A5040284868- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Neuroblastoma Research and Treatments
- Veterinary Oncology Research
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- Cervical Cancer and HPV Research
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cell Image Analysis Techniques
- Cancer, Lipids, and Metabolism
- Male Breast Health Studies
Institute of Oncology Prof. Dr. Ion Chiricuta
2016-2025
Iuliu Hațieganu University of Medicine and Pharmacy
2014-2022
Cancer Institute (WIA)
2016
The clinical outcome of BC patients receiving the same treatment is known to vary considerably and thus, there a compelling need identify novel biomarkers that can select would benefit most from given therapy predict outcome. aim this study was determine prognostic value CCAT2, long ncRNA recently characterized by our group overlapping SNP rs6983267, in patients. We first evaluated RT-qPCR ISH expression CCAT2 normal breast tissue further analyzed an independent set 997 primary with regard...
EMT represents the dominant program within advanced stages of colon cancer, where cells acquire migratory characteristics in order to invade secondary tissues and form metastasis. Where majority therapeutic strategies are concentrated on reduction tumor mass through different apoptotic mechanisms, present study advocates an important role for miR-205-5p impairment cancer migration restoration epithelial phenotype. Upon identification a homogenous downregulated profile adenocarcinoma...
Abstract: Endometriosis is an inflammatory pathology associated with a negative effect on life quality. Recently, this was connected to ovarian cancer, in particular endometrioid cancer. microRNAs (miRNAs) are class of RNA transcripts ~19–22 nucleotides length, the altered miRNA pattern being pathological status. miRNAs highly stable transcripts, and these can be assessed from formalin-fixed paraffin-embedded (FFPE) samples leading identification that could developed as diagnostic prognostic...
Abstract Background Bladder cancer (BC) is a common urothelial malignancy, characterized by high recurrence rate. The biology of bladder complex and needs to be deciphered. latest evidence reveals the critical role non-coding RNAs, particularly microRNAs (miRNAs), as vital regulatory elements in cancer. Method We performed miRNAs microarray using paired tissues (tumor adjacent normal tissue), followed validation with qRT-PCR five selected transcripts. Additional next-generation sequencing...
Background: Breast cancer (BC) is the most frequently diagnosed in women and leading cause of cancer-related deaths globally. Carriers P/LP variants BRCA1, BRCA2, TP53, PTEN, CDH1, PALB2, STK11 genes have an increased risk developing BC, which why more guidelines recommend prophylactic mastectomy this group patients. Because traditional genetic testing expensive can delays patient management, radiomics based on diagnostic imaging could be alternative. This study aims to evaluate whether...
Advanced squamous cervical cancer, one of the most commonly diagnosed cancers in women, still remains a major problem oncology due to treatment failure and distant metastasis. Antitumor therapy is both intrinsic acquired resistance; resistance often decisive for response. In this study, we investigated specific pathways molecules responsible baseline locally advanced cancer. Twenty-one patients with cell carcinoma were enrolled study. Primary biopsies harvested prior analyzed whole human...
Pancreatic cancer is a devastating disease with mortality rate almost identical its incidence. In this context, the investigation of pancreatic proteome has gained considerable attention because profiles proteins may be able to identify states and progression more accurately. Therefore, our objective was investigate changes in patients suffering from ductal adenocarcinoma ( PDAC ) by comprehensive quantitative approach. Comparative proteomic profiling label‐free LC ‐ MS / analysis nine...
This study was targeted on a metabolomic approach to compare the blood serum free amino acid profiles and concentration of confirmed breast cancer (stages I-III) patients healthy controls in order establish reliable biomarkers early detection prediction cancer. The ultra-high-performance liquid chromatography coupled with mass spectrometry using positive ionization electrospray applied for picoline-derivatized acids EZ:faastTM kit. Multivariate statistical analysis principal component...
MicroRNAs (miRNAs), a class of small non-coding RNAs represent potential biomarkers for colorectal cancer (CRC). The study hypothesized that miRNAs associated with liver metastases may also contribute to assessing treatment response when plasma exosomes. In this study, we used two sets biological samples, collection tumor tissues harvested from patients CRC and without metastases, FOLFOX4/FOLFIRI regimens. We investigated 10 target in the tissue 28 identified miR-125b-5p, miR-17-5p,...
Background and Objectives: To assess ovarian cysts with texture analysis (TA) in magnetic resonance (MRI) images for establishing a differentiation criterion endometriomas functional hemorrhagic (HCs) that could potentially outperform their classic MRI diagnostic features. Materials Methods: Forty-three patients known who underwent were retrospectively included (endometriomas, n = 29; HCs, 14). TA was performed using dedicated software based on T2-weighted images, by incorporating the whole...
Circulating tumor cells (CTCs) are nowadays one of the most promising biomarkers. It is well correlated with overall survival and progression-free in breast cancer, as many other types human cancer. In addition, enumeration analysis CTCs could be important for monitoring response to different therapeutic agents, thus guiding treatment cancer patients offering promise a more personalized approach. this article, we present new method that used automatic detection CTC blood, based on...
Parathyroid carcinoma is a rare malignant endocrine tumor accounting for only 0.5% to 5% of all primary hyperparathyroidism. Among these malignancies, 10-25% are nonfunctioning. After the review literature we could ascertain number 25 cases reported worldwide, since 1929, our case being 26th, but first with very aggressive pathology, treated chemotherapy scheme usually used neuroendocrine tumors. Considering facts, every single presented step forward in defying clinical presentation,...
Solid pseudopapillary tumor (SPT) of the pancreas is a rare pathological condition, representing less than 3% all exocrine pancreatic tumors. SPT usually occurs in young females, without notable symptoms, with low malignant potential and excellent prognosis.We conducted retrospective study during period January 2005 - 2015. patients admitted our institution were reviewed by describing demographic data, clinico-pathologic radiological features, therapeutic management prognosis...
Abstract This article analyzes the availability of different diagnostic procedures non-small cell lung cancer (NSCLC) and reimbursement landscape drugs for NSCLC in countries central southeastern Europe (CEE). A survey was conducted by Central European Cooperative Oncology Group. Results show that both diagnoses molecular alterations NSCLC, detection which is essential therapeutic decisions, varies widely between CEE. Not only “reflex” testing often substituted analyses performed “on...
Abstract Background Breast cancer, although the most frequently diagnosed malignant tumor in humans, has a less clear etiology compared to other frequent cancer types. Mouse-mammary virus (MMTV) is involved breast mice and dogs might play role of some cancers since an MMTV-like sequence was identified 20–40% samples Western Europe, USA, Australia parts world. The purpose our study identify DNA sequences tissue from patients who underwent curative surgery regional academic center Romania, EU....