A5060885442- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Mycotoxins in Agriculture and Food
- FOXO transcription factor regulation
- Prostate Cancer Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Cancer Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Advanced Proteomics Techniques and Applications
KTH Royal Institute of Technology
2024-2025
Science for Life Laboratory
2024-2025
Institute of Oncology Prof. Dr. Ion Chiricuta
2014-2024
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2023
Indiana University School of Medicine
2017
Indiana University – Purdue University Indianapolis
2017
University of Tartu
2013
Stockholm University
2012
Babeș-Bolyai University
2011
Cancer Institute (WIA)
2009-2010
The clinical outcome of BC patients receiving the same treatment is known to vary considerably and thus, there a compelling need identify novel biomarkers that can select would benefit most from given therapy predict outcome. aim this study was determine prognostic value CCAT2, long ncRNA recently characterized by our group overlapping SNP rs6983267, in patients. We first evaluated RT-qPCR ISH expression CCAT2 normal breast tissue further analyzed an independent set 997 primary with regard...
Cell-penetrating peptides (CPPs) are short cationic that penetrate cells by interacting with the negatively charged plasma membrane; however, detailed uptake mechanism is not clear. In contrary to conventional mode of action CPPs, we show here a CPP, PepFect14 (PF14), forms nanocomplexes oligonucleotides and their mediated class-A scavenger receptors (SCARAs). Specific inhibitory ligands SCARAs, such as fucoidin, polyinosinic acid, dextran sulfate, totally inhibit activity...
Chlamydia trachomatis is the most common sexually transmitted human pathogen. Infection results in minimal to no symptoms approximately two-thirds of women and therefore often goes undiagnosed. C. infections are a major public health concern because potential severe long-term consequences, including an increased risk ectopic pregnancy, chronic pelvic pain, infertility. To date, several point-of-care tests have been developed for diagnostics. Although many them fast specific, they lack...
<title>Abstract</title> A lab-in-a-fiber component was fabricated using an optical fiber and a capillary. It used in test suspension of fluorescently labeled unlabeled cells enabled detection the cells. Subsequently were selectively collected via suction into novel sampling technique reduced photobleaching cells, extending measurement time. The remained viable for downstream analysis. This platform’s low fabrication cost, simplicity, compatibility with standard laboratory equipment, capacity...
Abstract A lab-in-a-fiber component was fabricated using an optical fiber and a capillary. It used in test suspension of fluorescently labeled unlabeled cells enabled detection the cells. Subsequently were selectively collected via suction into novel sampling technique reduced photobleaching cells, extending measurement time. The remained viable for downstream analysis. This platform’s low fabrication cost, simplicity, compatibility with standard laboratory equipment, capacity fully...
Advanced squamous cervical cancer, one of the most commonly diagnosed cancers in women, still remains a major problem oncology due to treatment failure and distant metastasis. Antitumor therapy is both intrinsic acquired resistance; resistance often decisive for response. In this study, we investigated specific pathways molecules responsible baseline locally advanced cancer. Twenty-one patients with cell carcinoma were enrolled study. Primary biopsies harvested prior analyzed whole human...
Neo-adjuvant therapy (NAT) is increasingly used in the clinic for treatment of breast cancer (BC). Pathological response to NAT has been associated with improved patients’ survival; however, current techniques employed assessing tumor have significant limitations. Small EVs (sEVs)-encapsulated miRNAs emerged as promising new biomarkers diagnosis and prediction. Therefore, our study aims explore predictive value these pathological BC. By employing bioinformatic tools, we selected a set...
The major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been shown to exhibit antitumour activities in several tumour models. One of the possible mechanisms by which EGCG can inhibit cancer progression is through modulation angiogenesis signalling cascade. cells' ability tightly adhere endothelium a very important process metastatic process, because once disseminated into bloodstream cells must re-establish adhesive connections order extravasate target tissues. In this...
Composites based on sodium alginate, pullulan, and bioactive SiO2-CaO-P2O5 glass-ceramics with copper oxide were prepared as capsules. The obtained samples structurally characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), their bioactivity biocompatibility properties also tested both in vitro vivo XRD, FT-IR, SEM, high-resolution transmission microscopy. fibroblast osteoblast cell viability assays have shown good...
Abstract Background Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack specific molecular markers, increased phenotypic plasticity no clear clinicopathological features, assessment CSCs presence functionality solid tumors is challenging. While several potential such CD24/CD44, proposed, extent which they truly represent stem cell or merely provide static snapshots...
Abstract We hereby provide the initial portrait of lincNORS , a spliced lincRNA generated by MIR193BHG locus, entirely distinct from previously described miR-193b-365a tandem. While inducible low O 2 in variety cells and associated with hypoxia vivo, our studies show that is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this fine-tunes cellular sterol/steroid biosynthesis repressing expression pathway components. Mechanistically, function requires presence...
Breast cancer prognosis and treatment is highly dependent on the molecular features of primary tumors. These tumors release specific molecules into environment that trigger characteristic responses circulatory cells. In this study we investigated expression pattern 84 genes known to be involved in breast signaling peripheral blood patients with ER-, PR- The were grouped according Her2 Her2+ Her2- cohorts. Transcriptional analysis revealed 15 differentially expressed between two groups...