A5023510376- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Protein purification and stability
- Curcumin's Biomedical Applications
- Analytical Methods in Pharmaceuticals
- Inflammatory mediators and NSAID effects
- Anesthesia and Pain Management
- Hydrogels: synthesis, properties, applications
- Polysaccharides Composition and Applications
- Microscopic Colitis
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Pharmaceutical studies and practices
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Inflammatory Bowel Disease
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- Inhalation and Respiratory Drug Delivery
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2024
Babeș-Bolyai University
2015
The purpose of this study was to apply the quality-by-design (QbD) approach for development colon-targeted curcumin-loaded polymeric microparticles (Col-CUR-MPs). proportion enterosoluble polymer (Eudragit® FS) in matrix, curcumin concentration, and concentration mixture FS-polycaprolactone) were identified as potential risk factors quality final product following assessment. influence these variables on critical attributes (CQAs) Col-CUR-MPs investigated. Therefore, a central composite face...
Curcumin's role in the treatment of ulcerative colitis (UC) has been proven by numerous studies, but its preventive administration, with aim reducing remission episodes that are characteristic this disease, must be further investigated. This study investigates effects a novel curcumin-loaded polymeric microparticulate oral-drug-delivery system for colon targeting (Col-CUR-MPs) an experimental model UC. Male Wistar rats (n = 40) were divided into five groups 8), which treated daily oral...
Orodispersible tablets (ODTs) represent a growing category of dosage forms intended to increase the treatment acceptability for special groups patients. ODTs are designed rapidly disintegrate in oral cavity and be administered without water. In addition, easy manufacture using standard excipients pharmaceutical equipment. This study adds previously published research that developed an instrumental tool predict disintegration texture-related palatability with different formulations. The...
In recent years, solid dosage forms have gained interest in pediatric therapy because they can provide valuable benefits terms of dose accuracy and stability. Particularly for orodispersible films (ODFs), the literature evidences increased acceptability flexibility. Among various available technologies obtaining ODFs, such as solvent casting, hot-melt extrusion, ink printing technologies, solvent-free preparation methods exhibit significant advantages. This study investigated Vacuum...
Abstract The success of efficiently delivering genetic material to target cells depends on developing an appropriate vector. Among the variety nanocarriers used for gene therapy, cationic liposomes are most investigated in different forms cancer. Cationic contain lipids with positively charged head groups that form electrostatic bonds negatively phosphate group nucleic acids, ensuring efficient loading material. aim this study was development and vitro characterization liposomal formulations...
Recent studies have shown that low molecular weight heparins are effective in the treatment of inflammatory bowel disease. Therefore, there is considerable interest development an oral colonic delivery pharmaceutical system allowing targeted release heparin inflamed tissue. The objective this study was to prepare microparticles for administration and enoxaparin evaluate influence certain formulation factors on their characteristics.Microparticles were prepared by water/oil/water double...
The aim of this study was to formulate and prepare compression-coated tablets for colonic release (CR-tablets), evaluate the bioavailability ketoprofen following administration a single dose from mini-tablets with immediate (IR-tablets) compared CR-tablets. CR-tablets were prepared based on time-controlled hydroxypropylmethylcellulose K100M inner compression-coating pH-sensitive Eudragit® L 30D-55 outer film-coating. clinical consisted two periods, in which formulations administered 6...
Objectives.The objective of this study was to investigate the possibility developing metoprolol extended-release tablets by using hydroxypropyl methylcellulose (HPMC) in order obtain hydrophilic matrix and Eudragit NE 40D, Kollicoat SR 30D Surelease E7 as binders during granulation process.Material methods.The were prepared via fluid bed powder 40D / binders, followed compression.The influence three formulation factors (the type polymers, ratio polymers HPMC ratio) on kinetic tartrate...