A5034620211- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- CNS Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- CAR-T cell therapy research
- Vascular Tumors and Angiosarcomas
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Molecular Biology Techniques and Applications
- Pelvic floor disorders treatments
- Cutaneous Melanoma Detection and Management
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- Otolaryngology and Infectious Diseases
- MRI in cancer diagnosis
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Cutaneous lymphoproliferative disorders research
- AI in cancer detection
- Chronic Lymphocytic Leukemia Research
- Endometrial and Cervical Cancer Treatments
Institute of Oncology Prof. Dr. Ion Chiricuta
2018-2025
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2025
Grigore T. Popa University of Medicine and Pharmacy
2022-2025
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2024
Guy's and St Thomas' NHS Foundation Trust
2020-2024
Clinical Emergency Hospital Bucharest
2023
National Health Service
2022
MacEwan University
2019
Goethe University Frankfurt
2016-2018
University of Udine
2018
The aim was to predict survival of glioblastoma at 8 months after radiotherapy (a period allowing for completing a typical course adjuvant temozolomide), by applying deep learning the first brain MRI completion.
To retrospectively compare the local tumour response and survival rates in patients with non-colorectal cancer lung metastases post-ablation therapy using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA) microwave (MWA).Retrospective analysis of 175 computed tomography (CT)-guided sessions performed on 109 (43 males 66 females, mean age: 56.6 years). Seventeen 22 lesions underwent LITT treatment (tumour size: 1.2-4.8 cm), 29 49 RFA 0.8-4.5 cm) 63 104 MWA 0.6-5 cm). CT scans...
Neo-adjuvant therapy (NAT) is increasingly used in the clinic for treatment of breast cancer (BC). Pathological response to NAT has been associated with improved patients’ survival; however, current techniques employed assessing tumor have significant limitations. Small EVs (sEVs)-encapsulated miRNAs emerged as promising new biomarkers diagnosis and prediction. Therefore, our study aims explore predictive value these pathological BC. By employing bioinformatic tools, we selected a set...
Background and Objectives: Deep neck infections (DNIs) are severe diagnoses that can cause serious complications. However, there insufficient data to predict the evolution of this pathology. This study aims review microbiology DNIs identify factors influence prolonged hospitalization. Materials Methods: The present retrospective cohort observational analytical analyzed 138 patients with who were diagnosed received surgical treatment over a 8-year period. Results: Reduced lymphocyte...
Background: Breast cancer (BC) is the most frequently diagnosed in women and leading cause of cancer-related deaths globally. Carriers P/LP variants BRCA1, BRCA2, TP53, PTEN, CDH1, PALB2, STK11 genes have an increased risk developing BC, which why more guidelines recommend prophylactic mastectomy this group patients. Because traditional genetic testing expensive can delays patient management, radiomics based on diagnostic imaging could be alternative. This study aims to evaluate whether...
Abstract Radiopharmaceutical therapies offer a promising, targeted approach for treating cancers with limited options. The 5T4/trophoblast glycoprotein (encoded by TPBG) is an oncofetal cell surface antigen found on various cancer cells, including gastrointestinal, head and neck, non-small lung cancers. 5T4 associated stem properties, metastatic spread poor clinical outcomes in patients, while it minimally expressed or absent healthy adult tissue. Hence, ideal target tumor-directed...
History A 65-year-old woman presented to her primary care physician with a history of progressive abdominal pain mainly in the upper quadrants, nausea, and edema bilateral symmetric lower extremities. Other symptoms use medication or related drugs were denied. Physical examination findings normal. The serum lactate dehydrogenase level was 302 U/L (5.04 μkat/L) (reference range, <247 [4.12 μkat/L]), all other laboratory data within normal ranges. Electrocardiography chest radiography revealed...
atients with a limited number of lung metastases can hope for longer disease-free survival if both the primary tumor and are treated (1).Surgical resection is considered to be treatment choice oligometastases (2).If patients medically inoperable or refuse surgery, less invasive techniques such as stereotactic body radiation therapy percutaneous thermal ablations used.Amongst ablation techniques, RFA currently most widely employed method in malignancies has been subject research.MWA...
