A5030604380- Peripheral Artery Disease Management
- Tea Polyphenols and Effects
- Diabetic Foot Ulcer Assessment and Management
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Tannin, Tannase and Anticancer Activities
- Lymphatic System and Diseases
- Colorectal Cancer Treatments and Studies
- Diagnosis and Treatment of Venous Diseases
- Phytochemicals and Antioxidant Activities
- Hepatocellular Carcinoma Treatment and Prognosis
- Cerebrovascular and Carotid Artery Diseases
- Abdominal vascular conditions and treatments
- Venous Thromboembolism Diagnosis and Management
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Aortic aneurysm repair treatments
- Photodynamic Therapy Research Studies
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Porphyrin and Phthalocyanine Chemistry
- Angiogenesis and VEGF in Cancer
- Healthcare and Venom Research
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2025
Institute of Oncology Prof. Dr. Ion Chiricuta
2011-2021
Spitalul Clinic Județean de Urgență Cluj-Napoca
2019
Yahoo (United Kingdom)
2017
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2011
Clinical Emergency Hospital Bucharest
2008
Previous studies indicate that green tea extract may inhibit breast cancer progression by blocking angiogenesis, although the molecular mechanisms are not well defined. Epigallocatechin-3-gallate (EGCG) is major biologically active component of tea. In this study we evaluated cell proliferation and relative gene expression vascular endothelial growth factor (VEGF) on Hs578T human line at 24, 48 72 hours after 10 microM EGCG treatment. Also, effect natural compound migratory behaviour based...
Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation SSC-4 human oral squamous carcinoma (OSCC), effect being dose- and time-dependent. In parallel was observed activation apoptosis autophagy, in response to exposure cells. Treatment with activates expression BAD, BAK, FAS, IGF1R, WNT11, ZEB1 genes inhibits CASP8, MYC, TP53. All these results suggest has an excellent potential become...
Breast cancer represents one of the most common forms in women worldwide, with an increase number newly diagnosed patients last decade. The role fatty acids, particularly a diet rich ω-3 and ω-6 polyunsaturated acids (PUFAs), breast development is not fully understood remains controversial due to their complex mechanism action. However, large animal models cell culture studies have demonstrated that high levels PUFAs inhibitory progression cancer, compared PUFAs. present review focused on...
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there significant interest understanding molecular signaling pathways that connect TNF-α with survival tumor In our experiments, we used as an vitro model for cell line Hs578T. The purpose this study to determine gene expression profiling apoptotic networks after blocking formation by using specially designed siRNA...
The major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been shown to exhibit antitumour activities in several tumour models. One of the possible mechanisms by which EGCG can inhibit cancer progression is through modulation angiogenesis signalling cascade. cells' ability tightly adhere endothelium a very important process metastatic process, because once disseminated into bloodstream cells must re-establish adhesive connections order extravasate target tissues. In this...
Regardless of recent progress, melanoma is very difficult to treat, mainly due the drug resistance modulated by tumor cells as well microenvironment (TME). Among immune recruited at site, associated macrophages (TAMs) are most abundant, promoting important tumorigenic processes: angiogenesis, inflammation and invasiveness. Furthermore, it has been shown that TAMs involved in mediating cells. Thus, present study, we used liposomal formulation prednisolone disodium phosphate (LCL-PLP) inhibit...
It is quite common for portal vein thrombosis to occur in subjects who present predisposing conditions such as cirrhosis, hepatobiliary malignancies, infectious or inflammatory abdominal diseases, hematologic disorders. The incidence of idiopathic non-cirrhotic patients remains low, and despite the intensive workup that performed these cases, up 25% there no identifiable cause. If untreated, complications arise include hypertension, cavernous transformation vein, gastroesophageal even small...
Background: As the global battle against COVID-19 pandemic endures, spread of Delta variant has introduced nuanced challenges, prompting a examination. Materials and Methods: We performed multilevel logistic regression analysis encompassing 197 patients, comprising 44 vaccinated individuals (V group) 153 unvaccinated counterparts (UV). These afflicted with SARS-CoV-2, were hospitalized between October 2021 February 2022 at department University Centre in Cluj-Napoca, Romania. compared...
Epithelioid hemangioendothelioma (EHE) is a rare, well-differentiated endothelial tumor with intermediate malignancy which develops more frequently from the peripheral veins, generally in lower limb. Bone EHE comprises less than 1% of bone neoplasms. We present case young man, 24-year-old, forearm secondary involvement distal radius. The location and extension allowed wide excision, without reconstruction radius, followed by adjuvant radiotherapy, subsequent favorable evolution. Based on...
In the present work, we investigated effect of epigallocatechin gallate (EGCG) on triple negative breast cancer cells (Hs578T) to reduce cell proliferation and evaluate early apoptotic signals. The dynamic monitoring Hs578T treated with EGCG using xCELLigence System confirm antiproliferative effects obtained by MTT test. induced significant increases in apoptosis at 48 72 h after treatment activation death pathways mRNA level. Significant gene expression differences were observed for 22...
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), association between TBS (tumor burden score), alpha-fetoprotein levels, Child–Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, main objective our research was analyze value HVPG, TE-LSM, TBS,...