A5018576572- Appendicitis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Diverticular Disease and Complications
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Abdominal Surgery and Complications
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- COVID-19 and healthcare impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Donation and Transplantation
- Natural product bioactivities and synthesis
- Bacterial Infections and Vaccines
- Infant Nutrition and Health
University of Giessen
2019-2024
Universitätsklinikum Gießen und Marburg
2018-2023
Universitätskinderklinik
1993-2021
Goethe University Frankfurt
2011-2020
Frankfurt Cancer Institute
2015-2020
Heidelberg University
2015-2020
German Cancer Research Center
2015-2020
Deutschen Konsortium für Translationale Krebsforschung
2015-2020
Universitäts-Kinderklinik Würzburg
2010-2020
GTx (United States)
2019
Abstract Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV) replication. Here, we investigated the influence of restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV We demonstrated that silencing SAMHD1 in hepatic cells increased replication, while overexpression had opposite effect. significantly affected levels extracellular viral DNA as well intracellular reverse transcription products, without affecting RNAs or cccDNA. mutations...
Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium ROS cells found be crucial for survival, thus increased levels may trigger ferroptosis HCC. In our study, we investigated the effect different modulators inducers human HCC line hepatoblastoma...
Hepatitis B virus (HBV) chronic infection is a critical risk factor for hepatocellular carcinoma. The innate immune response to HBV matter of debate. In particular, viral escape mechanisms are poorly understood. Our study reveals that RNAs not immunostimulatory in immunocompetent myeloid cells. contrast, DNA from particles and replication intermediates sensed by cyclic GMP-AMP Synthase (cGAS) Stimulator Interferon Genes (STING). We show primary human hepatocytes express sensors reduced...
The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, strong negative impact on (ES) had been described already early in situation. However, knowledge limited about current effects of patient flow through rooms, daily routine decision making ES as well their changes over time during last two years. This second survey investigates course pandemic.A web distributed to medical specialists four-week...
Morgagni-Larrey congenital diaphragmatic hernia (MLH) is rare in adult patients and surgery performed infrequently. The evidence regarding the most beneficial treatment modality low. Nevertheless, with increasing experience minimally-invasive surgery, literature proves laparoscopic approach as being safely feasible. However, knowledge on disease well options are based single surgeon's experiences small case series literature.Retrospective single-center analysis (≥ 18 years) MLH from 01/2003...
Hepatocellular carcinoma (HCC) is the most common liver malignancy, and lack of effective chemotherapies underlines need for novel therapeutic approaches this disease. Recently, we discovered a synergistic induction cell death by combining sorafenib, only routinely used palliative chemotherapeutic agent, triterpenoid oleanolic acid (OA). However, underlying mechanisms action have remained obscure. Here, report that sorafenib OA acted in concert to trigger mitochondria-mediated apoptotic...
Abstract Purpose Acute appendicitis in the elderly is becoming increasingly recognized for its often severe course. For various elective and urgent operations older patients, frailty a risk factor poor outcomes. However, there lack of data on patients with acute appendicitis. Methods Patients over 65 years old who underwent surgery three hospitals between January 2015 September 2020 were assessed Hospital Frailty Risk Score (HFRS) modified Index (mFI). Outcomes interest, including morbidity,...
Abstract Perianal abscesses are frequent diseases in general surgery. Principles of standard patient care surgical drainage with exploration and concomitant treatment fistula. Antiinfective therapy is frequently applied cases severe local disease perianal sepsis. However, the role microbiologic testing purulence from disputed knowledge concerning bacteriology bacterial resistances very limited. A retrospective cohort study was performed consecutive patients (≥ 12 years age) a tertiary...
Abstract Purpose The association between sarcopenia of kidney transplant recipients and outcome after transplantation (KT) has not yet been fully understood is still considered controversial. aim our study was to analyze the impact pre-transplant on graft function, postoperative complication rates, survival patients renal transplantation. Methods In this retrospective single-center study, all who underwent KT (01/2013–12/2017) were included. Demographic data, rejection delayed patient rates...
Background and aims CD 15 is expressed by various cancer types; among these are intrahepatic perihilar cholangiocarcinoma ( CCA ). The aim of this study was to elucidate expression in distal as well dysplastic biliary tissue determine its prognostic significance. Methods results Tissue samples from patients with iCCA , n = 22), pCCA 7) dCCA 15), who underwent surgical resection the period 2010 2015 were evaluated for expression. synchronous lymph node metastasis 13), ‐associated dysplasia...