A5082803202- Bone Tissue Engineering Materials
- Dental materials and restorations
- Blood properties and coagulation
- Laser-Ablation Synthesis of Nanoparticles
- 3D Printing in Biomedical Research
- Erythrocyte Function and Pathophysiology
- Laser Applications in Dentistry and Medicine
- Orthopaedic implants and arthroplasty
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Dental Implant Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Nonlinear Optical Materials Studies
- Pancreatic function and diabetes
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Mesenchymal stem cell research
- Laser Material Processing Techniques
- Surface Modification and Superhydrophobicity
- Laser-Plasma Interactions and Diagnostics
- Lysosomal Storage Disorders Research
- Autophagy in Disease and Therapy
Institute of Biochemistry
2016-2025
Romanian Academy
2016-2025
Northwestern University
2017-2025
Midwestern University
2018-2020
University of Bucharest
2010
Universitatea Națională de Știință și Tehnologie Politehnica București
2010
Institutul de Chimie Macromoleculară Petru Poni
2010
National Institute for Laser Plasma and Radiation Physics
2010
Synthesis of nanostructured thin films pure and oxidized levan exopolysaccharide by matrix-assisted pulsed laser evaporation is reported. Solutions exopolysaccharides in dimethyl sulfoxide were frozen liquid nitrogen to obtain solid cryogenic pellets that have been used as targets experiments with a KrF* excimer source. The expulsed material was collected assembled onto glass slides Si wafers. contact angle studies evidenced higher hydrophilic behavior the case structures because presence...
Cancer progression and recurrence are linked to a rare population of cancer stem cells (CSC). Here, we hypothesized that interactions with the extracellular matrix drive CSC proliferation tumor-initiating capacity investigated functions scaffold protein tissue transglutaminase (TG2) in ovarian CSC. Complexes formed by TG2, fibronectin (FN), integrin β1 were enriched detectable tumors. A function-inhibiting antibody against TG2 FN-binding domain suppressed complex formation, as spheroids,...
In this study, we report on the synthesis of L-Cysteine (L-Cys)-coated magnetic iron oxide nanoparticles (NPs) loaded with doxorubicin (Dox). The Fe3O4-L-Cys-Dox NPs were extensively characterized for their compositional and morpho-structural features using EDS, SAED, XRD, FTIR TEM. XPS, Mӧssbauer spectroscopy SQUID measurements also performed to determine electronic properties nanoparticles. Moreover, by means a FO-SPR sensor, evidenced confirmed binding Dox L-Cys. Biological tests mouse...
Abstract In this work, an improved version of the radio frequency magnetron sputtering (RF‐MS) technique was used to prepare highly adherent B‐type carbonated hydroxylapatite (B‐CHA) thin films. Fourier transform infrared spectroscopy (FTIR) and grazing incidence X‐ray diffraction studies proved that coatings maintained composition revealed polycrystalline structure HA. Scanning electron microscopy analysis showed CHA films are rough exhibit a homogeneous microstructure. Energy‐dispersive...
Abstract Introduction Human Wharton’s jelly (WJ) has become a preferred source of mesenchymal stem cells (MSCs) whose clinical applications are limited by the use adequate xeno-free (XF), in vitro manipulation conditions. Therefore, objective our study was to characterize WJ-derived MSCs (WJ-MSCs), isolated different methods and cultured commercially available, MSC XF medium, not least all investigating their endothelial differentiation capacity. Methods WJ explants enzymatically dissociated...
In response to DNA-damaging physical or chemical agents, the DNA damage repair (DDR) pathway is activated in eukaryotic cells. radiobiology field, it important assess effect of a certain irradiation regime on cancer cells and compare non-transformed exposed identical conditions. The first step mechanism consists attachment proteins such as phosphorylated histone γ-H2AX (p-γ-H2AX) double-strand breaks (DSB) nucleus, which leads formation repairing foci. Therefore, imaging methods were...
Abstract Background Chronic hepatitis B virus (HBV) infection is a major risk for development of hepatocellular carcinoma (HCC), frequent malignancy with poor survival rate. HBV results in significant endoplasmic reticulum (ER) stress and activation the unfolded protein response (UPR) signaling, contributing factor to carcinogenesis. As part UPR, ER - associated degradation (ERAD) pathway responsible removing burden misfolded secretory proteins, re establish cellular homeostasis. Emerging...
Tissue transglutaminase (TG2) is a multifunctional protein with roles in multiple diseases including cancer. It was found overexpressed many solid tumors the past two decades. In ovarian cancer, it emerged as potential therapeutic target due to its involvement processes like metastasis and chemo- radiotherapy resistance. Generally, TG2 expression cancer cells has been extensively studied linked increased tumor progression. However, role host less studied. Our research explored anti-tumor...
There is increased interest in smart bioactive materials to control tissue regeneration for the engineering of cell instructive scaffolds. We introduced combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) as a new method fabrication organic thin films with compositional gradient. Synchronized C-MAPLE levan and oxidized was employed assemble two-compound biopolymer film structure. The gradient composition validated by fluorescence microscopy. In this study, we investigated...
Our study focused on the long-term degradation under simulated conditions of coatings based different compositions polycaprolactone-polyethylene glycol blends (PCL-blend-PEG), fabricated for titanium implants by a dip-coating technique. The behavior polymeric was evaluated polymer mass loss measurements PCL-blend-PEG during immersion in SBF up to 16 weeks and correlated with those yielded from electrochemical experiments. results are thoroughly supported extensive compositional surface...
We introduce a combinatorial approach for the fabrication of organic biopolymer thin films. Structures with compositional gradient are obtained by simultaneous laser vaporization two distinct targets. Matrix-assisted pulsed evaporation deposition method was applied to obtain library levan and oxidized in form film. The film composition structure demonstrated infrared spectroscopy while vitro cell culture assays illustrated characteristic responses cells specific surface regions. can rapidly...
In this work, we report the synthesis of functional biocompatible piezoelectric (1 – x)Ba(Ti0.8Zr0.2)TiO3–x(Ba0.7Ca0.3)TiO3, x = 0.45 (BCZT45), thin films with high properties. Pulsed-laser-based techniques, classical pulsed-laser deposition and matrix-assisted evaporation, were used to synthesize BCZT45 films. The second technique was employed in order ensure growth on polymer flexible Kapton substrates. grown by both techniques show similar structural properties coefficient coupling...
Since Graphene discovery, their associated derivate nanomaterials, Oxide (GO) and reduced-GO were in the forefront of continuous developments bio-nano-technology due to unique physical-chemical properties. Although GO nano-colloids (GON) proposed as drug release matrix for targeting cancer cells, there is still a concern regarding its cytotoxicity issues. In this study, we report on fabrication functional GON bio-coatings by Matrix-Assisted Pulsed Laser Evaporation (MAPLE) be used carriers...