We use pulmonary interventional procedures for the diagnosis of diseases either benign or malignant lesions. Flexible bronchoscopy with without radial endobronchial ultrasound, convex-probe ultrasound and electromagnetic navigation are performed in centers experience diagnostic medicine. The method sedation ventilation is very important order to avoid handle success complications. Proper respiration during (or other interventional) a key factor. Apart from proper we have choose which decides...
During recent decades, understanding of the molecular mechanisms acute lymphoblastic leukemia (ALL) has improved considerably, resulting in better risk stratification patients and increased survival rates. Age, white blood cell count (WBC), specific genetic abnormalities are most important factors that define groups for ALL. State-of-the-art diagnosis ALL requires cytological cytogenetical analyses, as well flow cytometry high-throughput sequencing assays. An aspect diagnostic...
Abstract Background Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack specific molecular markers, increased phenotypic plasticity no clear clinicopathological features, assessment CSCs presence functionality solid tumors is challenging. While several potential such CD24/CD44, proposed, extent which they truly represent stem cell or merely provide static snapshots...
There are different breast cancer molecular subtypes with differences in incidence, treatment response and outcome. They roughly divided into estrogen progesterone receptor (ER PR) negative positive cancers. In this retrospective study, we included 185 patients augmented 25 SMOTE them two groups: the training group consisted of 150 validation cohort 60 patients. Tumors were manually delineated whole-volume tumor segmentation was used to extract first-order radiomic features. The ADC-based...
Since transcription factor Forkhead Box P3 (FoxP3) was identified as a specific regulatory T cell (Treg) marker, researchers have scrutinized its value potential novel therapeutic target or prognostic in various types of cancer with inconsistent results. The present analysis performed to assess the influence Treg FoxP3 expression on prognosis primary melanoma and evaluate correlations clinicopathological factors. We analyzed all eligible patients stage pT3 malignant melanomas treated...
Computed tomography (CT) and ultrasound-guided microwave ablations (MWA) are part of the established treatment liver tumours. In spite its potential advantages, magnetic resonance (MR) monitoring MWA did not enter clinical practice because lack compatible devices. The purpose current study was to prove feasibility real-time qualitative MR using a new MR-compatible device.We performed 27 experiments with different durations (5, 10 15 min) on an ex vivo bovine model device. We compared...
To retrospectively investigate the role of a contrast enhanced MRI (ceMRI) performed 24 h after microwave ablation (MWA) lung, in predicting local tumour progression (LTP) and detecting complications compared to an unenhanced CT.Forty-nine patients who underwent MWA 77 lung metastases between 2008 2015 were included. All received chest CT ceMRI (including T2 ceT1) MWA. The conspicuities peripheral rim ablated scored using 1-3 scales examinations. safety margin was measured directly (both...
Abstract Aims In overactive bladder (OAB) research, different biomarkers have been proposed as diagnostic tools and may be used to create individual patient profiles. Assessing the performance of would better outline their utility. Therefore, our aim was investigate value four urinary biomarkers: human brain derived neurotrophic factor (hBDNF), malondialdehyde (MDA), h nerve growth (hNGF) 8‐hydroxydeoxyguanosine in women with OAB. These are neurotrophins/oxidative stress markers that linked...
Background and Objectives: Prediction of response to therapy remains a continuing challenge in treating breast cancer, especially for identifying molecular tissue markers that best characterize resistant tumours. Microribonucleic acids (miRNA), known as master modulators tumour phenotype, could be helpful candidates predicting drug resistance. We aimed assess the association miR-375-3p, miR-210-3p let-7e-5p cancer tissues with pathological neoadjuvant (NAT) clinicopathological data. Material...
Gastric cancer is the 5th most common malignancy worldwide. Signet ring cell histology represents an aggressive subtype of gastric cancer, presenting at a younger age. Both breast and leptomeningeal metastases are rare locations tumor dissemination, requiring correct immediate diagnosis treatment. We present case 45-year old female with signet carcinoma who developed both left metastases, multiple chemotherapy lines. As far as we know, this first published in literature following lines...
Fine needle aspiration (FNA) is frequently the first noninvasive test used for diagnostic workup of lymphadenopathy. There have been many studies showing its usefulness, especially in conjunction with other techniques diagnosis lymphoma, but it remains inferior to histological examination. The data regarding this subject mostly reported from first-world countries, are scarce emerging economies. Thus, current study assesses agreement between fine flow cytometry (FNA FC) and histology...