A5007829705- Connexins and lens biology
- Synthesis and biological activity
- Extracellular vesicles in disease
- Protein Tyrosine Phosphatases
- Crystal structures of chemical compounds
- Bioactive Compounds and Antitumor Agents
- Biochemical Acid Research Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Proteoglycans and glycosaminoglycans research
- Nanoparticle-Based Drug Delivery
- Galectins and Cancer Biology
- Ion Channels and Receptors
- Synthesis of heterocyclic compounds
- Hippo pathway signaling and YAP/TAZ
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Biotin and Related Studies
- RNA Interference and Gene Delivery
- Alcoholism and Thiamine Deficiency
- Phytochemicals and Antioxidant Activities
- Protein Kinase Regulation and GTPase Signaling
- Synthesis and Biological Evaluation
- Redox biology and oxidative stress
- Metabolism and Genetic Disorders
Institute of Biochemistry
2016-2023
Romanian Academy
2014-2021
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs stabilized with Polyethylene glycol (PEG) and loaded doxorubicin (DOX). Small were efficiently enriched from melanoma cells cultured under metabolic stress by ultrafiltration coupled size exclusion chromatography (UF-SEC) characterized size,...
Abstract Eyes absent (EYA) proteins are unusual combining in a single polypeptide chain transactivation, threonine phosphatase, and tyrosine phosphatase activities. They play pivotal roles organogenesis involved variety of physiological pathological processes including innate immunity, DNA damage repair or cancer metastasis. The molecular targets EYA activity still elusive. Therefore, we sought to identify novel substrates also obtain further insight into the tyrosine-dephosphorylating role...
Abstract The transient receptor potential melastatin type 8 (TRPM8) channel is expressed in primary afferent neurons where it the main transducer of innocuous cold temperatures and also a variety tumors, involved progression metastasis. Modulation this by intracellular signaling pathways has therefore important clinical implications. We investigated modulation recombinant natively TRPM8 Src kinase, which known to be cancer pathophysiology inflammation. Human HEK293T cells constitutively...
Affibody linked to a rigid macrocyclic chelator derived form pyclen-3,9-diacetate (3,9-PC2A) labelled with [ 52 Mn]Mn isotope appears be valuable tool for PET-based targeted molecular imaging.
Eyes absent (EYA) are non-thiol-based protein tyrosine phosphatases (PTPs) that also have transcriptional co-activator functions. Their PTP activity is involved in various pathologies. Recently, we demonstrated Src kinase phosphorylates human EYA3 by controlling its subcellular localization. We found EYA3's ability to autodephosphorylate, while raising the question if two opposing processes could be maintaining a physiologically adequate level of phosphorylation. Using native and bottom-up...
In the present study, new 1,2,4-triazoles, 1,3,4-thiadiazoles, and acylthiosemicarbaz-ides derived from 4-(4-chlorophenylsulfonyl)benzoic acid hydrazide were synthesized screened for their antimicrobial analgesic activities. Acylthiosemicarbazides 2–4 by a reaction of 4-(4-chlorophenyl-sulfonyl)benzoic 1 with different arylisothiocyanates.4,5-Disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones 5–7 2,5-disubstituted-1,3,4-thiadiazoles 8–10 obtained dehydrative cyclization corresponding...
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, based on EVs stabilized with Polyethylene glycol (PEG) and loaded doxorubicin (DOX). Nanosized were efficiently enriched from melanoma cells cultured under metabolic stress by ultrafiltration coupled size exclusion chromatography (UF-SEC) characterized size,...
Abstract All compounds were screened for their antimicrobial and analgesic activities.
Abstract β,β‐Dimethylacrylsäure wird durch Oxidation von Mesityloxid mit wäßriger Natrium‐hypochloritlösung (Molverhältnis 1:4) in Gegenwart Triethyl‐alkyl‐ammoniumchlorid als Phasentransferkatalysator einer Ausbeute 60% erhalten.