A5028351051- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- COVID-19 Clinical Research Studies
- Advanced Drug Delivery Systems
- Long-Term Effects of COVID-19
- Essential Oils and Antimicrobial Activity
- Human Health and Disease
- Nanocomposite Films for Food Packaging
- Herbal Medicine Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Microencapsulation and Drying Processes
- Microbial Metabolites in Food Biotechnology
- Vitamin C and Antioxidants Research
- Therapeutic Uses of Natural Elements
- Drug Solubulity and Delivery Systems
- Bone Metabolism and Diseases
- Phytochemical compounds biological activities
- Mitochondrial Function and Pathology
- Toxin Mechanisms and Immunotoxins
- Advancements in Transdermal Drug Delivery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nanoparticle-Based Drug Delivery
- Pregnancy and preeclampsia studies
University of Oradea
2010-2025
The aim of this paper was to formulate microspheres based on biodegradable polymers (chitosan and sodium alginate), using the complex coacervation technique. Subsequently, prepared were loaded with quercetin (QUE), a pharmacological active ingredient insoluble in water unstable light, temperature air. After preparation, underwent several studies for physical chemical characterization (performed by scanning electron microscopy-SEM, laser 3D scanning, thermal analysis-TA). Furthermore, they...
(1) Background: Oxidative stress markers in the follicular fluid and serum of patient with IVF results (number fertilized oocytes, number embryos, cumulative pregnancy rate) are important establishing causes infertility. (2) Methods: 42 patients were enrolled study over duration 24 months divided into two groups: group female etiology for infertility as a tubal factor, diminished ovarian reserve, endometriosis, unexplained infertility, control consisting male excluding sperm donors no factor...
The incidence and prevalence of cardiovascular diseases are still rising. principal mechanism that drives them is atherosclerosis, an affection given by dyslipidemia a pro-inflammatory state. Paraoxonase enzymes have protective role due to their ability contribute antioxidant anti-inflammatory pathways, especially paraoxonase 1 (PON1). PON1 binds with HDL (high-density lipoprotein), high serum levels lead state against dyslipidemia, diseases, diabetes, stroke, nonalcoholic fatty liver...
Active screening for resistant multidrug strain carriers remains an important component of infection control policy in any healthcare setting indifferent financial and logistical costs. The objective our study was to determine the spectrum bacterial colonization individually among intensive care unit patients. A retrospective observational performed Intensive Care Unit Emergency Clinical County Hospital Oradea during 2017. Medical records patients were used evaluation source ICU admission,...
Liposomes continue to attract great interest due their increased bioavailability in the body and because substances encapsulated are protected while maintaining effectiveness. The aim of this study is obtain “giant” liposomes by lipid film hydration using a preparation formula with two different phospholipids, phosphatidylcholine (PC) phosphatidylserine (PS). Firstly, macro- microscopic characterization, total phenols content antioxidant capacity plant Stellaria media (L.) Vill. were...
Caffeic acid (CA), a phenolic acid, is powerful antioxidant with proven effectiveness. CA instability gives it limited use, so encapsulation in polymeric nanomaterials has been used to solve the problem but also obtain topical hydrogel formulas. Two different formulas of caffeic liposomes were incorporated into three carbopol-based hydrogels. A Franz diffusion cell system was evaluate release from For viscoelastic measurements hydrogels, equilibrium flow test used. The dynamic tests examined...
The presence of vitamin D3 deficiency associated with the metabolic syndrome (MS) has important public health effects. This study aims to investigate relationship between deficiency, MS and receptor (VDR), GC Vitamin D binding protein (GC), cytochrome P450 family 2 subfamily R member 1 (CYP2R1) gene polymorphisms, genes whose encoded proteins are responsible for metabolism transport. A total 58 participants were included in this (age 39 ± 12 years) selected over a 12-month period. They...
Background . The antimicrobial activity of the Equisetum arvense L. extract and mechanisms involved in vitro effects on endothelial vascular cells exposed to hyperosmotic stress were evaluated. Methods Antimicrobial was evaluated by disk diffusion method minimum inhibitory concentration (MIC) determination, oxidative stress, inflammation, apoptosis, pretreatment with L., caffeic acid, cathechin, quantified. Results results have shown that exhibited antibacterial only pathogenic gram‐positive...
