A5047367672- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Biosensors and Analytical Detection
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Plasmonic and Surface Plasmon Research
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nonlinear Optical Materials Studies
- Synthesis and Reactivity of Heterocycles
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Air Quality Monitoring and Forecasting
- Photochemistry and Electron Transfer Studies
- Laser-Ablation Synthesis of Nanoparticles
- Synthesis and Characterization of Heterocyclic Compounds
- Photoacoustic and Ultrasonic Imaging
- Forensic Fingerprint Detection Methods
- Protein Interaction Studies and Fluorescence Analysis
- Bone Tissue Engineering Materials
- Microfluidic and Bio-sensing Technologies
Babeș-Bolyai University
2016-2025
Bolyai Foundation
2021
Spitalul Clinic Județean de Urgență Cluj-Napoca
2016-2017
Abstract Early medical diagnostic in nanomedicine requires the implementation of innovative nanosensors with highly sensitive, selective, and reliable biomarker detection abilities. In this paper, a dual Localized Surface Plasmon Resonance - Enhanced Raman Scattering (LSPR- SERS) immunosensor based on flexible three-dimensional (3D) gold (Au) nanocups platform has been implemented for first time to operate as relevant “proof-of-concept” specific antigen-antibody binding events, using human...
In this Research Article, we propose a new class of contrast agents for the detection and multimodal imaging CD19(+) cancer lymphoblasts. The are based on NIR responsive hollow gold-silver nanospheres conjugated with antiCD19 monoclonal antibodies marked Nile Blue (NB) SERS active molecules (HNS-NB-PEG-antiCD19). Proof concept experiments specificity complex investigated cells was achieved by transmission electron microscopy (TEM). microspectroscopic investigations via dark field (DF),...
In this work, we demonstrate the feasibility of gold bipyramidal-shaped nanoparticles (AuBPs) to be used as active plasmonic nanoplatforms for detection biotin–streptavidin interaction in aqueous solution via both Localized Surface Plasmon Resonance and Enhanced Raman Scattering (LSPR/SERS). Our proof concept exploits precise attachment recognition element at tips AuBPs, where electromagnetic field is stronger, which beneficial surface sensitivity longitudinal LSPR on local refractive index...
This study presents two new hybrid nanosystems (G-PMA(1:1)@AuBPs, G-PMA(1:3)@AuBPs), constructed from amine graphene (G-NH2) functionalized with poly(methacrylic acid) (PMA) and gold nanoparticles a bipyramidal shape (AuBPs). The nanoplatforms behave...
Abstract In this work, we investigate the optical properties of large-scale, ordered silver-coated polystyrene microspheres films fabricated on glass substrate using convective self-assembly (CSA) method, with goal their application as active plasmonic for Surface-Enhanced Raman Spectroscopy (SERS). We film an optimized CSA protocol a custom-built equipment. Scanning electron microscopy (SEM) reveals close-packed large area monolayer intact microspheres. The were characterized experimentally...
New photoluminescent carbon dots with intriguing properties were prepared from carboxylated nanoparticles <italic>via</italic> covalent bonding of <italic>p</italic>-phenylenediamine oligomers.
There is still a lack of available techniques to follow noninvasively the intracellular processes as well track or disentangle various signals from therapeutic agents at site action in target cells. We present here assessment kinetics doxorubicin (DOX) and gold nanoparticle (AuNP) carriers by mapping simultaneously fluorescence photoluminescence lifetime imaging microscopy under two-photon excitation (TPE-FLIM). The new nano–chemotherapeutic system AuNPs@gelatin–hyd–DOX has been fabricated...
Ovarian cancer is a common cause of death in women and associated with the highest mortality rates all gynecological malignancies. Carboplatin (CBP) most used cytotoxic agent treatment ovarian cancer. Herein, we design assess CBP nanotherapeutic delivery system which allows combinatorial functionalities chemotherapy, pH sensing, multimodal traceable properties inside live NIH:OVCAR-3 cells. In our design, pH-sensitive Raman reporter, 4-mercaptobenzoic acid (4MBA) anchored onto surface...
We report on the nonlinear photochemistry fabrication of three-dimensional silver (Ag) microstructures in microfluidic channels for volumetric surface-enhanced Raman scattering (3D SERS). The high resolution 3D Ag is obtained by a two-photon induced reduction process cations, which restricted at focal point Q-switched Nd:YAG microlaser (sub-nanosecond pulses 1064 nm). Firstly, micro-pillars made cover glass showed SERS detection limit Oxazine 720 as low 10−8 M. Secondly, we directly...
In this work, we present a thorough study on the evaluation of photothermal conversion efficiencies gold nanobipyramids (AuBPs) under irradiation by two phototherapeutic laser lines at 785 and 808 nm. Due to fine tunability longitudinal localized surface plasmon resonance (LSPR) AuBPs along entire biological window, have great potential be applied as efficient agents in specific hyperthermia applications. Aiming identify most suitable for each line, here synthetized six different aspect...
Novel (N-arylamino)phenothiazinium dyes containing meta-substituted-arylamine auxochrome units were successfully obtained by applying a sonochemical protocol designed for more efficient energy usage in the preparation of methylene blue (MB) analogues. Single crystal X-ray diffraction analysis revealed spatial arrangement aggregated crystalline state (N-(meta-bromoaryl)amino)phenothiazinium dye with minor variances induced nature halogenide counterion (iodide or chloride). The optical UV-vis...
Healing and charge transfer effects at chemically derived graphene interfaces revealed through correlative Raman two-photon fluorescence lifetime imaging.
The implementation of metal enhanced fluorescence (MEF) as an efficient detection tool, especially in the near-infrared region electromagnetic spectrum, is a rather new direction for diagnostic analytical technologies. In this context, we propose novel microfluidic plasmonic design based on paper MEF "proof-of-concept" biotin–streptavidin recognition interaction. Our made use benefits gold nanobipyramids (AuBPs), considering strong field present at their sharp tips, and filter to operate...
In this work, we design new plasmonic paper-based nanoplatforms with interesting capabilities in terms of sensitivity, efficiency and reproducibility for promoting multimodal biodetection via Localized Surface Plasmon Resonance (LSPR), Enhanced Raman Spectroscopy (SERS) Metal Fluorescence (MEF). To succeed, exploit the unique optical properties gold nanobipyramids (AuBPs) deposited onto cellulose fibers calligraphy using a commercial pen. The first step biosensing protocol was to precisely...