A5067669463- Advanced Drug Delivery Systems
- Bone Tissue Engineering Materials
- Bacterial biofilms and quorum sensing
- Hydrogels: synthesis, properties, applications
- Microfluidic and Bio-sensing Technologies
- Seaweed-derived Bioactive Compounds
- Polymer Surface Interaction Studies
- Synthesis and biological activity
- Vagus Nerve Stimulation Research
- Quinazolinone synthesis and applications
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Curcumin's Biomedical Applications
- Conducting polymers and applications
- Antimicrobial agents and applications
- Microfluidic and Capillary Electrophoresis Applications
- Vestibular and auditory disorders
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Composting and Vermicomposting Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inorganic Fluorides and Related Compounds
- Bacterial Identification and Susceptibility Testing
- Advanced materials and composites
- Nanoparticle-Based Drug Delivery
Technical University of Cluj-Napoca
2011-2024
Babeș-Bolyai University
1999-2009
Academy of Agricultural and Forestry Sciences
1999
The aim of the paper is to obtain and characterize k-carrageenan–chitosan dual hydrogel multilayers shell BSA gel microcapsules, as a carrier for curcumin, possible antitumoral agent in biological studies. We used CaCO 3 template synthesize non-toxic /BSA particles microtemplates by coprecipitating CaCl 2 solution that contains dissolved BSA, with an equimolar Na CO solution. microcapsules assembled through layer-by-layer deposition technique calcium cross-linked k-carrageenan alternating...
Abstract The development of systems for targeted delivery Sorafenib in unresectable hepatocellular carcinoma to reduce the systemic toxicity is a challenge. In our article, we successfully prepared core‐shell microcapsules based on bovine serum albumin gel with polyelectrolyte complex multilayer shell polysaccharides opposite charges, hyaluronic acid, and chitosan, encapsulating Sorafenib, as targeting system improved therapy. A core was formed by method sacrificial CaCO 3 template, followed...
The aim of this paper is obtaining and characterizing hydrogels based on different ratios oxidized alginate (oA) k-carrageenan (C), chemically cross-linked with adipic dihydrazide (adh). (A) was first sodium metaperiodate in order to transform it into the dialdehyde derivative, a more reactive compound than alginate. A known procedure for oxidation ethanol-water improve reactivity by transforming hydroxyl end-groups used, preceded partially cleavage chains. In second stage, mixture...
Background: Bacterial biofilm formation (BBF) proves itself to be in the spotlight of microbiology research due wide variety infections that it can associated with, involvement food spoilage, industrial biofouling and perhaps sewage treatment. However, BBF remains difficult study lack standardization existing methods expensive equipment needed. We aim describe a new inexpensive easy reproduce protocol for 3D-printed microfluidic device used dynamic manner. Methods: SolidWorks 3D CAD Software...
A realistic modelling of the way biofilms form and evolve in time requests a dynamic approach. In this study, proposed route uses continuous-flow bioreactors under controlled flow rates temperature culture medium containing bacteria or fungi. 3D printed, Polylactic acid (PLA), flow-based with integrated copper electrodes were used to investigate effect dielectrophoresis on formation growth Staphylococcus aureus ATCC 25923, Enterococcus faecalis 29212, Pseudomonas aeruginosa 27853, Klebsiella...
Dexamethasone is one of the most often used corticosteroid drugs for sensorineural hearing loss treatment, and either by intratympanic injection or through systemic delivery. In this study, a biopolymer lipid hybrid microcarrier was investigated enhanced local drug delivery sustained release at round window membrane level middle ear treatment (SNHL). Dexamethasone-loaded dexamethasone-free microparticles were prepared using biopolymers (polysaccharide protein, pectin bovine serum albumin,...
Understanding the effect of different electric potentials upon preferential formation biofilms inside microfluidic devices could represent a step forward in comprehending mechanisms that govern biofilm and growth. 3D printed were used to investigate influence dielectrophoretic forces on growth Staphylococcus aureus ATCC 25923 biofilms. Bacterial suspensions 2.5 McF pushed through channels while simultaneously applying various potential differences between 10 60 V. The overall field...
In the present study, Zn-hydroxyapatite (Zn-HA) was synthesized, powder thermally treated at different temperatures and then characterized. The Zn-HA characterized mainly by FTIR XRD, but have been performed investigations like SEM, BET size distribution. addition of ZnO in hydroxyapatite causes alleged interactions with existing groups HA, which amend corresponding signals to these IR spectra. X-ray diffractograms for samples (untreated heat-treated) recorded microstructural parameters all...
A functional hydrogel containing biopolymer microcarriers loaded with dexamethasone was developed to address the hearing loss that results from cisplatin ototoxicity. The drug delivery platform tested both in vitro HEI-OC1 inner ear cell line and vivo a rat animal model. newly described formula offered prolonged release of contained for up six days transformed into solid state at body temperature, thus counteracting its clearing through Eustachian tube when injected middle ear. When vitro,...
The paper presents methodologies for the determinat ion of corn starch packaging ultimate biodegradability under controlle d composting conditions by measurement amount carbon dioxide evolved and degree disintegration at end test. composti ng takes place in an installation with controlled temperature, aeration humidity.
The aim of this study is to develop core shell microcapsules bovine serum albumin (BSA) gel with a complex polyelectrolite multilayer natural polysaccharides opposite charges, pectin (P), chitosan (Chi), and hyaluronic acid (HA) respectively, encapsulating Doxorubicin (Dox) as carrier for targeted anti-tumoral treatment hepatic cell carcinoma (HCC). A sacrificial CaCO3 template method was used in order obtain BSA layer-by-layer (Lbl) deposition technique complexes formed between P/Chi the...
This work proposes a novel complex multi-layered material consisting of porous titanium as substrate and coating chitosan film engulfing microsphere loaded with growth factors such BMP2 (bone morphogenic protein 2) IGF1 (insulin-like factor-1). The microspheres were obtained through deposition dual layers calcium cross linked pectin–chitosan/pectin polyelectrolyte onto BSA (bovine serum albumin) gel core. multilayer was conceived to behave like 3rd generation biomaterial, by slow delivery...
The influence of solution/free volume ratio on the specific surface area and pore MOF-5 was investigated. synthesized, by solvothermal reaction, using an identical starting mixture, at different 0.245, 0.807 3.429. decreased from 3018 m2/g to 2680 1099 respectively. nitrogen adsorption capacity decrease in same manner 817.35 cm3/g 740.75 294.56
Study on the effect of in Situ Surface treatmentS medical microfluidic SyStemS obtained through additive manufacturingThis paper presents a comparative study effects in-situ surface modifications performed "H" type systems via manufacturing.The microsystem was printed using polylactic acid filament an Ender-5 pro printer.The modification main channel done chloroform by two different methods: vapor smoothing and flushing.The roughness studied optical microscope imageJ software, as well...
We confirmed, on the basis of chemical and physicochemical (melting points, IR- 1H-NMR-spectra) data, that products isolated by monoacylation cyclic maleic- phthalic-hydrazides have only O-acyl derivatives nature although owing to tautomerism. These hydrazides may give rise N- or/and in such reactions. Simultaneously, we showed claims for obtainment N-acyl were not valid. Also reacting maleic-, respectively phthalic-hydrazide, with 4-chlorobenzoylchloride two new O-monoacylderivatives [3-(...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”