A5075063743- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Essential Oils and Antimicrobial Activity
- Carbon and Quantum Dots Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plasmonic and Surface Plasmon Research
- Photoacoustic and Ultrasonic Imaging
- Protein Interaction Studies and Fluorescence Analysis
- Graphene research and applications
- Laser-Ablation Synthesis of Nanoparticles
- Retinal Development and Disorders
- Quantum Dots Synthesis And Properties
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
- SARS-CoV-2 detection and testing
Babeș-Bolyai University
2016-2025
Spitalul Clinic Județean de Urgență Cluj-Napoca
2017
Technical University of Cluj-Napoca
2015
The approach of combining different mechanisms antibacterial action by designing hybrid nanomaterials provides a new paradigm in the fight against resistant bacteria. Here, we present method for synthesis silver nanoparticles enveloped biopolymer chitosan. aims at production bionanocomposites with enhanced properties. We find that chitosan and act synergistically two strains Gram-positive Staphylococcus aureus (S. aureus). As result exhibit higher activity than any component acting alone....
There is a need to design highly sensitive plasmonic sensors which impart good biocompatibility and optical stability detect low levels of analytes in biological media. In this study we report the formation chitosan-coated silver nanoparticles triangular shape solution by synergistic action chitosan trisodium citrate presence seeds ascorbic acid. It has been revealed that these anisotropic entrapped biopolymeric shells are particularly stable can be successfully used as versatile substrates...
The effectiveness of a therapeutic agent for cancer stands in its ability to reduce and eliminate tumors without harming the healthy tissue nearby. Nanoparticles peripherally conjugated with targeting moieties offer major improvements therapeutics through site specificity. In this study we demonstrate approach by folate receptor NIH:OVCAR-3 human ovary cell line. Herein used silver nanotriangles which were biocompatibilized chitosan (bio)polymer, labeled para-aminothiophenol (pATP) Raman...
In this work, we developed a new pH- and temperature-responsive nanochemotherapeutic system based on Doxorubicin (DOX) noncovalently bound to biosynthesized gelatin-coated gold nanoparticles (DOX-AuNPs@gelatin). The real-time release profile of DOX was evaluated at different pH values (7.4, 5.3, 4.6) temperatures (22-45 °C) in aqueous solutions, its therapeutic performance examined vitro against MCF-7 breast cancer cells. TEM, dark-field scattering, wide-field fluorescence microscopy...
C-reactive protein (CRP) represents an early clinical biomarker that indicates the presence of inflammatory or infectious conditions in human body. Today's procedures approved by Food and Drug Administration (FDA) imply expensive equipment highly trained personnel to perform test. Therefore, a new diagnostic method with high detection efficiency less cost is urgently needed for delivering rapid timely results point-of-care (POC) service.
Surface-enhanced Raman spectroscopy (SERS) is a technique that has become widely used for identifying and providing structural information about molecular species in low concentration. There an ongoing interest finding optimum particle size, shape spatial distribution optimizing the SERS substrates pushing sensitivity toward single-molecule detection limit. This work reports design of novel, biocompatible substrate based on small clusters anisotropic silver nanoparticles embedded film...
In this study we present a clean, nontoxic, environmentally friendly synthesis procedure to generate large variety of gold nanoparticles (GNPs) by using chitosan, biocompatible, biodegradable, natural polymer, as reducing and stabilizing agent. The formation gold–chitosan nanocomposites was characterized UV–vis absorption spectroscopy, transmission electron microscopy (TEM), x-ray diffraction (XRD) Raman spectroscopy. results show that the reaction temperature plays crucial role in...
There is a need for new strategies noninvasive imaging of pathological conditions within the human body. The approach combining unique physical properties noble-metal nanoparticles with their chemical specificity and an easy way conjugation open up routes toward building bio-nano-objects biomedical tracking imaging. This work reports design assessment novel class biocompatible, highly sensitive SERS nanotags based on chitosan-coated silver nanotriangles (Chit-AgNTs) labeled...
Abstract Early medical diagnostic in nanomedicine requires the implementation of innovative nanosensors with highly sensitive, selective, and reliable biomarker detection abilities. In this paper, a dual Localized Surface Plasmon Resonance - Enhanced Raman Scattering (LSPR- SERS) immunosensor based on flexible three-dimensional (3D) gold (Au) nanocups platform has been implemented for first time to operate as relevant “proof-of-concept” specific antigen-antibody binding events, using human...
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs stabilized with Polyethylene glycol (PEG) and loaded doxorubicin (DOX). Small were efficiently enriched from melanoma cells cultured under metabolic stress by ultrafiltration coupled size exclusion chromatography (UF-SEC) characterized size,...
Abstract In this work, we investigate the optical properties of large-scale, ordered silver-coated polystyrene microspheres films fabricated on glass substrate using convective self-assembly (CSA) method, with goal their application as active plasmonic for Surface-Enhanced Raman Spectroscopy (SERS). We film an optimized CSA protocol a custom-built equipment. Scanning electron microscopy (SEM) reveals close-packed large area monolayer intact microspheres. The were characterized experimentally...
At present, multifunctional noble metal-based nanocomposites are extensively investigated for their potential in performing cellular imaging, diagnostics, and therapy by integration of unique plasmonic properties with the spectroscopic expression therapeutic activity appropriate drug. In this work, we report fabrication 3-dimensional (3-D) close-packed nanoassemblies gold nanoparticles controlling aggregation individual solution subsequent stabilization formed aggregates Pluronic block...
This paper presents the fabrication and characterization of new gold-silver core-shell nanoparticles labeled with para-mercaptobenzoic acid (4MBA) molecules demonstrates their use as surface-enhanced Raman spectroscopy (SERS)-nanotags ultra-bright traceability inside cells ability to convey spectrally-coded information about intracellular pH by means SERS. Unlike previous reported studies, our procedure includes in first step synthesis chitosan-coated gold a seed material subsequent growing...
The ability to provide large electric field enhancements renders triangular nanoprisms and branched nanoparticles very attractive for applications in surface-enhanced Raman spectroscopy (SERS). Theoretical studies on the optical properties of prisms a water solution are presented this paper determine how structural modifications incident polarization affect extinction spectrum enhanced local fields (E-field) around particles wavelength range 300–1000 nm. near-field properties, such as...