A5058906157- Spectroscopy Techniques in Biomedical and Chemical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Spectroscopy and Chemometric Analyses
- Essential Oils and Antimicrobial Activity
- Protein Interaction Studies and Fluorescence Analysis
- Garlic and Onion Studies
- X-ray Diffraction in Crystallography
- Advanced Nanomaterials in Catalysis
- Antibiotics Pharmacokinetics and Efficacy
- Melamine detection and toxicity
- Berberine and alkaloids research
- Advanced Chemical Sensor Technologies
- Reproductive System and Pregnancy
- Enzyme function and inhibition
- Aquatic Ecosystems and Phytoplankton Dynamics
- Salmonella and Campylobacter epidemiology
- Algal biology and biofuel production
- Chemical Thermodynamics and Molecular Structure
- Crystal structures of chemical compounds
- Synthesis of Tetrazole Derivatives
- Pharmacological Effects of Natural Compounds
National Institute for Research and Development of Isotopic and Molecular Technologies
2018-2025
Babeș-Bolyai University
2018-2023
Nonculture-based tests are gaining popularity and upsurge in the diagnosis of invasive fungal infections (IFI) fostered by their main asset, reduced analysis time, which enables a more rapid diagnosis. In this project, three different clinical isolates relevant filamentous species were discriminated using (less than 5 min) sensitive surface-enhanced Raman scattering (SERS)-based detection method, assisted chemometrics. The holistic evaluation SERS spectra was performed employing appropriate...
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation new diagnostic and therapeutic tools. A full characterization designed product includes evaluation its impact on specific biological systems, including study cell behavior as response to that particular interaction. Copper copper-based nanoparticles (CuO NPs) have emerged valuable building blocks various biomedical applications such antibacterial disinfecting agents infectious...
The allicin pleiotropic effects, which include anti-inflammatory, anti-oxidant, anti-tumoral, and antibacterial actions, were well demonstrated correlated with various molecular pathways. immunostimulatory mechanism of has not been elucidated; however, there is a possible cytokine stimulation from immunoglobulin release caused by allicin. In this study, when Wistar female rats CD19+ lymphocytes treated three different doses allicin, immunoglobulins, glutathione, oxidative stress markers...
Recently, the possibility of creating surface-enhanced Raman scattering (SERS)-based biosensors for rapid detection bacteria has been widely explored. For this purpose, we used ultrasensitive SERS spectroscopy to detect and identify common bacteria's spectral profiles in different experimental conditions: using situ-synthesized silver colloids (Bacteria@AgNPs) incubation biomass colloids. Moreover, a label-free SERS-based protocol was optimized influences taxonomic affiliation time-dependent...
Nodularin (NOD) is a potent toxin produced by Nodularia spumigena cyanobacteria. Usually, NOD co-exists with other microcystins in environmental waters, class of cyanotoxins secreted certain cyanobacteria species, which makes identification difficult the case mixed toxins. Herein we report complete theoretical DFT-vibrational Raman characterization along experimental drop-coating deposition (DCDR) technique. In addition, used vibrational to probe SERS analysis using colloidal silver...
Development of cocrystals through crystal engineering is a viable strategy to formulate poorly water-soluble active pharmaceutical ingredients as stable crystalline solid forms with enhanced bioavailability. This study presents controlled cocrystallization process by cooling for the 1:1 cocrystal Ketoconazole, an antifungal class II drug Fumaric acid coformer. was successfully set up following meta-stable zone width determination in acetone–water 4:6 (V/V) and pure ethanol. Considering...
Vibrational properties and structural behavior upon ultraviolet (UV) irradiation are reported here for DNAs isolated from three serovars of Salmonella bacteria, respectively (S. enteritidis, S. infantis typhimurium) by using Fourier transform infrared spectroscopy (FT-IR). The FT-IR absorbance spectra were recorded bacterial DNAs, control UV irradiated samples (30 min, 1 h, h 30 min), respectively, presented in the wavenumber ranges 800 to 1800 cm−1 3000 4000 cm−1, respectively. Molecular...
So far, in some of our previous works, we have managed to rapidly (within minutes) identify and discriminate pathogens by using surface-enhanced Raman scattering (SERS) spectroscopy with a single cell sensitivity. Having more user friendly robust system, which could be used not only experts, would the next step. In order meet goal, developed an experimental setup, including in-house built microfluidic device optimized SERS detection common bacterial device. The main components system are...
Raman spectra of oxacillin (OXN), carbenicillin (CBC), and azlocillin (AZL) are reported for the first time together with their full assignment normal modes, as calculated using Density Functional Theory (DFT) methods B3LYP exchange-correlation functional coupled to 6-31G(d) 6-311+G(2d,p) basis sets. Molecular docking studies were performed on five penicillins, including OXN, CBC, AZL. Subsequently, chemical reactivity correlated efficiency towards specific pathogenic strains revealed by...