The bioactive glasses can lead to the promotion of growth granulation tissue, while gold nanoparticles (AuNPs) induce acceleration wound healing including tissue regeneration, connective formation, and angiogenesis. aim this study was evaluate impact using glass (BG) BG-AuNPs composites on skin in experimental rat models for 14 days. Sol-gel derived BGs mixed with Vaseline at 6, 12 18 wt% were used repair response skin. During process healing, granulomatous reaction observed treated...

The 1:1 cocrystal of the antifungal agent ketoconazole with p-aminobenzoic acid was successfully crystallized and systematically characterized by a physical pharmacological point view. Crystal structure determination confirmed identity, giving full insight in its crystal packing degree disorder. Powder dissolution measurements revealed 10-fold aqueous solubility increase that induces 6.7-fold oral bioavailability improvement compared to ketoconazole. In vitro cell assays showed good toxicity...

The main objective of this research is to demonstrate the biocompatibility two experimental graphene dental materials by in vitro and vivo tests for applications dentistry. novel materials, including one restorative composite cement, were subjected cytotoxicity implantation using a rat model non-critical mandibular defect. In induced on human follicle stem cells (restorative composite) dysplastic oral keratinocytes (dental cement) was investigated at 37 °C 24 h. After implantation, 7 weeks,...

Inflammation and oxidative stress are important pathways in the development of liver fibrosis following biliary obstruction.Aim: To evaluate effects low dose dexamethasone chitosan, a natural compound with no side-effects, on damage caused by bile duct ligation rats.Materials methods: Fifty female Wistar rats, randomly equally divided 5 groups: I (SHAM) underwent only laparotomy, II (BDL) ligation, III (DEX) 0.125 mg/kg i.m. daily, IV (CS) 1 chitosan gavage group V (DEX+CS), both substances....

This study aims to investigate the effect of new natural photosensitizers (PS) (based on oregano essential oil, curcuma extract, and arnica oil) through in vitro cytotoxicity biological tests rat-induced periodontal disease, treated with photodynamic therapy (aPDT). The PS was performed human dental pulp mesenchymal stem cells (dMSCs) keratinocyte (HaCaT) cell lines. Periodontal disease induced by ligation first mandibular molar 25 rats, which were divided into 5 groups: control group,...

In recent years, it has been increasingly suggested that the consumption of natural polyphenols, in moderate amounts, is beneficial for health. The aim this study was to investigate efficacy a red wine (the administered dose 7 mL/kg/day being equivalent ~16.5 mg/kg/day total polyphenols) compared white ~1.7 polyphenols), on prevention acrylamide-induced subacute hepatic injury and oxidative stress Wistar rats. Hepatic damage due acrylamide intoxication 250 µg/kg body weight, 28 days, by...

Background: Diabetes mellitus (DM) is a chronic endocrine-metabolic disorder associated with endothelial dysfunction. Hyperglycemia, dyslipidemia and abnormal nitric oxide-mediated vasodilatation are the major causal factors in development of dysfunction DM. The prevention may be first target against appearance atherosclerosis cardiovascular diseases. We have investigated synergistic protective effects quercetin administration moderate exercise training on thoracic aorta injuries induced by...

In veterinary medicine congenital abnormalities of the diaphragm and pericardium are rare, idiopathic malformations, being reported mainly in dogs. This report documents an unusual case developmental defects a foal consisting diaphragmatic hernia concurrent with pericardial aplasia.Following normal delivery, full term, female Friesian stillborn placenta was presented for necropsy. External morphological examination indicated normally developed foal. At necropsy, large oval defect...

The silver content of the skin regeneration ointments can influence its process but in meantime, it take benefit antibacterial properties by avoiding bacterial infection an open wound. In current study, healing and capacity bioactive glass with spherical gold nanocages (BGAuIND) Vaseline were evaluated vivo comparing (BG)-Vaseline (BGAuSP)-Vaseline ointments. Spherical are stabilized as a consequence BGAuIND exhibits great activity. Histological examination cutaneous tissue performed on day...

The aim of the present report is to describe a novel successful treatment approach for metaldehyde poisoning in dog: intravenous lipid emulsion therapy (ILE). A 2.5-month-old female Labrador Retriever was referred Emergency Department following deliberate ingestion metaldehyde-containing granular bait. Severe continuous tonic-clonic activity, muscle tremors, loss consciousness, diffuse congestion oral mucosa, tachycardia, tachypnoea and nystagmus were observed upon admission. Additional...

