A5031606937- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Radiation Therapy and Dosimetry
- Radiation Effects in Electronics
- Head and Neck Surgical Oncology
- Electromagnetic Fields and Biological Effects
- Reconstructive Surgery and Microvascular Techniques
- Facial Trauma and Fracture Management
- Laser Applications in Dentistry and Medicine
- Head and Neck Cancer Studies
- Cardiac Ischemia and Reperfusion
- Dental materials and restorations
- Oral and Maxillofacial Pathology
- Wound Healing and Treatments
- Spaceflight effects on biology
- Mitochondrial Function and Pathology
- Dermatologic Treatments and Research
- Reconstructive Facial Surgery Techniques
- Ultrasound and Hyperthermia Applications
- Biofield Effects and Biophysics
- Dental Research and COVID-19
- bioluminescence and chemiluminescence research
- Dental Trauma and Treatments
- Wireless Body Area Networks
- Cardiovascular Effects of Exercise
Goethe University Frankfurt
2022-2025
University Hospital Frankfurt
2022-2024
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2023
Goethe Institute
2023
National Medical Research Center of Dentistry and Maxillofacial Surgery
2020
GSI Helmholtz Centre for Heavy Ion Research
2017-2018
Technical University of Darmstadt
2011-2018
Aschaffenburg University of Applied Sciences
2018
Darmstadt University of Applied Sciences
2013
The alveolar ridge undergoes a loss in volume and atrophy after tooth extraction. Understanding the wound healing bone regeneration process extraction is key factor insertion of dental implants. Therefore, aim present study was to analyze socket upper premolars based on cone beam computed tomography (CBCT) over six months. Special focus placed morphological changes crest within socket. A retrospective analysis patients need premolar region performed this study. All received flapless under...
After tooth extraction, resorptive changes in extraction sockets and the adjacent alveolar ridge can affect subsequent replacement implantation. Several surgical concepts, including application of autologous blood concentrate platelet-rich fibrin (PRF), aim to reduce these changes. While PRF’s wound-healing pain-relieving effects are well-documented, its impact on bone regeneration is less clear due varying PRF protocols measurement methods for regeneration. This study aimed develop a...
Multicellular spheroids represent a well-established 3D model to study healthy and diseased cells in vitro. The use of conventional cell culture platforms for the generation multicellular is limited types that easily self-assemble into because less adhesive fail form stable aggregates. A high-precision micromoulding technique developed our laboratory produces deep conical agarose microwell arrays allow cultivation uniform aggregates, irrespective spheroid formation capacity cells. Such...
Childhood trauma defects in the head and neck area are challenging many aspects for patients surgeons. One major issue is still incomplete growth. Bone defect fixation measures have to consider biomechanical forces due bone growth from both sides, possibly influencing working against itself vice versa. A solution will be development of a stable but, at same time, quickly degradable osteosynthesis system (OSS) specifically pediatric sector. Besides physical demands, biocompatibility low risk...
Following tooth extraction, the bone structure is prone to atrophic changes. Alveolar ridge resorption can compromise subsequent implant treatment not only at extraction site itself but also by affecting support of adjacent teeth. Various techniques, including use graft materials or autologous blood concentrates for socket preservation, aim counteract this process. The efficacy such methods be evaluated non-invasively through radiological analysis treated region. However, existing evaluation...
Despite advances in treatment, recurrence rates oral squamous cell carcinoma (OSCC) remain high. Prognostic outcomes vary terms of local recurrence, metastasis, and overall survival. A retrospective cohort analysis was conducted on OSCC patients who underwent primary surgery at the Department Craniomaxillofacial Facial Plastic Surgery, University Medical Center Frankfurt, between January 2014 December 2020. Demographic data, tumor characteristics, surgical details, intraoperative frozen...
This study aimed to compare the effectiveness of platelet-rich fibrin clot (PRF) and conventional oroantral communication (OAC) repair techniques following tooth extractions from maxilla. The involved 22 patients, divided into 2 groups: a group treated with PRF control undergoing OAC repair. primary outcome measured was closure, pain intensity postoperative complications as secondary outcomes. Cone-beam computed tomography (CBCT) used evaluate post-extraction bone regeneration. Pain assessed...
