A5007005948- Colorectal and Anal Carcinomas
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Inflammatory Myopathies and Dermatomyositis
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pediatric Hepatobiliary Diseases and Treatments
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Genetic factors in colorectal cancer
- Macrophage Migration Inhibitory Factor
- Mast cells and histamine
University Hospital Frankfurt
2016-2025
Goethe University Frankfurt
2016-2025
Senckenberg Research Institute and Natural History Museum Frankfurt/M
2017-2019
Princess Margaret Cancer Centre
2018
Arizona State University
2004
University of Minnesota Rochester
1981
Mayo Clinic
1976
The macrophage migration inhibitory factor (MIF) receptor CD74 is overexpressed in various neoplasms, mainly hematologic tumors, and currently investigated clinical studies. quickly internalized recycles after antibody binding, therefore it constitutes an attractive target for antibody-based treatment strategies. has been further described as one of the most up-regulated molecules human glioblastomas. To assess potential relevance anti-CD74 treatment, we determined cellular source...
Immune-modulating therapy is a promising for patients with cholangiocarcinoma (CCA). Microsatellite instability (MSI) might be favorable predictor treatment response, but comprehensive data on the prevalence of MSI in CCA are missing. The aim current study was to determine German tertiary care hospital. Formalin-fixed paraffin-embedded tissue samples, obtained period from 2007 2015 undergoing surgical resection curative intention at Johann Wolfgang Goethe University hospital, were examined....
Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized testing better mechanistic understanding the main HNC drivers. Here, we have established comprehensive molecularly functionally characterized head organoid biobank (HNOB) recapitulating clinically relevant subtypes TP53 mutant human papillomavirus type 16 (HPV 16) infection-driven HNC....
Benzene is a well documented carcinogen for the hematic and lymphopoietic system, experimental research confirms its carcinogenicity tumors of other sites. This report presents results historical cohort study in shoe manufacturing plant Florence where cases aplastic anemia leukemia were reported 1960s. A total 1008 men 1005 women considered eligible members cohort. For mortality, comparing rates with national rates, standardized mortality ratio (SMR) was 79 95 men. excesses risk [SMR 1566;...
Searching for chemical agents and molecular targets protecting against secondary neuronal damage reflects one major issue in neuroscience. Cannabinoids limit neurodegeneration by activation of G protein‐coupled cannabinoid receptor 1 (CB ) microglial 2 ). However, pharmacological experiments with CB /CB ‐deficient mice unraveled the existence further, so‐called non‐CB /non‐CB (GPR) subtypes. GPR55, whose function brain is still poorly understood, represents a novel target various...
The metabolic properties of lymphomas derived from germinal center (GC) B cells have important implications for therapeutic strategies. In this study, we compared features Hodgkin–Reed–Sternberg (HRS) cells, the tumor classical Hodgkin's lymphoma (cHL), one most frequent (post-)GC-derived B-cell lymphomas, with their normal GC cell counterparts. We found that ratio oxidative to nonoxidative energy conversion was clearly shifted toward phosphorylation (OXPHOS)-linked ATP synthesis in HRS as...
Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim this study was to characterize genetic 5 patients with SI-NETs. Therefore, formalin-fixed, paraffin-embedded tissue samples primary metastatic lesions as well benign five synchronously metastasized, differentiated SI-NETs were analyzed whole exome sequencing. For one patient, chip based 850k DNA methylome analysis performed tumor control tissue. Thereby, 156...
// Dirk Walter 1, 2 , Claudia Döring Magdalena Feldhahn 3 Florian Battke Sylvia Hartmann Ria Winkelmann Markus Schneider Katrin Bankov 1 Andreas Schnitzbauer 4 Stefan Zeuzem Martin Leo Hansmann Jan Peveling-Oberhag 2, 5 Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, 60590 Frankfurt, Germany Dr. Senckenberg Institute Pathology, CeGaT GmbH, 72076 Tuebingen, General and Visceral Surgery, for Gastroenterology, Hepatology Endocrinology, Robert-Bosch 70376...
Peripheral blood leukocytosis has been implicated in promoting tumor progression leading to worse survival, but the mechanisms behind this phenomenon remain unexplored. Here, we examined prognostic role of pretreatment white cell (WBC) count and clinicopathologic parameters context CD8+ tumor-infiltrating lymphocytes (TIL) myeloperoxidase+ tumor-associated neutrophils (TANs) patients with anal squamous carcinoma (ASCC) treated definitive chemoradiotherapy (CRT). After a median follow-up 26...
