiogenesis existence of vasculogenic mimicry (VM) hallmarks these tumors. The information regarding VM ultrastructural characteristics cell lines is scant.In this study, IBC line SUM149 IMC IPC-366 in adherent (2D) non-adherent (3D) (mammospheres, stem cells) conditions were analyzed by transmission scanning electron microscopy (TEM SEM, respectively).The TEM revealed round to oval...
Contents Canine inflammatory mammary cancer ( IMC ) has been proposed as a model for the study of human breast IBC ). The aims this were to compare immunohistochemical expression aromatase (Arom) and several hormone receptors [estrogen receptor α ER ), estrogen β progesterone PR androgen AR )], in 21 cases vs 19 non‐ ; possible effect letrozole on canine vitro using IPC ‐366 SUM ‐149 cell lines. Significant elevations means Arom Total Score TS found group (p = 0.025, p 0.038 0.037,...
Inflammatory breast cancer (IBC) is an aggressive type of with poor survival in women. mammary (IMC) dogs very similar to human IBC and it has been proposed as a good surrogate model for study the disease. The aim was determine if IPC-366 shared characteristics cell line SUM149. comparison conducted terms ability grow (adherent nonadherent conditions), stem markers expression using flow cytometry, protein production western blot tumorigenic capacity. Our results revealed that both are...
Certain events can cause distress in cattle. In Spain, there is a sport similar to rodeo called persecution and takedown, which calves are harassed knocked down by riders. this study, the physiological stress response of (n = 260) assessed measuring hormonal parameters. Salivary samples were collected from Salers 110) Lidia 150) before, during, after takedown event. The hormones epinephrine, cortisol, serotonin, dopamine determined saliva using enzyme-immunoassay techniques. results obtained...
The aim was to study the effects of flutamide on cell proliferation, in vivo tumour growth and steroid production canine human IBC lines. IPC ‐366 SUM149 cultures were exposed concentrations for 72 hours. Additionally, xenotransplanted mice treated subcutaneously with 3 times a week 2 weeks. Steroid hormones determination culture media, serum homogenates (pregnenolone, progesterone, androstenedione, testosterone, dihydrotestosterone, 17β‐oestradiol oestrone sulphate) assayed by EIA . vitro...
The validity of spontaneous canine mammary cancer (CMC) as a natural model for the study human breast (HBC) from hormonal point view has never been thoroughly investigated. In this study, we analyzed immunohistochemical expression aromatase (Arom) and steroid receptors [estrogen receptor α (ER α), estrogen β β), progesterone (PR) androgen (AR)] intratumor hormone levels 17β-estradiol (E2), estrone sulfate (SO4E1), (P4), androstenedione (A4), dehydroepiandrosterone (DHEA), testosterone (T) in...