Lyophilization is used to ensure an increased shelf-life of liposomes, by preserving them in dry state, more stable than the aqueous dispersions. When stored as systems, encapsulated drugs are released and liposomes might aggregate or fuse. The aim this study was develop optimize a lyophilized formulation simvastatin (SIM) loaded into long circulating using Quality Design (QbD) approach. Pharmaceutical development QbD aims identify characteristics that critical for final product quality,...

Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence research efforts directed toward the development personalized dosage forms. In addition to customization in terms shapes, sizes, or delivered drug doses, modulation release profiles crucial ensure superior efficacy and safety modern 3D-printed medications compared those conventional ones. Our work aims solidify groundwork for preparation tablets that sustained...

This study proposed the development of oral lyophilisates with respect to pediatric medicine guidelines, by applying risk management strategies and DoE as an integrated QbD approach.Product critical quality attributes were overviewed generating Ishikawa diagrams for assessment purposes, considering process, formulation methodology related parameters. Failure Mode Effect Analysis was applied highlight process parameters increased probability occurrence a high impact on product performance. To...

Three-dimensional printing (3DP) by fused deposition modeling (FDM) has gained momentum as a promising pharmaceutical manufacturing method due to encouraging forward-looking perspectives in personalized medicine preparation. The current challenges the technology for applicability fabrication of solid dosage forms include limited range suitable grade thermoplastic materials. Hence, it is important investigate implications variable properties polymeric carrier on preparation steps and final...

This work focused on simultaneously investigating formulation variables and freeze-drying parameters when preparing orodispersible tablets with meloxicam (Mel), by a Quality Design (QbD) approach.Methylcellulose (MC) was selected as matrix forming agent mannitol (Man) cryoprotectant, both at two concentration levels. The freezing regime also varied between fast shelf-ramped, to find out how it affects the final products. tablet formulations were characterized for their disintegration time,...

This study highlights the advantages of using a Quality by Design (QbD) approach in order to gain more comprehensive understanding freeze-drying process pravastatin-loaded long-circulating liposomes (LCL-PRAV). Within QbD paradigm, present aimed establish design space for optimization freeze-dried LCL-PRAV means Experiment (DOE). The encapsulated solute retention (ESR), average particle size, and zeta potential after freeze-drying, residual moisture content, macroscopic cake appearance,...

Colorectal cancer remains one of the major causes morbidity and mortality in both developed emerging countries. Cancer stem cells (CSCs) are a subpopulation within tumor mass harboring cell characteristics, considered responsible for initiation, growth, relapse, treatment failure. Lately, it has become clear that CSCs non-CSCs have to be eliminated successful eradication cancer. Drug delivery systems been extensively employed enhance drug efficacy. In this study, salinomycin (SAL), selective...

Salt formation is a good method of increasing solubility, dissolution rate and consequently the bioavailability poor soluble acidic or basic drugs [Polymorphism in Pharmaceutical Solids, Drugs Sciences, Vol. 192, 2nd edn, Informa Healthcare, New York, 2009]. The aim this study was to obtain investigate structural properties compound obtained by solvent drop grinding (SDG) [Chem. Commun. (Camb.) 20 (2002), 2372–2373] at room temperature starting from 1:1 molar ratios ambazone (AMB) niflumic...

The purpose of this study was to highlight the way in which thermoanalytical and complementary techniques can guide development meloxicam oral lyophilisates both preformulation formulation stages, as well for final products characterization.Thermoanalytical methods (differential scanning calorimetry -DSC, thermogravimetry -TGA) (Fourier transform infrared -FTIR, X-Ray powder diffraction -XRPD, electron microscopy -SEM) were applied order obtain a complete set data.In stage, compatibility...

Objectives. Design of Experiments (DOE) is a powerful tool for identifying important formulation factors and processparameters in drug design manufacturing, to ensure certain product specifications.This study aimed at manufacturing curcumin-loaded polycaprolactone nanoparticles (CURC-PCL NP), used DOE order understand how process variables impact the delivery system's characteristics.Polymeric are suitable approach incorporating hydrophobic drugs such as curcumin, maximize numerous...

We investigate the mediating role of psychological safety in relationship between leaders' coaching behavior and health professionals' willingness to acknowledge analyze errors medical units. used SEM test mediated effect. Results indicate both a direct an indirect effect leadership on collective learning behaviors. Our data suggest that capitalizing past mistakes order improve patient quality care depends interpersonal skills leaders field group climate they facilitate.

Meloxicam, a widely recommended AINS, presents poor water solubility, which limits its bioavailability and effect onset. The objective of this study is the investigation most important factors that influence efficiency sonication in preparation meloxicam nanocrystals.The effects crucial technological parameters (amplitude, time applied cycle) on crystal sizes dissolution were investigated using central composite experimental design with three levels. Different mathematical models for...

The development of suitable formulations for the pediatric population remains a challenging field with great advances reported every year in terms excipients and technology. When developing formulations, acceptability medicines represents key element to consider. For this reason, milk can be widely accepted excipient taste-masking properties supplementary advantages drug solubility. In recent years, orodispersible dosage forms have come onto market as child-friendly formulations. current...

Salt formation is a good method of increasing solubility, dissolution rate and consequently the bioavailability poor soluble acidic or basic drugs (Polymorphism in Pharmaceutical Solids, Drugs Sciences, Vol. 192, 2nd edn, Informa Healthcare, New York, 2009). The aim this study was to obtain investigate structural properties compound obtained by solvent drop grinding (SDG) (Chem. Commun. (Camb.) 20 (2002), 2372-2373) at room temperature starting from 1:1 molar ratios ambazone (AMB) niflumic...

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Lucia M. Rus, Irina Kacso, Gheorghe Borodi, Mihaela Aluas, Ioan Tomuta, Cristina Iuga, Simion Simon, Bratu, Marius Bojita; Solid form of indapamide recrystallized from acetonitrile/diethyl ether solvent mixture. AIP Conference Proceedings 8 February 2012; 1425 (1): 39–42. https://doi.org/10.1063/1.3681961...

This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment water soluble base -polyethylene glycol (PEG).Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine compatibility between active ingredients (APIs) APIs -excipients.Nine formulations (F1 -F9) tested for: physical appearance homogeneity, pH, viscosity osmotic activity.The optimal formulation...

A HPLC-UV method, for determination of dextromethorphan hydrobromide in syrup, was validated. The chromatographic analysis performed using an RP-18, Nucleodur column (250 mm � 4 mm, 5 �m) at constant temperature (50oC) with a mobile phase consisting mixture acetonitrile/methanol (70:30 v/v) sodium docusate (as ion pair agent) and ammonium nitrate, pH = 3.4. flow rate the 1 mL/min detection carried out 280 nm. System suitability, specificity, linearity, precision, accuracy, limit...