A5005567217- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Drug Solubulity and Delivery Systems
- Cultural Heritage Materials Analysis
- Building materials and conservation
- Chemical Thermodynamics and Molecular Structure
- Conservation Techniques and Studies
- Nanoparticles: synthesis and applications
- Microencapsulation and Drying Processes
- Adsorption and biosorption for pollutant removal
- Thermal and Kinetic Analysis
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Nanomaterials for catalytic reactions
- Analytical Methods in Pharmaceuticals
- Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Berberine and alkaloids research
- Hydrogels: synthesis, properties, applications
- Nonlinear Optical Materials Research
- Analytical Chemistry and Chromatography
- Protein Interaction Studies and Fluorescence Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Phenothiazines and Benzothiazines Synthesis and Activities
National Institute for Research and Development of Isotopic and Molecular Technologies
2016-2025
Service de la Santé Publique
2008
The molecular interaction between curcumin (CCM), and whey protein concentrate (WPC), was studied by using fluorescence measurements. binding number (n), constant (KS) thermodynamic parameters (ΔG0, ΔH0 ΔS0) were determined at different temperatures various pH values. Thermodynamic approach revealed the highest stability of 1CCM-1WPC complex in acidic medium (e.g., stomach fluid 1.5), decreasing alkaline small intestine 7.4 to 8.0). CCM-WPC as spray-dried powder further investigated XRD,...
Background.Infections of renal grafts with Candida species can induce life-threatening complications in the recipient.
Crystal structures of ketoconazole oxalate salt (1) and three co-crystals with fumaric (2), succinic (3), adipic (4) acids in 1:1 stoichiometry were determined by single-crystal X-ray diffraction which 1 forms dimers involved ionic interaction the imidazole ring molecules, while 2–4 display 4-member circuit networks between hydrogen-bonded coformer molecules. The co-crystal nature 1–4 was confirmed combining diffraction, ss-NMR, lattice energy calculations. Ketoconazole molecules show highly...
The 1:1 cocrystal of the antifungal agent ketoconazole with p-aminobenzoic acid was successfully crystallized and systematically characterized by a physical pharmacological point view. Crystal structure determination confirmed identity, giving full insight in its crystal packing degree disorder. Powder dissolution measurements revealed 10-fold aqueous solubility increase that induces 6.7-fold oral bioavailability improvement compared to ketoconazole. In vitro cell assays showed good toxicity...
Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due natural compounds and their potential chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), a 1:1 mixture the two extracts (MNPs). These NPs characterized S/TEM, EDX, XRD, FTIR methods, biological activity was assessed in vitro on normal keratinocytes (HaCaT) skin melanoma cells (A375). All had...
In this study the adsorption and photodegradation capabilities of modified multi-walled carbon nanotubes (MWCNTs), using tartrazine as a model pollutant, is demonstrated. MWCNT-COOH/Fe3O4 MWCNT-COOH/Fe3O4/NiO nanocomposites were prepared by precipitation metal oxides in presence MWCNTs. Their properties examined X-ray diffraction powder (XRD), Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning (SEM), Raman spectroscopy, synchrotron-based...
Chronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension the wound healing time, and improper care can lead more problems in patients. Smart dressings that provide controlled drug release significantly improve process. In this paper, alginate beads with white lily leaf extract were prepared tested for chronic healing. The obtained characterized by scanning electron microscopy (SEM) Fourier...
Abstract Natural drug products with limited water solubility pose a challenge to the pharmaceutical industry in terms of developing an appropriate dissolution procedure. Like other flavonoids, icariside II (ICS) also faces challenges such as insufficient bioavailability caused by its poor solubility, limiting oral therapeutic applications food supplement. Consequently, new approaches are needed across board focusing on aqueous enhancement. This work aimed use whey protein concentrate (WPC)...
Understanding cellular interaction with nanomaterials represents a subject of great interest for the validation new diagnostic and therapeutic tools. A full characterization designed product includes evaluation its impact on specific biological systems, including study cell behavior as response to that particular interaction. Copper copper-based nanoparticles (CuO NPs) have emerged valuable building blocks various biomedical applications such antibacterial disinfecting agents infectious...
