A5010794754- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Animal testing and alternatives
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Environmental Toxicology and Ecotoxicology
- T-cell and B-cell Immunology
- Gene Regulatory Network Analysis
- Immune Cell Function and Interaction
- Streptococcal Infections and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Chromatin Dynamics
- Bacteriophages and microbial interactions
- Immunodeficiency and Autoimmune Disorders
- Protein Structure and Dynamics
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Biomedical Text Mining and Ontologies
- Cell Image Analysis Techniques
Humboldt-Universität zu Berlin
2022-2024
Charité - Universitätsmedizin Berlin
2022-2024
Freie Universität Berlin
2022-2024
Volkswagen Foundation
2024
Technische Universität Braunschweig
2007-2014
Helmholtz Centre for Infection Research
2004-2011
Czech Academy of Sciences, Institute of Microbiology
2008
The database VBASE2 provides germ-line sequences of human and mouse immunoglobulin variable (V) genes. It acts as an interconnecting platform between several existing self-contained data systems: integrates genome sequence links to the V genes in Ensembl Genome Browser. For a single gene sequence, all references EMBL nucleotide are provided, including for V(D)J rearrangements. Furthermore, cross-references VBASE database, IMGT Kabat available. A DAS server allows display within can be...
PRODORIC is a database that provides annotated information on the regulation of gene expression in prokaryotes.It integrates large compilation regulatory data including transcription factor binding sites, promoter structures and patterns.The whole dataset manually curated relies published results extracted from scientific literature.The current extended version contains for several new microorganisms.Major improvements were realized design web interface accessibility stored information.The...
Public awareness and discussion about animal experiments replacement methods has greatly increased in recent years. The term 'the Three Rs', which stands for the Replacement, Reduction Refinement of experiments, is inseparably linked this context. A common goal within Rs scientific community to develop predictive non-animal models better integrate all available data from vitro, silico omics technologies into regulatory decision-making processes regarding, example, toxicity chemicals, drugs...
To provide an integrated bioinformatics platform for a systems biology approach to the of pseudomonads in infection and biotechnology database SYSTOMONAS (SYSTems pseudOMONAS) was established. Besides our own experimental metabolome, proteome transcriptome data, various additional predictions cellular processes, such as gene-regulatory networks were stored. Reconstruction metabolic achieved via comparative genomics. Broad data integration is realized using SOAP interfaces well established...
Abstract Although the entire mouse genome has been sequenced, there remain challenges concerning elucidation of particular complex and polymorphic genomic loci. In murine Igh locus, different haplotypes exist in inbred strains. For example, Ighb haplotype sequence Mouse Genome Project strain C57BL/6 differs considerably from Igha BALB/c, which widely used analyses Ab responses. We have sequenced annotated 3′ half locus 129S1/SvImJ, covering CH region approximately VH region. This comprises...
ProdoNet is a web-based application for the mapping of prokaryotic genes and corresponding proteins to common gene regulatory metabolic networks. For given list genes, system detects shared operons, identifies co-expressed deduces joint regulators. In addition, contribution pathways becomes visible on KEGG maps. Furthermore, co-occurrence interest in expression profiles can be added visualization global network. this way, provides basis functional genomics approaches interpretation...
Abstract Summary: GeneReporter is a web tool that reports functional information and relevant literature on protein-coding sequence of interest. Its purpose to support both manual genome annotation document retrieval. PubMed references corresponding are detected by the extraction query words from UniProt entries homologous sequences. Data protein families, domains, potential cofactors, structure, function, cellular localization, metabolic contribution DNA binding sites complement given gene...
Streptococci are the causative agent of many human infectious diseases including bacterial pneumonia and meningitis. Here, we present Strepto-DB, a database for comparative genome analysis group A (GAS) B (GBS) streptococci. The known genomes various GAS GBS contain large fraction distributed genes that were found absent in other strains or serotypes same species. Strepto-DB identifies homologous proteins deduced from interest. It allows elucidation core- pan-genomes via genome-wide...
Antibodies play a central role in the adaptive immunedefense of all vertebrates. Thereby, specific recognitionof antigen structures by antibody molecules determinesthe success immune response. Therefore, reper-toire binding sites within systemof an individuum, but also, population, has beena mean focus immunological research last 3decades. The first tool to analyse DNA sequence theantigen site was DNAPLOT http://www.dnaplot.de. Associated with Vbase database[1],the search page its kind...