A5000504875- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmacovigilance and Adverse Drug Reactions
- Biochemical effects in animals
- Pharmaceutical studies and practices
- Advanced Drug Delivery Systems
- Skin Protection and Aging
- Advanced Chemical Sensor Technologies
- Diabetes Treatment and Management
- Sensory Analysis and Statistical Methods
- Spectroscopy and Chemometric Analyses
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Antibiotic Use and Resistance
- HER2/EGFR in Cancer Research
- Antimicrobial Resistance in Staphylococcus
- Bee Products Chemical Analysis
- Coenzyme Q10 studies and effects
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Facial Trauma and Fracture Management
- Facial Rejuvenation and Surgery Techniques
- Respiratory and Cough-Related Research
Lucian Blaga University of Sibiu
2019-2024
Transylvania University of Brașov
2012
Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe clinical characteristics, outcomes, and relationship between antibiotic exposure infection (CDI) in patients based on reports from two databases. Thus, conducted retrospective study of diagnosed with CDI Sibiu County Clinical Emergency Hospital (SCCEH), Romania, followed by descriptive analysis spontaneous submitted...
Trastuzumab (T) and tyrosine kinase inhibitors (TKIs) are among the first-line treatments recommended for HER2-positive breast cancer. More recently, antibody-drug conjugates (ADCs) such as trastuzumab deruxtecan (T-DXd) emtansine (T-DM1) have been authorized, they represent second-line therapy in this type of The present study aimed to evaluate adverse drug reactions (ADRs) associated with T-based ADCs that were spontaneously reported EudraVigilance—the European pharmacovigilance database....
Antimicrobial resistance is considered one of the major threats to public health and an important factor that influences patient's outcome in intensive care unit. Pharmacovigilance can help raise awareness potential drug (DR) or ineffectiveness (DI) through adverse reaction reports are submitted different spontaneous reporting systems. Based on Individual Case Safety Reports from EudraVigilance, we conducted a descriptive analysis reactions associated with meropenem, colistin, linezolid,...
Grape pomace and berries represent natural sources of phytochemicals that can increase the quality life consumers by contributing to prevention chronic diseases; thus, development a dietary supplement was necessary. The raw material (r.m.) used for consisted dried powdered bilberries (Vaccinium myrtillus L.), red currants (Ribes rubrum fermented pomaces (Vitis vinifera L.) from Feteasca Neagra Cabernet Sauvignon cultivars. particle size distribution, powder flow, total phenolic content...
Direct oral anticoagulant drugs (DOACs) interfere with the coagulation process, thus improving patient care for those who require treatment. This study presents a descriptive analysis of adverse reactions (ADRs) attributed to DOAC dosage errors (overdose, underdose, and improper dose). The was performed based on Individual Case Safety Reports from EudraVigilance (EV) database. Results show that data reported rivaroxaban, apixaban, edoxaban, dabigatran are mostly regarding underdosing...
The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense exotoxins, contributing to nosocomial infections, and it is the most common cause of health-care-associated infectious diarrhea. Based on spontaneous Individual Case Safety Reports from EudraVigilance (EV), we conducted a descriptive analysis infection (CDI) cases that reported adverse reaction related using ceftriaxone, colistimethate, ciprofloxacin, gentamicin, linezolid, meropenem,...
The prevalence of diabetes mellitus (DM) rises constantly each year worldwide. Because that, the funds allocated for DM treatment have increased over time. Regarding number cases, Romania is among top ten countries in Europe. Based on National Diabetes Programme (NDP), antidiabetic drugs and other expenditures (Self-monitoring blood glucose (SMBG) test, HbA1c, insulin pumps/insulin pumps supplies) are free charge. This programme has undergone many changes supply, last two decades:...
Glucosinolates-rich extracts of some Brassicaceae sources, such as broccoli, cabbage, black radish, rapeseed, and cauliflower, were obtained using an eco-friendly extraction method, in a microwave field, with 70% ethanol, evaluated order to establish their vitro antioxidant activities anticorrosion effects on steel material. The DPPH method Folin-Ciocâlteu assay proved good activity (remaining DPPH, 9.54-22.03%) the content total phenolics between 1008-1713 mg GAE/L for all tested extracts....
Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treat-ment of type 2 diabetes mellitus (T2DM), have been approved for treatment obe-sity patients with or without T2DM (liraglutide – LIR, semaglutide - SEM, and tir-zepatide TIR). Social media had an important influence on off-label use GLP-1 RAs obesity, especially SEM. We analysed Google queries related to SEM assess people's interest this drug. also investigated occurrence adverse drug reactions (ADRs)...
Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treatment of type 2 diabetes mellitus (T2DM), have been approved for obesity patients with or without T2DM (liraglutide—LIR, semaglutide—SEM, and tirzepatide—TIR). Social media had an important influence on off-label use GLP-1 RAs obesity, especially SEM. We analyzed Google queries related to SEM assess people’s interest this drug. also investigated occurrence adverse drug reactions (ADRs) by searching...
Osteoarthritis (OA) is a developing process with multifactorial causality in which changes of the synovial fluid characteristics occur. Hypothesis: pH severe OA correlated other patient parameters. Synovial from 50 patients (knee/hip) was determined. The results were assessed and correlations antropologic data biological markers analyzed. (26 knee 24 hip OA) average 7.35 indicating slightly lower levels than normal joints. Higher values observed males, under 60 years, secondary OA, Rh+ Hbg...
The importance of incorporating hyaluronic acid (HA) as a cosmetic ingredient in skin care formulations emerged lately because the amount HA naturally found epidermis decreases with age, and when applied to through products, it confers hydration reduces appearance wrinkles. Currently, diversity products for mature use various innovative active ingredients supporting their anti-ageing effect represent ample proof that industry is currently relying on these actives. main objective this study...
As the most common psychiatric symptom, depression represents a subject of high interest for medical community.
The term “risk assessment” is often substituted with “safety assessment”, to demonstrate the safe properties of cosmetic ingredients and formulations. With respect actual legislative framework, proper use in silico evaluation could offer a representative non-animal substitute for toxicity ingredients. assessment needs be integrated other lines proof (in vitro and/or vivo data) form complex methodology order safety ingredients/products. present study aimed develop characterize new...
The granulation process of a metoprolol tartrate (very difficult to active pharmaceutical ingredient) formulation in laboratory scale fluid bed equipment was studied.To study the influence two factors and three parameters on characteristics granules subsequently tablets, case granulating powder mix containing tartrate.In order (binder solution concentration silicon dioxide ratio) (atomizing pressure, length final drying phase, inlet air temperature) technological properties fractional...
The aim of this study consisted in the development a rapid and reliable high performance liquid chromatography (HPLC) method for resveratrol identification assay food supplements, trying to offer robust, direct convenient solution. By method, several supplements with varying content, between 103 119% stated amount per dosage form, were analyzed.