A5052650535- Metal complexes synthesis and properties
- Phytochemistry and Biological Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Bone Tissue Engineering Materials
- Veterinary Oncology Research
- Natural product bioactivities and synthesis
- Biochemical Analysis and Sensing Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and Characterization of Heterocyclic Compounds
- Hemoglobin structure and function
- Natural Compound Pharmacology Studies
- Virus-based gene therapy research
- Phytochemicals and Antioxidant Activities
- Infectious Diseases and Mycology
- Ferrocene Chemistry and Applications
- Synthesis and biological activity
- Animal testing and alternatives
- Natural Antidiabetic Agents Studies
- Plant Parasitism and Resistance
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2016-2025
Universidade do Porto
2022
University of Agricultural Sciences, Dharwad
2009-2021
Romanian Society of Nephrology
2019
University of Veterinary Medicine
2007
This study was designed to examine the in vitro antioxidant and antimicrobial activities characterize polyphenolic composition of ethanolic extracts Hyssopus officinalis, Ocimum basilicum Teucrium chamaedrys. Qualitative quantitative analysis major phenolic compounds were conducted using high-performance liquid chromatography coupled mass spectrometry (HPLC-MS). The total polyphenols, caffeic acid derivatives flavonoids content spectrophotometrically determined. profile showed presence...
The biological properties and main phenolic compounds of the O. vulgare L. ssp. extract are described in present paper. polyphenolic were analyzed by chromatographic spectrophotometric techniques. antioxidant potential was evaluated using several methods: CUPRAC (cupric ion reducing capacity), FRAP (ferric ability plasma), inhibition lipid peroxidation catalyzed cytochrome c, superoxide (SO) scavenging assays. antimicrobial activity oregano means agar-well diffusion assay. hepatoprotective...
The leaves and flowering stem of Origanum vulgare contain essential oils, flavonoids, phenolic acids anthocyanins. We propose a new, simple, one-pot, O. extract (OVE) mediated green synthesis method biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial plasmonic properties.Different concentrations OVEs were used to reduce ions synthetize spherical AuNPs. Their morphology physical properties have been investigated by means transmission electron microscopy,...
Rosmarinus officinalis L. is a widely known species for its medicinal uses, that also used as raw material the food and cosmetic industry. The aim of present study was to offer novel perspective on product originating from this test hepatoprotective activity. tested sample consisted in tincture obtained fresh young shoots. Compounds are evaluated activity polyphenols terpenoids, identified quantified by HPLC-UV-MS GC-MS. Antioxidant assessed vitro, using DPPH, FRAP SO assays....
Public awareness and discussion about animal experiments replacement methods has greatly increased in recent years. The term 'the Three Rs', which stands for the Replacement, Reduction Refinement of experiments, is inseparably linked this context. A common goal within Rs scientific community to develop predictive non-animal models better integrate all available data from vitro, silico omics technologies into regulatory decision-making processes regarding, example, toxicity chemicals, drugs...
The discovery of a new non-toxic metal complex with biological activity represents very active area research. Two Cu
In the present study, scaffold composites based on alginate-pullulan-bioactive glass‑gold nanoparticles were orthotopically implanted in an experimental model of delayed bone union, rats, given by a metabolic pathology, namely osteoporosis. Differences between treated and untreated groups observed efficacy our biomaterial was evaluated applying micro-CT imaging, together with histological evaluation osteoporotic animals sub-critical defects, at 30 60 days. Osteoporosis successfully induced...
The most important concept behind using bone scaffolds is the biocompatibility of material to avoid a local inflammatory response and must have following properties: osteoinduction, osteoconductivity, angiogenesis, mechanical support for cell growth. Gold nanoparticles/gold silver nanoparticles -containing bioactive glasses in biopolymer composites been used enhance regeneration. These were testedin vitroon fibroblast osteoblast lines MTT tests, immunofluorescence, scanning electron...
