A5074925623- Drug Solubulity and Delivery Systems
- Pharmaceutical studies and practices
- 3D Printing in Biomedical Research
- Protein purification and stability
- Advanced Drug Delivery Systems
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Chromatography
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microencapsulation and Drying Processes
- Child Nutrition and Feeding Issues
- Pediatric Pain Management Techniques
- Oral Health Pathology and Treatment
- Antimicrobial agents and applications
- Biochemical Analysis and Sensing Techniques
- Wound Healing and Treatments
- Analytical Methods in Pharmaceuticals
- Oral microbiology and periodontitis research
- Phytochemicals and Antioxidant Activities
- Childhood Cancer Survivors' Quality of Life
- Anesthesia and Pain Management
- Injection Molding Process and Properties
- Granular flow and fluidized beds
- Polysaccharides Composition and Applications
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2024
Three-dimensional (3D) printing in the pharmaceutical field allows rapid manufacturing of a diverse range dosage forms, including personalized items. The application this technology form requires judicious selection excipients because selected materials must be appropriate to working principle each technique. Most techniques rely on use polymers as main material. Among pharmaceutically approved polymers, polyvinyl alcohol (PVA) is one most used, especially for fused deposition modeling (FDM)...
Winery industry by-products have a great reuse potential in the pharmaceutical and cosmetic fields due to their bioactive compounds. This study investigates phytochemical profile bioactivity of Vitis vinifera variety Fetească neagră tendrils extract (TE) leaves (LE), intended be used oral hygiene products recommended periodontal disease. The evaluation phenolic content was performed by colorimetric analysis. Liquid chromatography coupled with mass spectrometry determine chemical two extracts...
Gastroretentive drug delivery systems (GRDDSs) have gained substantial attention in the last 20 years due to their ability retain stomach for an extended time, thus promoting release and high bioavailability a broad range of active pharmaceutical ingredients (APIs) that are pH-sensitive and/or narrow absorption window. The currently existing GRDDSs include floating, expanding, mucoadhesive, magnetic, raft-forming, ion-exchanging, high-density systems. Although there seven types systems, main...
Abstract: Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of elasticity. The aim this research was to obtain topical product containing herbal active ingredients documented antioxidant and anti-inflammatory activity ( Punica granatum seed oil Croton lechleri resin extract) demonstrate its positive effect on prevention treatment striae distensae. First, the cream base formulation optimized through experimental design. Secondly, two investigated...
The aim of the present study was to establish best experimental conditions that lead extracts richest in polyphenolic compounds obtained from pomace and canes Vitis vinifera. In this regard, a D-Optimal design experiments (DoE) method applied investigate extraction process parameters each three materials: red (RP), white (WP) (C). input variables were temperature ethanol ratio as response, total polyphenols content (TPC) determined. A space generated for plant materials most concentrated...
Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence research efforts directed toward the development personalized dosage forms. In addition to customization in terms shapes, sizes, or delivered drug doses, modulation release profiles crucial ensure superior efficacy and safety modern 3D-printed medications compared those conventional ones. Our work aims solidify groundwork for preparation tablets that sustained...
This study proposed the development of oral lyophilisates with respect to pediatric medicine guidelines, by applying risk management strategies and DoE as an integrated QbD approach.Product critical quality attributes were overviewed generating Ishikawa diagrams for assessment purposes, considering process, formulation methodology related parameters. Failure Mode Effect Analysis was applied highlight process parameters increased probability occurrence a high impact on product performance. To...
This work focused on simultaneously investigating formulation variables and freeze-drying parameters when preparing orodispersible tablets with meloxicam (Mel), by a Quality Design (QbD) approach.Methylcellulose (MC) was selected as matrix forming agent mannitol (Man) cryoprotectant, both at two concentration levels. The freezing regime also varied between fast shelf-ramped, to find out how it affects the final products. tablet formulations were characterized for their disintegration time,...
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. work aimed prove that an accurate control critical parameters can level input material variability offer user-friendly strategy. Moreover, in-line Near-Infrared monitoring method was developed, which offered real time overview moisture along process, thus reliable supervision analytical technology...
Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, mitigation input-induced variability should also consider downstream processability intermediary products. The objective present work was to study effect variable and conditions on compression properties granules containing two active pharmaceutical ingredients (APIs) microcrystalline cellulose. Differences in compressibility tabletability were highlighted function initial particle size first...
This study focuses on the development of a drug product based risk assessment-based approach, within quality by design paradigm. A prolonged release system was proposed for paliperidone (Pal) delivery, containing Kollidon® SR as an insoluble matrix agent and hydroxypropyl cellulose, methylcellulose (HPMC), or sodium carboxymethyl cellulose hydrophilic polymer. The experimental part preceded identification potential sources variability through Ishikawa diagrams, failure mode effects analysis...
The present study aimed to develop 3D printed dosage forms, using custom-made filaments loaded with diclofenac sodium (DS). tablets were developed by implementing a quality design (QbD) approach. Filaments adequate FDM printing characteristics produced via hot melt extrusion (HME). Their formulation included DS as active substance, polyvinyl alcohol (PVA) polymer, different types of plasticisers (mannitol, erythritol, isomalt, maltodextrin and PEG) superdisintegrants (crospovidone...
In this study, the biological activities of four extracts from Vitis vinifera by-products: two pomace extracts, white (WPE) and red (RPE), a canes extract (CE), their combination (CoE), were evaluated, to be included in freeze-drying mouthwashes formulations. The cytocompatibility anticancerous potential tested on three cancerous cell lines, as well cytoprotective activity against nicotine-induced cytotoxicity antioxidant determined human gingival fibroblasts (HGF) line. Additionally,...
The aim of the present study was to evaluate funtion fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. FSM isolated and characterized. colloidal dispersions were prepared rheological evaluation performed. Oral lyophilisates (OLs) with different concentrations, containing meloxicam model drug by freeze drying method. OLs characterized compared gelatin tablets, under same conditions. revealed shear thinning flow type. Based on...