Establishing the etiology of invasive fungal infections is important to guide therapeutic options and for epidemiologic purposes. Formalin-fixed, paraffin-embedded (FFPE) tissue specimens from patients with proven are valuable determine systemic infections. We compared different polymerase chain reaction (PCR) amplification strategies FFPE blocks identify agents found that specific PCR assays show superior sensitivity in identification DNA Mucorales Aspergillus mixed caused by both as...
Background: Definitive chemoradiotherapy (CRT) is the primary treatment for non-metastatic anal squamous cell carcinoma (ASCC). Despite favorable outcomes in general, failure rates up to 40% occur locally advanced disease. For escalation or de-escalation strategies easily assessable and valid biomarkers are needed. Methods: We identified 125 patients with ASCC treated standard CRT at our department. C-reactive protein (CRP) albumin ratio (CAR) was calculated dividing baseline CRP by levels....
Aim of the study was to evaluate prognostic impact CD8-positive (CD8+) tumour-infiltrating lymphocytes (TILs) and PD-L1 expression on outcome patients with malignant salivary gland neoplasms. Formalin-fixed, paraffin-embedded tissue samples clinicopathological data from treated for carcinoma in a head neck cancer centre were retrospectively retrieved. Immunohistochemical staining applied sections 84 specimens 12 different histological subtypes. Both CD8 rated by semi-automated cell counts...
Abstract Background Treatment plans for squamous cell carcinoma of the head and neck (SCCHN) are individually decided in tumor board meetings but some treatment decision-steps lack objective prognostic estimates. Our purpose was to explore potential radiomics SCCHN therapy-specific survival prognostication increase models’ interpretability by ranking features based on their predictive importance. Methods We included 157 patients (male, 119; female, 38; mean age, 64.39 ± 10.71 years) with...
Introduction: Merkel cell carcinoma (MCC) is linked to the presence of clonally integrated polyomavirus (MCPyV) in up 80% cases. The aim study was determine prognostic value baseline MCPyV viral load and lymphocytic infiltration. Methods: DNA prevalence, integration status were determined by specific quantitative real-time PCR surgical specimens obtained from 49 patients with MCC treated (n = 22, 45%) or without postoperative radiotherapy (RT). CD8+ tumor infiltrating lymphocytes (TILs)...
5 of 6 adults with generalized granuloma annulare responded favorably to therapy low-dose chlorambucil. the patients had lesions that were recurrent and long-standing resisted conventional modalities therapy. Low-dose chlorambucil may be effective in a short-term program but should used only persistent, widespread, or unusual forms annulare. The requires close patient hematologic supervision.
Penile carcinomas are rare tumors throughout Europe. Therefore, little attention is drawn to this disease. That makes it important study tumor-associated key metrics and relate these known data on penile neoplasias.A cohort of 60 well-defined invasive with human papillomavirus (HPV) infection status was investigated. Data tumor type, grading staging were recorded. Additionally, the peri- intratumoral immune cell infiltrate in a semiquanititave manner applying an HE stain assessed.Our showed...
Abstract Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced stages. Therefore, understanding biology and its microenvironment correlation with known survival data is of substantial interest order to establish treatment strategies adapted the individual patient. Fifty-five therapy naïve carcinomas, age range between 41 85 years clinicopathological data, were investigated use tissue...
Background: Definite diagnosis and therapeutic management of cholangiocarcinoma (CCA) remains a challenge. The aim the current study was to investigate feasibility potential impact on clinical targeted sequencing intraductal biopsies. Methods: Intraductal biopsies with suspicious findings from 16 patients CCA in later course were analyzed including tumor control benign tissue (n = 55 samples). A CCA-specific panel containing 41 genes designed dual strand enrichment applied. Results:...
Background and aims CD 15 is expressed by various cancer types; among these are intrahepatic perihilar cholangiocarcinoma ( CCA ). The aim of this study was to elucidate expression in distal as well dysplastic biliary tissue determine its prognostic significance. Methods results Tissue samples from patients with iCCA , n = 22), pCCA 7) dCCA 15), who underwent surgical resection the period 2010 2015 were evaluated for expression. synchronous lymph node metastasis 13), ‐associated dysplasia...