The main objective of this research is to demonstrate the biocompatibility two experimental graphene dental materials by in vitro and vivo tests for applications dentistry. novel materials, including one restorative composite cement, were subjected cytotoxicity implantation using a rat model non-critical mandibular defect. In induced on human follicle stem cells (restorative composite) dysplastic oral keratinocytes (dental cement) was investigated at 37 °C 24 h. After implantation, 7 weeks,...
Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causing agitation, confusion, rhinitis can produce hyperactivity syndrome in children when combined with benzoates. Additionally, it trigger oxidative stress which consequently generates metabolic disorders. Therefore, the study was designed evaluate harmful effects of additive tartrazine observe beneficial properties blackthorn fruits (Prunus spinosa) on blood organs albino Wistar rats.This carried...
Abstract In the present study, scaffolds based on alginate‐pullulan‐bioactive glass‐ceramic with 0.5 and 1.5 mol % copper oxide were orthotopically implanted in experimental rat models to assess their ability heal an induced bone defect. By implying magnetic resonance imaging scans together histological evaluation of processed samples, a progressive healing was observed within 5 weeks. Furthermore, as regenerative process continued, new tissue formed, enhancing growth irregular spicules...
Nowadays, the discovery of a new non-toxic metal complex with biological activity represents very active area research. Two Cu+2 complexes, [Cu(L1)2(H2O)3] (C1) (HL1= N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)-naphtalenesulfonamide) and [Cu(L2)2(py)2(H2O)] (C2) (HL2= N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-naphtalenesulfonamide), two ligands were synthesized. The X-ray crystal structures complexes determined. In both is five-coordinated, forming CuN2O3 CuN4O chromophore, respectively. act...
Anxiety disorders can associate with oxidative stress and immune system alterations. Our study aimed to chemically analyze Hypericum maculatum (HM) perforatum (HP) dry extracts evaluate their effects along quercetin (Q), on brain biomarkers: malondialdehyde (MDA), catalase (CAT) superoxide dismutase (SOD), inflammatory cytokines: interleukin-1α, (IL-1α), IL-1β, regulated activation normal T cell expressed secreted (RANTES), interferon (IFN), monocyte chemoattractant protein-1 (MCP1),...
Fifteen cases of canine gastric polyps, collected over a 4-year period, were investigated using gross inspection, histological procedures and immunohistochemical techniques for Helicobacter infection. No breed or sex predisposition was found although they occurred mainly in elderly animals. There 9 pedunculated 6 sessile polypoid growths, between 5 to 30 mm diameter developed the pyloric region stomach. The most common type polyps hyperplastic one. inflammatory identified three cases. Foci...
The allicin pleiotropic effects, which include anti-inflammatory, anti-oxidant, anti-tumoral, and antibacterial actions, were well demonstrated correlated with various molecular pathways. immunostimulatory mechanism of has not been elucidated; however, there is a possible cytokine stimulation from immunoglobulin release caused by allicin. In this study, when Wistar female rats CD19+ lymphocytes treated three different doses allicin, immunoglobulins, glutathione, oxidative stress markers...
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared terms the negative effects displayed upon injection Wistar rats. At concentrations tested, antioxidant strategies based on albumin as well rubrerythrin appear to offer observable advantages.
In this work is presented the synthesis of inclusion complexes amygdalin with β-cyclodextrin by three methods: kneading, co-precipitation and freeze drying their characterization. The compounds were synthesized using a molar ratio amygdalin: 1:1. Synthesized analyzed FTIR spectroscopy, X-rays, thermal analysis results confirm formation β-cyclodextrin. studies carried out have shown protective effect amygdalin-β-cyclodextrin obtained drying, kneading coprecipitation against free radicals...
Abstract Background Natural extracts with beneficial biological activities are nowadays of high interest, in various treatment or prophylaxis. Hypericum capitatum has been known for its curative effects centuries and have become interest due to their distinct activity among other Hypericaceae members. In this study, further light is aimed be shed on the secondary-metabolites composition H. extracts, using chromatographic techniques Electron paramagnetic resonance profiles alkaline medium....