A5043390427- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lipoproteins and Cardiovascular Health
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Organometallic Compounds Synthesis and Characterization
- Angiogenesis and VEGF in Cancer
- Crystal structures of chemical compounds
- Gold and Silver Nanoparticles Synthesis and Applications
- Organoselenium and organotellurium chemistry
- Ferroptosis and cancer prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Bird parasitology and diseases
- Coccidia and coccidiosis research
Babeș-Bolyai University
2015-2024
Spitalul Clinic Județean de Urgență Cluj-Napoca
2020
Utrecht University
2006-2010
Icahn School of Medicine at Mount Sinai
2010
Eindhoven University of Technology
2010
Iuliu Hațieganu University of Medicine and Pharmacy
2006
Atherosclerosis is an inflammatory disease causing great morbidity and mortality in the Western world. To increase anti-inflammatory action decrease adverse effects of glucocorticoids (PLP), a nanomedicinal liposomal formulation this drug (L-PLP) was developed intravenously applied at dose 15 mg/kg PLP to rabbit model atherosclerosis. Since atherosclerosis systemic disease, emerging imaging modalities for assessing atherosclerotic plaque are being developed. (18)F-Fluoro-deoxy-glucose...
The aim of this work was to use the quality-by-design (QbD) approach in development long-circulating liposomes co-loaded with curcumin (CUR) and doxorubicin (DOX) evaluate cytotoxic potential these vitro using C26 murine colon carcinoma cell line. Based on a risk assessment, six parameters, namely phospholipid, CUR DOX concentrations, phospholipid:cholesterol molar ratio, temperature during evaporation hydration steps pH phosphate buffer, were identified as factors for quality final product....
Prednisolone phosphate (PLP) encapsulated in long-circulating liposomes (LCLs) (LCL-PLP) exerts antitumor activity through the inhibition of tumor angiogenesis. It is known that tumor-associated macrophages (TAMs) play a crucial role growth as they are actively involved promoting and maintaining To gain more insight into antiangiogenic mechanisms LCL-PLP, this study aimed to investigate TAM mode action LCL-PLP B16.F10 melanoma-bearing mice. Our results show TAMs have pivotal function...
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs stabilized with Polyethylene glycol (PEG) and loaded doxorubicin (DOX). Small were efficiently enriched from melanoma cells cultured under metabolic stress by ultrafiltration coupled size exclusion chromatography (UF-SEC) characterized size,...
The main objective of our research is to develop tumor-targeted therapies that modulate the tumor microenvironment (TME) enhance therapeutic efficacy while minimizing side effects. Specifically, focus lies in two key strategies: targeting tumor-associated macrophages (TAMs) supress their protumor functions and utilizing extracellular vesicles (EVs) derived from dendritic cells intratumor drug delivery immunotherapy. We have previously explored potential statins, such as simvastatin (SIM),...
Doxorubicin is a member of the anthracycline class chemotherapeutic agents and among most effective treatments available up to date. However, its clinical use significantly limited by severe cardiotoxic effects. The purpose this study investigate transcriptomic alterations that occur in rat model doxorubicin-induced cardiotoxicity. Our results reveal significant dysregulations cardiac metabolism provide insights into molecular mechanisms underlying damage produced treatment. analysis...
The rhizosphere microbial communities of Lotus tenuis in Hg-contaminated soils demonstrate remarkable resilience, maintaining stable bacterial and fungal diversity across a broad contamination gradient (40-1964 mg Hg kg -1 soil). Despite significant shifts community structure compared to control from uncontaminated soil, alpha remained largely unaffected, likely due widespread merA -mediated detoxification. These findings align with the stress hypothesis, indicating that facilitative...
Chemoresistance continues to remain a significant barrier the effective treatment of various cancers, including melanoma. Previous studies, our own, have demonstrated limited efficacy doxorubicin (DOX) against melanoma cells and tumors, both in vitro vivo, primarily due acquired chemoresistance. The lack favorable outcomes metastatic patients treated with liposomal DOX highlights need identify early DOX-induced resistance biomarkers develop combination strategies improve efficacy. This study...
Quality by design principles (QbD) were used to assist the formulation of prednisolone-loaded long-circulating liposomes (LCL-PLP) in order gain a more comprehensive understanding preparation process. This approach enables us improve final product quality terms liposomal drug concentration, encapsulation efficiency and size, minimize variability. A 19-run D-optimal experimental was study impact highest risk factors on PLP concentration (Y1- μg/ml), (Y2-%) size (Y3-nm). Out six investigated...
At present, multifunctional noble metal-based nanocomposites are extensively investigated for their potential in performing cellular imaging, diagnostics, and therapy by integration of unique plasmonic properties with the spectroscopic expression therapeutic activity appropriate drug. In this work, we report fabrication 3-dimensional (3-D) close-packed nanoassemblies gold nanoparticles controlling aggregation individual solution subsequent stabilization formed aggregates Pluronic block...
The goal of the current study was to investigate pharmacokinetic profile, tissue distribution and adverse effects long-circulating liposomes (LCL) with curcumin (CURC) doxorubicin (DOX), in order provide further evidence for previously demonstrated enhanced antitumor efficacy colon cancer models. studies were carried out healthy rats, following i.v. injection a single dose LCL-CURC-DOX (1 mg/kg DOX). For study, DOX concentration tumours, heart liver measured after administration two doses...
Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many the diseases in which glucorticoids routinely administered featured by angiogenesis enhanced capillary permeability, permitting targeted delivery using long-circulating drug systems. By encapsulation liposomes, levels site pathology markedly higher, increasing prolonging therapeutic efficacy models rheumatoid arthritis, multiple sclerosis, cancer.
Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types malignancies. However, its low water solubility the toxicity associated with administration high doses recommend it encapsulation in carriers able to deliver therapeutic dose tumor. In this work, liposomes long-circulating properties were proposed as delivery systems SIM. The objective study was optimize formulation SIM-loaded (LCL-SIM) by using D-optimal experimental design....
Regardless of recent progress, melanoma is very difficult to treat, mainly due the drug resistance modulated by tumor cells as well microenvironment (TME). Among immune recruited at site, associated macrophages (TAMs) are most abundant, promoting important tumorigenic processes: angiogenesis, inflammation and invasiveness. Furthermore, it has been shown that TAMs involved in mediating cells. Thus, present study, we used liposomal formulation prednisolone disodium phosphate (LCL-PLP) inhibit...
An increasing number of studies published so far have evidenced the benefits Simvastatin (SIM) and Doxorubicin (DOX) co-treatment in colorectal cancer. In view this, current study aimed to investigate pharmaceutical development liposomes co-encapsulating SIM DOX, by implementing Quality Design (QbD) concept, as a means enhance antiproliferative effect co-formulation on C26 murine colon cancer cells co-cultured with macrophages. It is known that quality profile dependent critical attributes...