Exposure to radiofrequency (RF) electromagnetic fields (EMF) is continuously increasing worldwide. Yet, conflicting results of a possible genotoxic effect RF EMF continue be discussed. In the present study, (GSM, 1,800 MHz) in human lymphocytes was investigated by collaboration six independent institutes (institutes a, b, c, d, e, h). Peripheral blood 20 healthy, nonsmoking volunteers two age groups (10 16–20 years old and 10 50–65 old) taken, stimulated intermittently exposed three specific...
Introduction The aim of the study was to evaluate accuracy MRI and CT with regard detection lymph node metastases based on data specific patients OSCC who received bilateral neck dissection. Materials methods In a retrospective analysis from 01/2014 12/2020 underwent primary tumor resection dissection were evaluated. Results 174 preoperative (78.74%, N=137) (21.26%, N=37) correlated histopathological findings. had sensitivity 67% specificity 68% (p=0.76). showed an overall 66% 52.87% all...
Systematic evaluations regarding the influence of PRF in ridge sealing are still lacking. To best our knowledge, this is first systemic randomized, controlled, clinical approach dealing with potential a systematic applied solid on soft tissue socket healing molar and premolar extraction sockets evaluation for up to 90 days. Qualitative quantitative image analysis showed that contributed significantly faster sealing, within period 7–10 days both tooth types. This led visibly less contraction...
Near infrared (NIR) and X-rays are radiations from different sides of the wavelength spectrum but both used during medical treatments, as they have severe impacts on cellular processes, including metabolism, gene expression, proliferation survival. However, differ strictly in their consequences for exposed patients: NIR effects generally supposed to be positive, mostly ascribed a stimulation whereas X-ray leads genetic instability, an increase reactive oxygen species (ROS) DNA damages...
Introduction: E-Scooters are trending as an individual transport vehicle with electric drive in Germany. But there is less data about the frequency, demographic details and possible injuries therapy needs context E-scooter accidents. Therefore, primary aim of this study was to analyze frequency characteristics facial trauma well consecutive hospitalization management after E-scooters a German clinic specialized craniomaxillofacial surgery. Materials Methods: Retrospective analysis hospital...
Treatment of extended defects after tumor resection in oral, maxillofacial, and facial surgery (craniomaxillofacial) is usually performed by free microvascular flaps. Evaluation flap survival crucial, especially the first hours insertion connection. For evaluation various invasive noninvasive methods have been developed. This retrospective clinical study examined ability a hyperspectral imaging (HSI) camera (Tivita, Diaspective Vision, Germany) to assess postoperative properties comparison...
Benefit of concomitant infrared hyperthermia and low level laser therapy ionizing radiation is evaluated in this study. The purpose/objectives: presentation with locally advanced bulky superficial tumors clinically challenging. To enhance the efficacy chemotherapy IMRT (intensity-modulated therapy) and/or electron beam we have developed an inexpensive effective approach that combines black-body halogen spectrum discrete wave length clinical lasers LLLT. goal to produce a composite extending...
Oral cancer is a common and life threatening disease that requires interdisciplinary treatment often necessitates complex facial reconstruction. Standard care includes tumor resection, while reconstruction routinely performed with free radial forearm flaps. As esthetic results are crucial for quality of life, flap size, volume, composition have to be considered. To date no standardized measurement volume shrinkage has been established routine use. The purpose this study was therefore...
This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histology. Combinations "sticky bone" and tenting screws without autologous bone were used as augmentative materials.
Tumor resection combined with neck dissection (ND) or radiotherapy are established methods for the treatment of patients oral squamous cell carcinoma (OSCC). However, extent ND can lead to postoperative complications. Therefore, first time, this study aims identify lymph node involvement in OSCC performed a bilateral systematic approach based on oncologic board meetings relying presurgical magnetic resonance imaging (MRI) and computed tomography (CT).In retrospective single-center study,...
Since essentially no information is available on the effects of high linear energy transfer (LET) radiation heart, an assessment possible late cardiovascular system important with respect to planning manned long-term space missions [ 1, 2]. In order examine if and what extent heart muscle cells are affected by exposure heavy ions, primary avian cardiomyocytes were isolated, cultured in vitro exposed at GSI (Darmstadt) different ion species (carbon, titanium nickel). Investigation...