A5082142730- Periodontal Regeneration and Treatments
- Veterinary Oncology Research
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Therapeutic Uses of Natural Elements
- Eicosanoids and Hypertension Pharmacology
- Dental Implant Techniques and Outcomes
- Laser Applications in Dentistry and Medicine
- Myofascial pain diagnosis and treatment
- Facial Trauma and Fracture Management
- Fatty Acid Research and Health
- Medical and Biological Ozone Research
- Advanced Glycation End Products research
- Hemostasis and retained surgical items
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Infectious Diseases and Mycology
- Total Knee Arthroplasty Outcomes
- HIV/AIDS oral health manifestations
- Cancer-related Molecular Pathways
- Surgical Sutures and Adhesives
- Osteomyelitis and Bone Disorders Research
- Vagus Nerve Stimulation Research
Iuliu Hațieganu University of Medicine and Pharmacy
2023-2025
Academy of Romanian Scientists
2024
Victor (Japan)
2023
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2022
Mucoadhesive films loaded with doxycycline hyclate (Doxy Hyc), consisting of mixtures hydroxypropylmethyl cellulose (HPMC) E3, K4 and polyacrylic acid (Carbopol 940), were prepared by casting method, aiming to design a formulation intended for application in the oral cavity. The obtained film formulations exhibited Doxy Hyc content between 7.52 ± 0.42 7.83 0.41%, which had adequate mechanical properties cavity pH values tolerance range. x-ray diffraction studies highlighted amorphisation...
Diabetes mellitus is a metabolic disorder associated with oxidative stress, inflammation, and coagulation disturbances, which contribute to microvascular macrovascular complications. We evaluated the therapeutic effects of lavender oil (Lavandula angustifolia) in streptozotocin (STZ)-induced rat model type 1 diabetes (T1DM) experimentally induced thrombosis. Sixty male Wistar rats were divided into control, thrombosis, diabetes, thrombosis–diabetes, pretreatment groups (100 200 mg/kg body...
Grape pomace (GP), the residue left after grape pressing in winemaking, is rich polyphenols, including flavonoids, tannins, and phenolic acids, which have antioxidant anti-inflammatory properties. The present study aimed to evaluate cardioprotective effects of white (WGP) extract two concentrations polyphenols (795 mg from WGP/kg body weight (bw) 397.5 bw)), on isoproterenol (ISO)-induced myocardial infarction (MI), focusing its effects. White administration for 14 days offered a...
In the present study, scaffold composites based on alginate-pullulan-bioactive glass‑gold nanoparticles were orthotopically implanted in an experimental model of delayed bone union, rats, given by a metabolic pathology, namely osteoporosis. Differences between treated and untreated groups observed efficacy our biomaterial was evaluated applying micro-CT imaging, together with histological evaluation osteoporotic animals sub-critical defects, at 30 60 days. Osteoporosis successfully induced...
Childhood trauma defects in the head and neck area are challenging many aspects for patients surgeons. One major issue is still incomplete growth. Bone defect fixation measures have to consider biomechanical forces due bone growth from both sides, possibly influencing working against itself vice versa. A solution will be development of a stable but, at same time, quickly degradable osteosynthesis system (OSS) specifically pediatric sector. Besides physical demands, biocompatibility low risk...
Background: Traumatic injuries cause millions of deaths annually, with intra-abdominal hemorrhage as a leading cause. Achieving hemostasis remains challenging. This study evaluates the hemostatic properties novel biocompatible cyanoacrylate–polylactic acid patch. Methods: Thirty-six male Wistar rats were randomized into three groups (control, study, and TachoSil®) underwent standardized liver resection. The times recorded, blood samples drawn to assess hemoglobin, hematocrit, cytokine levels...
Glucocorticoids are steroid hormones used in clinical practice as an effective therapeutic option for their effects regarding the dysregulated immune reactions and hyperactive system. Their administration short- long-term exposure has been associated with numerous metabolic side effects. Probiotics have shown to modulate basal metabolism, inflammation, oxidative stress through regulation of composition function gut microbial environment. The aim this study was assess Saccharomyces boulardii...
This study investigates the phytochemical composition, anti-inflammatory, antioxidant, and antiproliferative activities of A. absinthium annua flowers leaf ethanol extracts in acute rat inflammation model. Polyphenolic compounds were analyzed quantitatively (total phenolic (TPC) total flavonoids (TFCs)) qualitatively by HPLC-ESI MS analysis. The antioxidant activity was evaluated vitro (by DPPH, FRAP, H2O2, NO scavenging tests), vivo oxidative status (TOS), capacity (TAC), stress index...
Abstract Objective : Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, analog carbamazepine, mild-to-moderate inducer the same isoenzyme. This study aimed evaluate pharmacokinetic interaction between single dose quetiapine multiple doses as pretreatment,...
The immunomodulatory effect of a novel biomaterial obtained through electrospinning, based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP), loaded with doxycycline (doxy) was evaluated in an animal model. treatment capabilities as local non-surgical periodontitis investigated the lower incisors Wistar rats, after induction localized using ligature technique. Following disease, scaling root planing applied, conjunction application new material. results were clinically, tooth...
Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis inflammation are interplayed processes that interact influence one another. Our research compared three routes of administration to assess the efficacy pretreatment with LO on carrageenan-induced thrombosis in rat tail.Wistar-Bratislava white rats were randomly divided into five groups ten each pretreated 3 consecutive days prior...
Abstract Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, current diagnosis often occurs later stages, and there is a pressing need for more comprehensive data on treatment options to improve overall prognosis. Consequently, early detection these critical improving outcomes survival rates. As such, biomarkers essential diagnosis, treatment, prognosis CMT, reason which further research required enhance our understanding disease. The studied CMT...
Myocarditis is a major cause of heart failure and death, particularly in young individuals. Current treatments are mainly symptomatic, but emerging therapies focus on targeting inflammation fibrosis pathways. Natural bioactive compounds like flavonoids phenolic acids show promising anti-inflammatory antioxidant properties. Corticosteroids frequently employed the treatment autoimmune myocarditis appear to lower mortality rates compared conventional for failure. This study aims explore effects...
Antinociceptive, sedative, anti-inflammatory, and antioxidant effects of lavender oil (LO) have been documented. The aim our study was to evaluate the adjuvant pretreatment with LO compared standard treatment (low molecular weight heparin) in thrombosis. We evaluated two doses addition nadroparin calcium (NC) on experimentally induced thrombosis rats. groups were as follows: control (C) group received intraperitoneal (i.p.) saline vehicle (DMSO), (T) plus pretreatment, administrated...
The aim of this research was to validate the use a gentamicin (GEN) and nano-hydroxiapatite (nHAP)-loaded polycaprolactone nanostructured membrane (NM) as an innovative, highly efficient, low-cost treatment for periodontitis. We conducted in vivo study on Wistar rats, which we induced periodontitis by placing silk ligatures around first right left upper molars. subjects were divided into three groups; group received no periodontal treatment, second open flap debridement, third together with...
Introduction. Disorders of peripheral blood circulation affect people all around the world. Balneotherapy, in form carbonated mineral water baths and mofettes, could be considered one treatment options. The current study aims to investigate, an experimental study, effects natural water, with a known composition, mofettes from Băile Tușnad (Romania) on arterial flow. (2) Material method. A total 16 rat subjects were studied, divided equally into 4 groups, evaluated at 2, 6 weeks after...
Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying importance efficient therapeutic findings, besides golden-standard surgery, able to limit development disease. Studies human cancers demonstrated that Doxorubicin presents a good effect different biological processes like apoptosis, autophagy, cell cycle, invasion, and epithelial-to-mesenchymal transition. This study followed effects on two canine cancer lines P114 CMT-U27. treatment both...
Background: The development of new protocols has become a priority today in the context adverse effects conventional treatments. Zeolite falls into this category due to its numerous applications reported specialized literature. In study, main expected objectives were demonstrate that intrauterine administration zeolite can contribute improving indicators underlying pathologies during postpartum period. Methods: To determine dosage and potential toxic on uterine mucosa, we conducted study...
Abstract: (1) Background: The aim of the study was to investigate effecs mofettes and car-bonated mineral water baths on bone healing using a rat femoral defect model; (2) Methods: A 2mm diameter unicortical in left diaphysis 40 Wistar Rats surgically created. Furthermore, subjects were divided into 4 treatment-groups: control, mofette therapy, therapy carbonated bath, bath. At end 2-week treatment at 6 weeks, animals evaluated through Micro-CT analysis histological tissue skin; (3) Results:...
A functional hydrogel containing biopolymer microcarriers loaded with dexamethasone was developed to address the hearing loss that results from cisplatin ototoxicity. The drug delivery platform tested both in vitro HEI-OC1 inner ear cell line and vivo a rat animal model. newly described formula offered prolonged release of contained for up six days transformed into solid state at body temperature, thus counteracting its clearing through Eustachian tube when injected middle ear. When vitro,...
Endometriosis is a common gynecological condition with complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as potential therapeutic agent in reducing size endometriotic lesions and modulate plasma expression MMP-2, MMP-9, TGF-β1. The were induced rat model by autologous transplant endometrium. Thirty-six female rats, Wistar breed, endometriosis, divided into four groups underwent treatment for 28 days. CTRL group received 0.5 mL/day...
Abstract Canine mammary tumors (CMTs) represent a prevalent malignancy in female dogs. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated various cancer types, including CMTs. This study aimed to investigate the altered miRNA patterns CMTs their potential role tumorigenesis. We analyzed profiles cohort CMT samples matched normal tissues using custom canine panel microarray slide (Agilent technology). The bioinformatics analysis overlapped signature...
Background. The use of adipose tissue in reconstructive procedures has become popular the last decades due to properties stem cells and mechanical protection. In acute nerve lesions, there have been experimental reports on non-vascularised as an adjuvant for recovery but our knowledge is no published research that describes effect pedicled vascularised (pVAT) injuries. Therefore we decided study pVAT regeneration when wrapped around epineurial coaptation site a 5 mm defect sciatic from rat....