A5059278513- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- 3D Printing in Biomedical Research
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Analytical Chemistry and Chromatography
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmaceutical studies and practices
- Polymer crystallization and properties
- Bone health and treatments
- Nanofabrication and Lithography Techniques
- Polysaccharides Composition and Applications
- Protein purification and stability
- Crystallization and Solubility Studies
- Mineral Processing and Grinding
- Dendrimers and Hyperbranched Polymers
- Anesthesia and Pain Management
- Injection Molding Process and Properties
- Advancements in Transdermal Drug Delivery
- Inflammatory mediators and NSAID effects
- Microencapsulation and Drying Processes
- Ocular Surface and Contact Lens
- Hydrogels: synthesis, properties, applications
Iuliu Hațieganu University of Medicine and Pharmacy
2009-2024
Three-dimensional (3D) printing in the pharmaceutical field allows rapid manufacturing of a diverse range dosage forms, including personalized items. The application this technology form requires judicious selection excipients because selected materials must be appropriate to working principle each technique. Most techniques rely on use polymers as main material. Among pharmaceutically approved polymers, polyvinyl alcohol (PVA) is one most used, especially for fused deposition modeling (FDM)...
Gastroretentive drug delivery systems (GRDDSs) have gained substantial attention in the last 20 years due to their ability retain stomach for an extended time, thus promoting release and high bioavailability a broad range of active pharmaceutical ingredients (APIs) that are pH-sensitive and/or narrow absorption window. The currently existing GRDDSs include floating, expanding, mucoadhesive, magnetic, raft-forming, ion-exchanging, high-density systems. Although there seven types systems, main...
Context: Near-Infrared (NIR) spectroscopy is an important component of a Process Analytical Technology (PAT) toolbox and key technology for enabling the rapid analysis pharmaceutical tablets.Objective: The aim this research work was to develop validate NIR-chemometric methods not only determination active ingredients content but also properties (crushing strength, disintegration time) meloxicam tablets.Materials methods: development method assay performed on samples corresponding 80%, 90%,...
The aim of this study was to develop a suitable clotrimazole (CLT)-loaded mucoadhesive vaginal gel (CLT-MVG) for topical applications in candidiasis. Ten CLT-MVG formulations were prepared, consisting mixtures acid polyacrylic (Carbopol 940) and polyethene oxides, Sentry Polyox WSRN 1105 or 750, according an experimental D-optimal design, CLT suspended at ratio 1%. prepared studied vitro, the formulation containing Carbopol 940 0.89% combined with PEO 1.39% identified optimal rheological...
Orodispersible tablets (ODTs) represent a growing category of dosage forms intended to increase the treatment acceptability for special groups patients. ODTs are designed rapidly disintegrate in oral cavity and be administered without water. In addition, easy manufacture using standard excipients pharmaceutical equipment. This study adds previously published research that developed an instrumental tool predict disintegration texture-related palatability with different formulations. The...
In recent years, solid dosage forms have gained interest in pediatric therapy because they can provide valuable benefits terms of dose accuracy and stability. Particularly for orodispersible films (ODFs), the literature evidences increased acceptability flexibility. Among various available technologies obtaining ODFs, such as solvent casting, hot-melt extrusion, ink printing technologies, solvent-free preparation methods exhibit significant advantages. This study investigated Vacuum...
A near infrared (NIR) method able to directly quantify the active content in pharmaceutical powder blends used for manufacturing meloxicam tablets, without any sample preparation, was developed and fully validated. To develop calibration models assay of tableting, NIR reflectance spectra different prepared according a protocol analysed using pre-processing methods by partial last-square regression (PLS) principal component (PCR). The best model found when as algorithm association with...
Coupling hot melt extrusion (HME) with 3D printing (3DP) through fused deposition modelling (FDM) allows today the manufacturing of oral solid dosage forms desired characteristics, suitable for personalized medicine.Among advantages applying this combination technologies in forms, one is that it enhances solubility and bioavailability poorly water-soluble compounds.In context, our work aimed at preparation prolonged-release containing felodipine, chosen as drug BCS class II, by coupling HME...
The aim of this study was to formulate and prepare compression-coated tablets for colonic release (CR-tablets), evaluate the bioavailability ketoprofen following administration a single dose from mini-tablets with immediate (IR-tablets) compared CR-tablets. CR-tablets were prepared based on time-controlled hydroxypropylmethylcellulose K100M inner compression-coating pH-sensitive Eudragit® L 30D-55 outer film-coating. clinical consisted two periods, in which formulations administered 6...
Objectives.The aim of this study was to investigate the influence in vitro release test parameters on ibuprofen from sustained inert matrix tablets.Materials and methods.Ibuprofen tablets were manufactured at a laboratory scale using Kollidon ® SR as formator.The variables were: dissolution media pH (7.2-6.8-5.4-1.2),apparatus type (rotative basket rotative paddle) stirring speed (50 rpm 100 rpm).Outcomes.An increase solubility together with an value observed.Percentage drug increases...
Objectives. The aim of this study was to investigate the influence formulation factors on in vitro release ketoprofen from sustained inert matrix tablets. Materials and methods. Laboratory scale, Ketoprofen tablets were manufactured using Kollidon® SR as formator, by direct tableting powder blends. (X1 – formator excipient X2 diluent type) studied a full factorial 23 experimental plan. Outcomes. Pharmacotechnical characterization laboratory scale batches performed all 12 fulfilled European...
Felodipine is a dihydropyridine calcium antagonist that presents good characteristics to be formulated as prolonged release preparations. The aim of the study was formulation and in vitro characterization reservoir type system with felodipine, over 12 hours period using Simplex method.The first step method influence granules coating on felodipine release. Furthermore polymer type, percent pore forming agent were studied. Afterwards these two steps experimental design Surelease applied loaded...
The purpose of this research was to apply near-infrared (NIR) spectroscopy in combination with chemometrics predict particle size and flow characteristics a meloxicam powder blends for tableting. In order develop calibration models (mean size, poly-dispersion index), properties (angle repose time flow) prediction, the NIR reflection spectra different prepared according an experimental design were analyzed using preprocessing methods by partial last-square (PLS) regression followed...