Graphene decorated with gold nanoparticles (Au-rGO) was obtained in a single-step synthesis by exfoliating graphite rods via pulses of current. The morphological and structural features Au-rGO were explored TEM/SEM/EDX XRD techniques. TEM images reveal the co-existence thin transparent sections corresponding to few-layer graphene along darker regions multi-layer graphene. Such mixture further confirmed examination sample. next deposited on top screen-printed electrode (Au-rGO/SPE), its...
This study aimed at unprecedented physical and chemical evaluation of the 'green plastics' polyhydroxyalkanoates (PHAs), in an extremely halotolerant Halomonas elongata strain 2FF under high-salt concentration.The investigated bacterial was isolated from surface water hypersaline Fără Fund Lake. The 16S rRNA gene sequence phylogeny phenotypic analysis indicated that isolate belonged to H. elongata. PHA inclusions were observed by Sudan Black B, Nile Red staining, transmission electron...
The main purpose of the present paper is to emphasize non-invasive effect some new prepared nanomaterials on skin diseases (psoriasis) together with procedures obtain them. These materials are based gold nanoparticles and natural compounds extracted from native plants Adoxaceae family (European cranberrybush – Viburnum opulus L. European black elderberry Sambucus nigra L.) possess a known anti-inflammatory activity mainly due their high content anthocyanins other polyphenols. were...
In this data article, we present supplementary related to the research article entitled "Starch-coated green synthesized magnetite nanoparticles for removal of textile dye Optilan Blue from aqueous media" Stan et al., 2019. Data interpretations are included in The starch-coated Fe3O4 (ST-coated NPs) were analyzed by scanning electron microscopy (SEM) and high resolution transmission (HRTEM) illustrate shape surface coating nanoparticles. Moreover, Brunauer-Emmett-Teller (BET) technique was...
The crystal structure of the inclusion complex β-cyclodextrin with lipoic acid was determined from laboratory powder diffraction data. Thermogravimetric data used to estimate number water molecules in structure. Lipoic is included through its primary face five-membered ring reaching center plane cyclodextrin cavity and fatty chain adopting a bent conformation. form channel-like packing which stabilized by guest–host hydrogen bonding close contacts, host–host intermolecular interactions...
The article investigated the antioxidant and antimicrobial activity of extracts from two aromatic plants-Satureja hortensis L. (SE) Rosmarinus officinalis (RE), encapsulated in alginate, on-yogurt properties. encapsulation efficiency was controlled by FTIR SEM analysis. In both extracts, individual polyphenol content determined HPLC-DAD-ESI-MS. total were spectrophotometrically quantified. properties SE RE against gram-positive bacteria (Bacillus cereus, Enterococcus faecalis, Staphylococcus...
Different microorganisms are present in nature, some of which assumed to be hazardous the human body. It is crucial control their continuing growth improve life. Nanomaterial surface functionalization represents a current topic continuous evolution that supports development new materials with multiple applications biology, medicine, and environment. This study focused on antibacterial activity different nanocomposites based functionalized multi-walled carbon nanotubes against four common...
The selective production of crystalline polymorphs is an outstanding problem in solid-state chemistry. In this study, the preparation a new urea solid form based on pure and oxalic acid (1:1), by grinding components at room temperature. resulted compound was investigated X-ray powder diffraction (PXRD), thermal analysis (DSC, PPE) infrared (FTIR) spectroscopy. difference between PXRD patterns urea-oxalic starting evidenced compound. Using method, lattice parameters were determined. Some...
In the present study, effects of copper oxide nanoparticles (CuO NPs) on bioactive compounds, ultrastructural modifications which can occur, and elemental content wheat were investigated. Changes in plants grown presence or absence CuO NPs estimated. The application decreased amounts chlorophylls carotenoids increased polyphenols antioxidant capacity. Ultrastructural analysis showed that treated with negatively affected. Soil amending completely inhibited accumulation seventeen elements,...