A5080045546- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Axon Guidance and Neuronal Signaling
- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- Economic and Financial Impacts of Cancer
- Bladder and Urothelial Cancer Treatments
- Endometrial and Cervical Cancer Treatments
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- Ethics in Clinical Research
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- GDF15 and Related Biomarkers
Iuliu Hațieganu University of Medicine and Pharmacy
2018-2024
EMT represents the dominant program within advanced stages of colon cancer, where cells acquire migratory characteristics in order to invade secondary tissues and form metastasis. Where majority therapeutic strategies are concentrated on reduction tumor mass through different apoptotic mechanisms, present study advocates an important role for miR-205-5p impairment cancer migration restoration epithelial phenotype. Upon identification a homogenous downregulated profile adenocarcinoma...
Breast cancer is a highly heterogeneous pathology, exhibiting number of subtypes commonly associated with poor outcome. Due to their high stability, microRNAs are often regarded as non-invasive biomarkers, having an expression pattern specific for 'cell origin'. Triple negative breast (TNBC: ER-, PR-, Her-2-) and double positive (DPBC: ER+, PR+, Her-2) miRNA patterns were obtained by analysis the TCGA (The Cancer Genome Atlas) data, followed PCR-array on plasma samples from 20 TNBC patients,...
Abstract Background Bladder cancer (BC) is a common urothelial malignancy, characterized by high recurrence rate. The biology of bladder complex and needs to be deciphered. latest evidence reveals the critical role non-coding RNAs, particularly microRNAs (miRNAs), as vital regulatory elements in cancer. Method We performed miRNAs microarray using paired tissues (tumor adjacent normal tissue), followed validation with qRT-PCR five selected transcripts. Additional next-generation sequencing...
Prostate cancer biology is complex, and needs to be deciphered. The latest evidence reveals the significant role of non-coding RNAs, particularly microRNAs (miRNAs), as key regulatory factors in cancer. Therefore, identification altered miRNA patterns involved prostate will allow them used for development novel diagnostic prognostic biomarkers.We performed a miRNAs transcriptomic analysis, using microarray (10 matched pairs tumor tissue versus normal adjacent tissue, selected based on...
Smoking is a well-known behavior that has an important negative impact on human health, and considered to be significant factor related the development progression of head neck squamous cell carcinomas (HNSCCs). Use high-dimensional datasets discern novel HNSCC driver genes smoking represents challenge. The Cancer Genome Atlas (TCGA) analysis was performed in three co-existing groups order assess whether gene expression landscape affected by tobacco smoking, having quit, or non-smoking...
Background: Lung cancer remains one of the most diagnosed malignancies, being second cancer, while still leading cause cancer-related deaths. Late diagnosis a problem, alongside high mutational burden encountered in lung cancer. Methods: We assessed genetic profile genes using The Cancer Genome Atlas (TCGA) datasets for mutations and validated results separate cohort 32 patients tumor tissue whole blood samples next-generation sequencing (NGS) experiments. Another was analyzed to validate...
Background: Cervical cancer is one of the most common malignancies in women terms prevalence and mortality. has some particularities that distinguish it from any other oncologic pathology: first, completely preventable by prompt detection its precursor, cervical intraepithelial neoplasia (CIN); second, Human Papillomavirus (HPV) infection a known etiological agent; third, mean age at diagnosis much lower than conditions, as consequence sexually-transmitted HPV. Methods: We evaluated...
Lung cancer remains one of the leading causes cancer-related deaths worldwide. It is classified into two main histological groups: non-small cell lung (NSCLC) and small cancer. Improving outcome patients could be possible by enhancing early diagnosis. In current study, we evaluated levels three microRNAs - miR-21-5p, miR-155-5p, miR-181a-5p in tumor (TT) vs adjacent normal tissue (NT), as well their expression plasma extracellular vesicles (EVs) from squamous carcinoma (LUSC) male healthy...
Background: Non-small cell lung cancer (NSCLC) is still one of the types with highest death rates. MicroRNAs (miRNAs) play essential roles in NSCLC development. This study evaluates miRNA expression patterns and specific mechanisms male patients NSCLC. Methods: We report an integrated microarray analysis miRNAs for eight matched samples males compared to public datasets from TCGA, followed by qRT-PCR validation. Results: For TCGA dataset, we identified 385 overexpressed 75 underexpressed...
The lack of estrogen or progesterone receptors and absence HER2 amplification/overexpression in triple-negative breast cancer (TNBC) restricts therapeutic options used clinical management. MicroRNAs (miRNAs) are small, non-coding transcripts which affect important cellular mechanisms by regulating gene expression at the post-transcriptional level. Among this class, attention was focused on miR-29b-3p with a high profile TNBC correlated overall survival rates, as TCGA data revealed. This...
Abstract Canine mammary tumors (CMTs) represent a prevalent malignancy in female dogs. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated various cancer types, including CMTs. This study aimed to investigate the altered miRNA patterns CMTs their potential role tumorigenesis. We analyzed profiles cohort CMT samples matched normal tissues using custom canine panel microarray slide (Agilent technology). The bioinformatics analysis overlapped signature...
Background and Aims: The world healthcare systems are currently challenged by the accumulating burden of colorectal cancer (CRC), registries represent an important segment for prevention developing management plans, being useful in providing data regarding incidence, mortality, survival, exposure to carcinogens, lifestyle. Retrospective from CRC patients Romania was used assess survival impact, costs, cost-effectiveness considering three crucial aspects: pharmacology, chemo-/radio-therapy,...
MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have emerged as biomarkers for differentiating infection types due to their distinct expression profiles in response pathogens. This study explores miRNA profiling using microarray technology identify signatures differentiate viral from bacterial infections plasma samples.
miRNAs are a class of noncoding RNAs with gene regulation properties, and they function as key factors in cell homeostasis. The interaction their target mRNAs is largely considered to rely on sequence complementarity; however, some evidence indicates that mature can adopt diverse conformations implications for function. Using the oncogenic miR‐181 family study model, we suggest potential relationship between primary secondary structure may have an impact number spectrum targeted cellular...
Clinical application of chemotherapy in lung cancer is constrained by side effects, notably cardiotoxicity, the mechanisms which remain elusive. This study assessed potential specific miRNAs as biomarkers for chemotherapy-induced cardiotoxicity cancer. We employed two adenocarcinoma cell lines (Calu6 and H1792) ventricular normal human cardiac fibroblasts (NHCF-V) single co-culture experiments. Functional tests were conducted using 100 µM carboplatin 1µM vinorelbine doses. The effects...
Background and aims. In the context of novelty personalized medicine biobanking in Romania, there is an acute need to analyze degree knowledge key actors domain. The present study sought investigate understanding ‘biobanking’ ‘personalized medicine’ three categories of
 participants development a biobank – health professionals (clinicians/diagnosticians), scientific researchers, patients, order identify possible faults regarding level information. secondary objective this was elements...