We aimed to assess the current state of PKU screening and management in region southeastern Europe.A survey was performed involving all identified professionals responsible for 11 countries from South-Eastern Europe (Albania, Bulgaria, Bosnia Herzegovina, Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, Slovenia). The questionnaire designed characteristics regarding three main areas: nation-wide characteristics, screening, responding centre. It consisted 56 questions....
BACKGROUND: Equisetum arvense L., commonly known as field horsetail is a perennial fern of which extracts are rich sources phenolic compounds, flavonoids, and acids. Activation SIRT1 that was shown to be involved in well-known signal pathways diabetic cardiomyopathy has protective effect against oxidative stress, inflammatory processes, apoptosis the basis diseases such obesity, diabetes mellitus, or cardiovascular diseases. The aim our study evaluate antidiabetic cardioprotective effects...
Background and Objectives: Fibromyalgia (FM), through the presence of widespread chronic pain, stiffens musculoskeletal system causes sleep disturbances fatigue. Through this study, we aimed to compare effectiveness two different recovery interventions for improving quality: a standard, multidisciplinary intervention in hospital versus therapy focused on intrinsic relaxation at home. Materials Methods: This study included 60 adult patients who participated voluntarily were diagnosed with FM...
Fibromyalgia (FM), through the presence of clinical polymorphism and widespread chronic pain, stiffens musculoskeletal system in specific locations. For patients with FM, this comparative study was conducted to understand benefits conservative therapy versus intrinsic relaxation help clinicians select most appropriate interventions for condition. 60 FM from two cohorts (Group A Group B) were included analysis. received physical therapy, group B recovery relaxation. Their assessment using...
Topical anti-inflammatory and analgesic effect for the treatment of rheumatoid arthritis is major interest because their fewer side effects compared to oral therapy. The purpose this study was prepare different types topical formulations (ointments gels) containing synthetic natural agents with excipients (e.g.,: surfactants, gel-forming) arthritis. combination Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), diclofenac sodium, a agent methyl salicylate, lyophilized extract Calendula...
(1) Background: Semen analysis is a poor predictor of the fertilization potential spermatozoa and male factor may contribute to outcomes IVF procedure, despite normal semen analysis. The microfluidic sperm selection (ZyMot-ICSI) based on with lowest DNA fragmentation rate, but studies do not prove better clinical after this method. (2) Methods: We conducted retrospective trial comparing 119 couples that were allocated classic gradient centrifugation method (control group), 120 technique...
The aim of this study was to determine the potential pharmaceutical applications quercetin—a natural flavonoid compound with a polyphenolic structure—following its encapsulation in polymeric microspheres resistant degradation. were prepared from compounds (chitosan and sodium alginate) via complex coacervation method, goal protecting quercetin degradation reactions that can affect bioactivity. After prepared, they characterized using various analytical methods. efficiency (EE (%)), swelling...
To find new natural remedies in diabetes, this study investigated the biological activity of two extracts obtained from fruits (PhyF) and herba (PhyH) Physalis alkekengi var. franchetii L. on human umbilical vein endothelial cells (HUVECs) exposed to normo- hyperglycemic conditions. The effect was quantified by malondialdehyde, IL-31 IL-33 levels correlation with physico-chemical characterization antioxidant activity. Additionally, PhyP extract, caspase-3, IL-6, IL-10, tumor necrosis factor...
The therapeutic benefits of medicinal plants are well known and have been collected as important data on ethnomedicine [...]
The aim of this study was to evaluate the phytochemical profile and antioxidant properties extracts from three Rosa species (R. canina, R. damascena, cairo), develop investigate topical formulations with lyophilized forms for treatment psoriasis. Phytochemical screening in vitro total capacity (DPPH, FRAP, CUPRAC, SOD) studied samples were examined compared. Lyophilized roses dissolved Transcutol HP different creams prepared. Franz diffusion method used drug release biocompatibility tested...
This study aimed to evaluate the comparative biological effects of Polygonum aviculare L. herba (PAH) extract and quercetin-entrapped liposomes on doxorubicin (Doxo)-induced toxicity in HUVECs. HUVECs were treated with two formulations loaded PAH (L5 L6) quercetin (L3 prepared phosphatidylcholine L4 phosphatidylserine). The results obtained atomic force microscopy, zeta potential entrapment liposome efficiency confirmed interactions or free a controlled release flavonoids entrapped all...