A5009971287- Nanoparticles: synthesis and applications
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- melanin and skin pigmentation
- Nanoparticle-Based Drug Delivery
- Dental materials and restorations
- Chemotherapy-induced cardiotoxicity and mitigation
- Skin Protection and Aging
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Curcumin's Biomedical Applications
- Moringa oleifera research and applications
- Ion channel regulation and function
- Immunotherapy and Immune Responses
- Botanical Research and Applications
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Natural Antidiabetic Agents Studies
- Dental Implant Techniques and Outcomes
- Gut microbiota and health
- Cardiac electrophysiology and arrhythmias
- Dermatology and Skin Diseases
- Liver Disease Diagnosis and Treatment
Iuliu Hațieganu University of Medicine and Pharmacy
2016-2025
Hai phong University Of Medicine and Pharmacy
2023
Deutsche Forschungsgemeinschaft
2018
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2011-2017
Spitalul Clinic Județean de Urgență Cluj-Napoca
2015
Heidelberg University
2010-2012
University Hospital Heidelberg
2010-2011
Abstract Drug-induced cardiotoxicity is a life-threatening side effect of doxorubicin (DOX) treatment that impacts patient prognosis and survival. In the majority cases, acute clinical form often remains asymptomatic, with few patients presenting rather nonspecific electrocardiographic abnormalities. While chronic toxicity has been more widely studied, alterations appearing in are much less investigated. Thus, our vivo study aimed to evaluate process DOX-induced myocardial by investigating...
The clinical performances of dental materials depend on their mechanical profiles, determining long-term deformation and wear resistance. This paper describes a study the properties, water absorption morphological properties polymethyl methacrylate (PMMA) resin enriched with graphene-silver nanoparticles (Gr-Ag). Two different concentrations—1 2 wt.%—of Gr-Ag were loaded into PMMA material. For characterization, compression behavior, flexural strength tensile evaluated. Optical microscopy in...
In recent years, escitalopram (ESC) has been suggested to have different mechanisms of action beyond its well known selective serotonin reuptake inhibition. The aim this study is investigate the effects on oxidative stress, apoptosis, brain-derived neurotrophic factor (BDNF), Methyl-CpG-binding protein 2 (MeCP2), and oligodendrocytes number in brain chronic unpredictable mild stress-induced depressed rats. animals were randomised four groups (8 each group): control, stress + ESC 5 5/10. was...
The 1:1 cocrystal of the antifungal agent ketoconazole with p-aminobenzoic acid was successfully crystallized and systematically characterized by a physical pharmacological point view. Crystal structure determination confirmed identity, giving full insight in its crystal packing degree disorder. Powder dissolution measurements revealed 10-fold aqueous solubility increase that induces 6.7-fold oral bioavailability improvement compared to ketoconazole. In vitro cell assays showed good toxicity...
Chronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension the wound healing time, and improper care can lead more problems in patients. Smart dressings that provide controlled drug release significantly improve process. In this paper, alginate beads with white lily leaf extract were prepared tested for chronic healing. The obtained characterized by scanning electron microscopy (SEM) Fourier...
Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and considered an important potential animal model for human lung cancer. The precise mechanisms of OPA oncogenesis are still uncertain. transcription factor signal transducer activator 3 (STAT3) activated interleukin-6 (IL-6) in many cancers, but this aspect unknown OPA. We therefore aimed to evaluate the expression IL-6 STAT3 its role carcinogenesis. Lung tissues from 9 grossly normal JRSV-negative 20...
Background . The antimicrobial activity of the Equisetum arvense L. extract and mechanisms involved in vitro effects on endothelial vascular cells exposed to hyperosmotic stress were evaluated. Methods Antimicrobial was evaluated by disk diffusion method minimum inhibitory concentration (MIC) determination, oxidative stress, inflammation, apoptosis, pretreatment with L., caffeic acid, cathechin, quantified. Results results have shown that exhibited antibacterial only pathogenic gram‐positive...
To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition also nitro-oxidative stress apoptosis in hippocampus cerebellum offsprings.Pregnant Wistar rats were orally administered substances from day 10 gestation until 21. Six weeks postpartum, six male offsprings each group used for behavioral evaluation determination oxidative apoptosis.Both groups exhibited hyperactivity anxiety especially...
Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was evaluate effects curcumin (CUR) on spatial cognition, ambulatory activity, blood brain oxidative levels. ERK/NF-κB signaling pathway histopathological changes hippocampus frontal lobe, diazepam-treated rats, were also analyzed. animals divided into 4 groups: control,...
Schiff bases (SBs) are chemical compounds displaying a significant pharmacological potential. They able to modulate the activity of many enzymes involved in metabolism and found among antibacterial, antifungal, anti-inflammatory, antioxidant, antiproliferative drugs. A new thiazolyl-triazole SB was obtained characterized by elemental spectral analysis. The antibacterial antifungal ability evaluated against Gram-positive Gram-negative bacteria three Candida strains. showed good L....