Summary Poisoning is a frequent problem in domestic animals. Horses are the third most commonly affected species and pesticides one of main causes toxicosis. Here within reviewed toxicoses where it emerges that misuse accidental exposure. Rodenticides, acetylcholinesterase insecticides followed by herbicides cause toxicosis effects emerging chemicals being reported. Metaldehyde still problem, together with methiocarb. No information has been reported on poisoning pesticide mixtures.

<b>Background</b> Lower limb ulcers are a major source of morbidity and mortality in diabetic patients. Surgical coverage these wounds is fraught with high complication rate. Although clinically perforator flaps lead to good results patients, there little experimental data support this finding. <b>Methods</b> A total 60 Wistar rats were randomly assigned either the (<i>n</i> = 30) or control group. Diabetes was induced by streptozotocin injection at 50 mg/kg body weight confirmed blood...

The purpose of this study was to assess the histological changes occurring in vagina and vulva ovariectomised female rats, as well response administration injectable oestrogens.We used 30 Wistar white distributed follows: group 1 - control group, 2 operated but untreated groups 3, 4 5 which oestrogenic treatment administered (Estradiol, Estradurin, Sintofolin) at a dosage 0.2 mg/rat/day. After 14 days treatment, all animals were sacrificed vaginal vulvar biopsies taken from groups.In 2, we...

Abstract To investigate the effects of PEG-coated gold nanoparticles on ablation zone volumes following in vivo radiofrequency porcine liver. This prospective study was performed institutional animal care and committee approval used. Radiofrequency ablations were livers ten Sus scrofa domesticus swines. During each ablation, 10 mL (mL) Peg-coated at two different concentrations (0.5 mg/mL 0.01 mg/mL) injected through electrode channel into target zone. For control group, physiological saline...

Epidemiological studies in domestic animal populations can deliver useful details concerning the incidence of neoplastic lesions, which may aid identification risk factors.In proposed study, we considered and prevalence tumors dogs Voula (a suburb area Athens, Greece) Cluj-Napoca (Romania) for a period 10 years.The obtained data were compared order to observe main differences suggested regions.The collected from records Pathology Department (Faculty Veterinary Medicine, Cluj-Napoca, Romania)...

Double chambered right ventricle (DCRV) is a congenital heart anomaly where the divided into two chambers. We describe, for first time, an unusual combination of DCRV combined with some other defects.A 1.2-year-old Golden Retriever was presented lethargy, exercise intolerance and ascites. Physical examination revealed irregularly irregular pulse grade V/VI, systolic, cranial murmur. Electrocardiography widened splintered QRS complexes bundle-branch block pattern. Radiography demonstrated...

Copper is an essential trace element but becomes toxic in overexposed animals. Sheep are the domestic species most prone to chronic copper poisoning, as a slight increase dietary concentration can lead liver accumulation and development of clinical signs this species. Common sources diet feed additives mineral supplements, which commonly used pigs poultry. Recently, new supplements were registered for animal nutrition, including bilysinate. This study describes episode presumed poisoning...

Development of cocrystals through crystal engineering is a viable strategy to formulate poorly water-soluble active pharmaceutical ingredients as stable crystalline solid forms with enhanced bioavailability. This study presents controlled cocrystallization process by cooling for the 1:1 cocrystal Ketoconazole, an antifungal class II drug Fumaric acid coformer. was successfully set up following meta-stable zone width determination in acetone–water 4:6 (V/V) and pure ethanol. Considering...

INTRODUCTION The technique described in this protocol was first applied chicken embryos to visualize the circulatory system. following method is an adaptation of “classic” mouse. basic procedure dissect 12.5-dpc (days post-coitus) or older with intact yolk sac and placenta while circulation still active. India ink then injected slowly into a branch vitelline vein sac. carbon particles are distributed arterial system by beating heart. After fixation clearing, three-dimensional structure fetal...

This case report describes the pathological findings of multiple congenital cardiac defects in a 2-year-old female Shetland pony with clinical signs chronic respiratory distress. Persistent truncus arteriosus (PTA) type IV, interventricular septal defect, overriding aorta, pulmonary trunk agenesis, arteries arising from descending and compensatory right ventricular hypertrophy were observed.