Dragoș Apostu

ORCID: 0000-0001-9046-9432
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About
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Research Areas
  • Total Knee Arthroplasty Outcomes
  • Orthopaedic implants and arthroplasty
  • Orthopedic Infections and Treatments
  • Knee injuries and reconstruction techniques
  • Thyroid Cancer Diagnosis and Treatment
  • Periodontal Regeneration and Treatments
  • Cancer Diagnosis and Treatment
  • Bone health and osteoporosis research
  • Osteoarthritis Treatment and Mechanisms
  • Foot and Ankle Surgery
  • Oral microbiology and periodontitis research
  • Bone Tissue Engineering Materials
  • Tendon Structure and Treatment
  • Hip and Femur Fractures
  • Blood transfusion and management
  • Dental Implant Techniques and Outcomes
  • Bone health and treatments
  • Thyroid and Parathyroid Surgery
  • BRCA gene mutations in cancer
  • Sarcoma Diagnosis and Treatment
  • Bone Tumor Diagnosis and Treatments
  • Musculoskeletal synovial abnormalities and treatments
  • Oral health in cancer treatment
  • Cannabis and Cannabinoid Research
  • HIV/AIDS oral health manifestations

Iuliu Hațieganu University of Medicine and Pharmacy
2016-2024

University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2022-2024

Spitalul Clinic de Psihiatrie Alexandru Obregia
2018

Bone consolidation after severe trauma is the most challenging task in orthopedic surgery. This study aimed to develop biomimetic composite for coating Ti implants. Afterwards, these implants were tested vivo assess bone absence or presence of high-frequency pulsed electromagnetic short-waves (HF-PESW).Biomimetic was successfully developed using multi-substituted hydroxyapatite (ms-HAP) functionalized with collagen (ms-HAP/COL), embedded into poly-lactic acid (PLA) matrix (ms-HAP/COL@PLA),...

10.2147/ijn.s205880 article EN cc-by-nc International Journal of Nanomedicine 2019-07-01

The SARS-Cov-2 virus caused a high morbidity and mortality rate disease, that is the COVID-19 pandemic. Despite unprecedented research interest in this field, lack of specific treatments leads to severe complications number cases. Current treatment includes antivirals, corticosteroids, immunoglobulins, antimalarials, interleukin-6 inhibitors, anti-GM-CSF, convalescent plasma, immunotherapy, antibiotics, circulation support, oxygen therapy, support. Due limited results, until are available,...

10.1080/03602532.2021.1895204 article EN Drug Metabolism Reviews 2021-03-08

Despite the great success of primary total hip arthroplasty (THA), number revisions has significantly increased over past years. The objectives study were to investigate main causes that lead revision THA, time interval between THA and revision, results surgery. We also assessed whether there was any correlation patients' age, BMI, diagnosis for cause failure.This paper retrospectively analyzed 189 patients with surgery performed a six-year period, 2015 2020. Patients' charts reviewed...

10.15386/mpr-2136 article EN Medicine and Pharmacy Reports 2022-04-20

The aim was to assess the effects of periodontal disease in promoting liver fibrosis a rat model ligature-induced periodontitis.Twenty-four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), 14 (PER14), 21 (PER21). Experimental induced by placement silk ligature around mandibular incisors. following parameters assessed: gingival index, tooth mobility; status, and portal vein caliber ultrasound examination; bone retraction, mineral...

10.1002/jper.18-0585 article EN Journal of Periodontology 2019-01-28

The objective of the study was to evaluate and compare effect different drugs such as simvastatin, alendronate, tibolone for titanium implant osseointegration enhancement.Eighty female albino Wistar rats were equally divided into five groups: Group I (ovariectomy), II (sham ovariectomy), III (alendronate + IV (simvastatin V (tibolone ovariectomy). Three months after ovariectomy, we performed bilateral intramedullary nailing in all groups, followed by oral administration or 12 weeks....

10.1111/clr.13602 article EN Clinical Oral Implants Research 2020-04-12

Giant-cell tumours are benign aggressive bone lesions that can affect any part of the skeleton. In early stages, curettage is preferred, but in case local recurrence or voluminous periacetabular region, wide resection and reconstruction recommended. The purpose this article to increase clinicians' awareness importance follow-up these patients describe a giant-cell tumour pelvis. We present 25-year-old female who underwent internal hemipelvectomy assisted by 3D cutting-guides with custom-made...

10.3390/diagnostics13030485 article EN cc-by Diagnostics 2023-01-29

Follicular thyroid carcinomas (FTC) represent 6-10 % of all carcinomas; the evolution FTC is quite controversial, partly due to frequent changes histopathological definition (minimally invasive-MIFTC or widely invasive carcinoma-WIFTC) and treatment strategies adjustments.This research aims examine diagnostic procedure, therapeutic attitude survival rates patients with FTC, over a period 16 years in same institution, follow-up at least 4 years, by analyzing correlations between histology...

10.4183/aeb.2020.170 article EN Acta Endocrinologica (Bucharest) 2020-01-01

The aim of this research was to validate the use a gentamicin (GEN) and nano-hydroxiapatite (nHAP)-loaded polycaprolactone nanostructured membrane (NM) as an innovative, highly efficient, low-cost treatment for periodontitis. We conducted in vivo study on Wistar rats, which we induced periodontitis by placing silk ligatures around first right left upper molars. subjects were divided into three groups; group received no periodontal treatment, second open flap debridement, third together with...

10.3390/membranes14030060 article EN cc-by Membranes 2024-02-26

In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers enhance bone mineralization. The main aim this study was to investigate in vivo effects HF-PEMFs on fracture healing using a rat model. A femur established by surgery 20 male Wistar rats. Titanium nails were implanted reduce stabilize fracture. After surgery, rats equally divided into untreated control treated group (from first...

10.17305/bjbms.2019.3854 article EN Bosnian Journal of Basic Medical Sciences 2019-02-20

Absorbable atelo-collagen type 1 represents a new approach for guided bone regeneration with several reported advantages such as: osteoblast attachment, proliferation, mineralization potential, absorption of growth factors and inhibition bacterial pathogen colonization. The aim this study was to assess the clinical, radiological (preoperative width, re-entry gain), Periotest measurements histologic benefits atelo-collagen-derived bovine grafts (ImploBone) in combination an I barrier membrane...

10.14670/hh-18-108 article EN PubMed 2019-09-01
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